Phospholipid Metabolism in the Developing Brain
The adult mammalian brain contains more phospholipid per unit wet weight than any other tissue and it is distributed among the sub-cellular components. During the course of development the phospholipids are deposited not only as a result of the increase in brain size but also as a result of the structural changes during maturation, notably the deposition of myelin. The rate of deposition in the brain as a whole is well documented especially for the rat and human and the literature up to 1964 has been summarised by Ansell and Hawthorne (1). A more recent comprehensive study of the rat brain has been made by Wells and Dittmer (2). During development the fatty acid composition of some phospholipids changes (e.g. ref. 3) which may be due to preferential synthesis or loss of certain phospholipids or exchange of fatty acids within the molecules themselves.
KeywordsPhospholipid Metabolism Glycerol Kinase Label Precursor Brain Phospholipid Adult Mammalian Brain
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