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Expression of Recombinant Human FSH, LH, and CG in Mammalian Cells: A Model for Probing Functional Determinants

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Follicle Stimulating Hormone

Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

The family of glycoprotein hormones includes pituitary thyrotropin (TSH), lutropin (LH), and follitropin (FSH) and placental chorionic gonadotropin (CG). TSH is critical for the maintenance of thyroid function; LH and FSH are needed for normal gonadal function, and CG is important for sustaining the corpus luteum during pregnancy. Each hormone is a heterodimer of 2 noncovalently associated subunits, α and β, that are encoded by separate genes located on different chromosomes in humans. The β-subunit confers the unique biological specificity for each hormone. Newly synthesized α -and β-subunits are rapidly assembled in the endoplasmic reticulum, and the oligosaccharides in the dimers undergo hormone-specific posttranslational modifications. Thus, the biological activity of these glycoprotein hormones can be regulated at several steps in the biosynthetic/secretory pathway.

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Authors
  1. I. Boime
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  2. J. Keene
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  3. A. B. Galway
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  4. F. A. M. Fares
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  5. P. LaPolt
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  6. A. J. W. Hsueh
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Editor information

Editors and Affiliations

  1. Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, 60611, Chicago, IL, USA

    Mary Hunzicker-Dunn Ph.D.

  2. Department of Neurobiology and Physiology, Northwestern University, 60201, Evanston, IL, USA

    Neena B. Schwartz Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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Boime, I., Keene, J., Galway, A.B., Fares, F.A.M., LaPolt, P., Hsueh, A.J.W. (1992). Expression of Recombinant Human FSH, LH, and CG in Mammalian Cells: A Model for Probing Functional Determinants. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_9

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  • DOI: https://doi.org/10.1007/978-1-4684-7103-8_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7105-2

  • Online ISBN: 978-1-4684-7103-8

  • eBook Packages: Springer Book Archive

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