Brain and Myelin Sterols Studied Using Specific Inhibitors of Sterol Synthesis

  • R. Fumagalli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 13)


Sterols are major components of brain cellular and subcellular membranes and they are represented almost exclusively in mature mammalian brain by non-esterified cholesterol. However, during brain maturation and myelin deposition, stages of development characterized by a high rate of cholesterol biosynthesis, considerable amounts of desmosterol, a sterol precursor of cholesterol, are present in the brain of several mammalian species, i ncIudi ng man (1).


Cholesterol Biosynthesis Total Sterol Sterol Synthesis Cholesterol Precursor Spinal Cord Homogenate 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • R. Fumagalli
    • 1
  1. 1.Institute of PharmacologyUniversity of MilanMilanItaly

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