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Brain Gangliosides in Development

  • Chapter
Chemistry and Brain Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 13))

Abstract

Gangliosides are glycosphingolipids containing sialic acid (primarily N-acetyl-neuraminic acid). They are present in brain in different forms, which differ in the pattern of fatty acids and sphingosines, and in the number and sequence of units forming the carbohydrate portion of the molecule. The main series of known gangliosides are distinguished on the basis of the common neutral glycosphingolipid moiety (*): a) G 3 series, galac-tosyl-β(1–4)glucosyl-β(1–1)ceramide; b) G 2 series, N-acetyl-galactosaminyl-β(1–4)galactosyl-β(1–4)glucosyl-β(1–1)ceramide; c) G 1 series, galactosyl-β(1–3)N-acetyl-galactosaminyl-β(1–4)galactosyl-β(1–4)glucosyl-β(1–1)c e-ramide. The G 3 and G 2 series contain gangliosides having one (GM3 and GM2) or two (GD3 and GD2) residues of sialic acid; the G 1 series contains gangliosides having one (GM1), two (GD1a and GD1b), three (GT1a and GT1b), and four (GQ1) residues of sialic acid.

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Authors and Affiliations

  1. Department of Biological Chemistry, Medical School, Milan, Italy

    G. Tettamanti

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  1. G. Tettamanti
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Editors and Affiliations

  1. Institute of Pharmacology and Pharmacognosy, University of Milan, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

  2. Department of Biochemistry, Charing Cross Hospital Medical School, University of London, UK

    Alan N. Davison (Professor of Biochemistry) (Professor of Biochemistry)

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© 1971 Plenum Press, New York

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Tettamanti, G. (1971). Brain Gangliosides in Development. In: Paoletti, R., Davison, A.N. (eds) Chemistry and Brain Development. Advances in Experimental Medicine and Biology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7236-3_7

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  • DOI: https://doi.org/10.1007/978-1-4684-7236-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7238-7

  • Online ISBN: 978-1-4684-7236-3

  • eBook Packages: Springer Book Archive

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