Abstract
Intrinsic human follicle stimulating hormone (hFSH) activity (FSA) of human chorionic gonadotropin (hCG) has been proposed for many years (1). FSA was demonstrated in extracts of pregnancy urine and crude or highly purified hCG preparations. Whether FSA is due to cross-contamination of these hormone preparations with hFSH or represents “true” FSA is still a matter of debate. Studies employing immunoprecipitation techniques with polyclonal antisera suggest that the latter is more likely (2). These studies have been carried out using hormone standard preparations of various origin. So far, no investigations have been performed with pregnancy- and tumorderived sera containing high concentrations of hCG.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albert A. Follicle stimulating activity of human chorionic gonadotropin. J Clin Endocrinol Metab 1969; 29: 1504–9.
Siris ES, Nisula BC, Catt KJ, et al. New evidence for intrinsic follicle-stimulating hormone-like activity in human chorionic gonadotropin and luteinizing hormone. Endocrinology 1978; 102: 1356–61.
Berger P, Panmoung W, Khashabi D, Mayregger B, Wick G. Antigenic features of human follicle stimulating hormone delineated by monoclonal antibodies and construction of an immunoradiometric assay. Endocrinology 1988; 123: 2351–9.
Kofler R, Berger P, Wick G. Monoclonal antibodies against hCG, I. Production, specificity and intramolecular binding sites. Am J Reprod Immunol 1982; 160: 212–6.
Schwarz S, Berger P, Nelboeck E, et al. Probing the receptor interaction of glycoprotein hormones with monoclonal antibodies. J Recept Res 1988; 8: 437–53.
Berger P, Klieber R, Panmoung W, Madersbacher S, Wolf H, Wick G. Monoclonal antibodies against the free subunits of human chorionic gonadotropin. J Endocrinol 1990; 125: 301–9.
De Jong FH. Inhibin. Physiol Rev 1988; 68: 555–607.
Morris PL, Vale WW, Cappel S, Bardin CW. Inhibin production by primary Sertoli cell-enriched cultures: regulation by follicle-stimulating hormone, androgens, and epidermal growth factor. Endocrinology 1988; 122: 717–25.
Fingschedt U, Mann K, Clemm C, Nieschlag E. Elevated inhibin levels in patients with malignant teratomas [Abstract]. In: Proc 72nd annu meet Endocr Soc. Atlanta: Endocrine Society, 1990: 167.
McLachlan RI, Finkel DM, Bremner WJ, Snyder PJ. Serum inhibin concentrations before and during gonadotropin treatment in men with hypogonadotropic hypogonadism: physiological and clinical implication. J Clin Endocrinol Metab 1990; 70: 1414–9.
McNeilly A. The control of FSH-secretion. Acta Endocrinol 1988; 288: 31–40.
Mann K, Schneider N, Hörmann R. Thyrotropic activity of acidic isoelectric variants of human chorionic gonadotropin from trophoblastic tumors. Endocrinology 1986; 118: 1558–66.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag New York, Inc.
About this chapter
Cite this chapter
Berger, P., Madersbacher, S., Klieber, R., Wick, G. (1992). Secretion Pattern of FSH in Patients Suffering from Chorionic Gonadotropin-Producing Tumors. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_40
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7103-8_40
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-7105-2
Online ISBN: 978-1-4684-7103-8
eBook Packages: Springer Book Archive