Brain and Myelin Sterols Studied Using Specific Inhibitors of Sterol Synthesis
Sterols are major components of brain cellular and subcellular membranes and they are represented almost exclusively in mature mammalian brain by non-esterified cholesterol. However, during brain maturation and myelin deposition, stages of development characterized by a high rate of cholesterol biosynthesis, considerable amounts of desmosterol, a sterol precursor of cholesterol, are present in the brain of several mammalian species, i ncIudi ng man (1).
KeywordsCholesterol Biosynthesis Total Sterol Sterol Synthesis Cholesterol Precursor Spinal Cord Homogenate
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