Biosynthesis of Sterols in Developing Brain

  • E. Grossi Paoletti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 13)


During development brain tissue actively synthesizes cholesterol to meet the requirements necessary for formation of its structures (1, 2). The biosynthetic activity in brain varies from species to species, according to the sequence of the developmental stages and is higher during the period of maximal brain growth (3). In adults, however, cholesterol biosynthesis is hardly detectable in brain (2). Very little is known about the mechanisms and control of cholesterol synthesis in brain, although synthesis in liver has been studied extensively (4).


Cholesterol Synthesis Brain Homogenate Cholesterol Biosynthesis Mevalonic Acid Sterol Synthesis 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • E. Grossi Paoletti
    • 1
  1. 1.Institute of PharmacologyUniversity of MilanMilanItaly

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