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Methods for Measuring Indolealkylamine and Catecholamine Turnover Rate “In Vivo”

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Chemistry and Brain Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 13))

Abstract

Many theoretical and practical problems are encountered in designing methods to calculate turnover rates of neuronal catecholamines and serotonin “in vivo.” The great majority of these difficulties derives from our incomplete understanding of the morphology and biochemistry of monoaminergic nerves. Frequently we circumvent the barriers of our ignorance by over simplifications leading to the formulation of kinetic models. Not only are these models unsatisfactory because of the implicit assumptions but as listed in Table 1, other limitations impair the in vivo measurements of turnover rates of brain monoamines in animals. Of course, the difficulties become insurmountable if we try to measure turnover rates of brain monoamines in man.

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Authors and Affiliations

  1. Laboratory of Preclinical Pharmacology, National Inst. of Mental Health, Saint Elizabeths Hospital, Washington, D.C., USA

    E. Costa

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  1. E. Costa
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Editors and Affiliations

  1. Institute of Pharmacology and Pharmacognosy, University of Milan, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

  2. Department of Biochemistry, Charing Cross Hospital Medical School, University of London, UK

    Alan N. Davison (Professor of Biochemistry) (Professor of Biochemistry)

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© 1971 Plenum Press, New York

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Costa, E. (1971). Methods for Measuring Indolealkylamine and Catecholamine Turnover Rate “In Vivo”. In: Paoletti, R., Davison, A.N. (eds) Chemistry and Brain Development. Advances in Experimental Medicine and Biology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7236-3_13

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  • DOI: https://doi.org/10.1007/978-1-4684-7236-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7238-7

  • Online ISBN: 978-1-4684-7236-3

  • eBook Packages: Springer Book Archive

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