Biosynthesis of Sterols in Developing Brain
During development brain tissue actively synthesizes cholesterol to meet the requirements necessary for formation of its structures (1, 2). The biosynthetic activity in brain varies from species to species, according to the sequence of the developmental stages and is higher during the period of maximal brain growth (3). In adults, however, cholesterol biosynthesis is hardly detectable in brain (2). Very little is known about the mechanisms and control of cholesterol synthesis in brain, although synthesis in liver has been studied extensively (4).
KeywordsCholesterol Synthesis Brain Homogenate Cholesterol Biosynthesis Mevalonic Acid Sterol Synthesis
Unable to display preview. Download preview PDF.
- 1.Srere, P.A., Chaikoff, J.L., Treitmann, S., and Burstein, L.S. J. Biol. Chem. 182:629 (1950)Google Scholar
- 3.Korey, S.R., Stein, A. in Regional Neurochemistry (Eds. S.S. Kety and J. Elkes), C.C. Thomas, Springfield (1961)Google Scholar
- 4.Olson, J.A. Erg. Physiol. Biol. Chemie und Exp. Pharmakol. 56:163 (1965)Google Scholar
- 7.Davison, A.N. in Adv. Lipid Research vol. 3 (Eds. D. Kritchevsky and R. Paoletti) Academic Press (1965)Google Scholar
- 10.Aeberhard, E., and Menkes, J.H. J. Biol. Chem. 243:3884 (1968)Google Scholar
- 13.Bucher, N.L.R., and McGarrahan, K. J. Biol. Chem. 222:1 (1956)Google Scholar
- 14.Popják, G. in Methods in Enzymology, vol. XV (Ed. R.B. Clayton) Academic Press (1969)Google Scholar
- 16.Galli, G., Weiss, J.F., and Grossi Paoletti, E. Science 162:1495 (1968)Google Scholar
- 17.Fish, W.A., Boyd, J.E., and Stokes, W.M. J. Biol. Chem. 237:334 (1962)Google Scholar