The Blood Brain Barrier

  • Hugh Davson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 13)


The concept of a barrier between blood, on the one hand, and the brain on the other derives from the classical studies of Ehrlich and of Goldmann on vital staining; it was noted that a large variety of acid dyes, of which trypan blue was one, would pass out of the blood into the tissues of the body making them voloured; the brain and spinal cord stood out in contrast to the rest of the tissues in that, with the exception of highly localized regions, such as the area postrema, they remained unstained. In the thirties and forties of this century some doubt was cast on this concept of a barrier between blood and brain; thus King in 1938 (1) argued that the essential phenomenon was one of failure to stain, and this could have been due to the absence of suitable connective tissue to take up the stain.


Cerebrospinal Fluid Trypan Blue Extracellular Fluid Choroid Plexus Area Postrema 
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  1. 1.
    King, L.S. Res. Publ. Ass. nerv. ment. Dis. 18: 150 (1938)Google Scholar
  2. 2.
    Goldmann, E.C. Beitr. klin. Chir. 64:192 (1909)Google Scholar
  3. 3.
    Goldmann, E.C. Abh. preuss. Akad. Wiss., Phys.-Math. Kl. No. 1, I (1913)Google Scholar
  4. 4.
    Stern, L., and Gautier, R. Arch. int. Physiol. 17: 138 (1921)CrossRefGoogle Scholar
  5. 5.
    Stern, L., and Gautier, R. Arch. int. Physiol. 17: 391 (1922)CrossRefGoogle Scholar
  6. 6.
    Stern, L., and Gautier, R. Arch. int. Physiol. 20: 403 (1923)CrossRefGoogle Scholar
  7. 7.
    Davson, H., and Spaziani, E. J. Physiol. 149: 135 (1959)PubMedGoogle Scholar
  8. 8.
    Davson, H., Kleeman, C.R., and Levin, E. J. Physiol. 159:67 (1961)Google Scholar
  9. 9.
    Rall, D.P., Oppelt, W.W., and Patlak, C.S. Life Sci. 2:43 (1962)CrossRefGoogle Scholar
  10. 10.
    Van Harreveld, A., Crowell, J., and Malhotra, S.K. J. Cell Biol. 25: 117 (1965)CrossRefGoogle Scholar
  11. 11.
    Davson, H. J. Physiol. 129: III (1955)Google Scholar
  12. 12.
    Clemente, C.D., and Holst, E.A. Arch. Neurol. Psychiat. 21:66 (1954)Google Scholar
  13. 13.
    Karnovsky, M.J. J. Cell Biol. 35: 213 (1967)PubMedCrossRefGoogle Scholar
  14. 14.
    Reese, T.S., and Karnovsky, M.J. J. Cell Biol. 34: 207 (1967)PubMedCrossRefGoogle Scholar
  15. 15.
    Brightman, M.W., and Reese, T.S. J. Cell Biol. 40: 648 (1969)PubMedCrossRefGoogle Scholar
  16. 16.
    Wallace, G.B., and Brodie, B.B. J. Pharmacol. 65: 220 (1939)Google Scholar
  17. 17.
    Wallace, G.B., and Brodie, B.B. J. Pharmacol. 70: 418 (1940)Google Scholar
  18. 18.
    Davson, H., and Bradbury, M. Symp. Soc. Exp. Biol, 19: 349 (1964)Google Scholar
  19. 19.
    Olsen, N.S., and Rudolph, G.G. Amer. J. Physiol. 183:427 (1955)Google Scholar
  20. 20.
    Davson, H. Physiology of the Ocular and Cerebrospinal Fluids. J. & A. Churchill, London (1956)Google Scholar
  21. 21.
    Bradbury, M., and Davson, H. J. Physiol. 170:195 (1964)PubMedGoogle Scholar
  22. 22.
    Welch, K. Brain Research 16:453 (1969)PubMedCrossRefGoogle Scholar
  23. 23.
    Davson, H. in The Cerebrospinal Fluid. Ciba Foundn. Symp. London: Churchill. (1958)Google Scholar
  24. 24.
    Rougemont, J. et al. J. Neurophysiol. 23:485 (1960)PubMedGoogle Scholar
  25. 25.
    Ames, A. et al. J. Neurophysiol. 27: 672 (1964)PubMedGoogle Scholar
  26. 26.
    Sadler, K., and Welch, K. Nature 215:884 (1967)PubMedCrossRefGoogle Scholar
  27. 27.
    Fencl, V., Miller, T.B., and Pappenheimer, J.R. Amer. J. Physiol. 210:459 (1966)Google Scholar
  28. 28.
    Cohen, M.W., Gerschenfeld, H.M., and Kuffler, S.W. J. Physiol. 192:363 (1968)Google Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Hugh Davson
    • 1
  1. 1.University CollegeLondon, W.C.I.England

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