Abstract
The prostate is known to synthesize and secrete various protein hormones, growth factors and neuropeptides, that without any doubt, establish the entity of the prostate as an endocrine organ (1, 2). Our earlier studies had demonstrated the presence of a protein exhibiting inhibin-like activity—prostatic inhibin peptide (PIP)—in prostates of human (3) and animal species (4) that preferentially suppressed synthesis and release of pituitary follicle stimulating hormone (FSH). Since the synthesis and secretion of FSH and inhibin are interdependent (5) and earlier studies also indicated their coexistence in various tissues (6–8), we were prompted to look for FSH in prostates of human and animal species.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Farnsworth WE, Ablin RJ. The prostate as an endocrine gland. FL: CRC Press, 1990.
Ablin RJ, Whyard TC. Immunological implications of select bioactive molecules in the prostate with a known and unknown target. In: Farnsworth WE, Ablin RJ, eds. The prostate as an endocrine gland. FL: CRC Press, 1990: 149–72.
Sathe VS, Sheth NA, Sheth AR, et al. Biosynthesis and localization of inhibin in human prostate. Prostate 1987; 10: 33–43.
Garde SV, Sheth AR. Immunoperoxidase localization of prostatic inhibin peptide in human, monkey, dog and rat prostates. Mat Rec 1989; 223: 181–4.
Hurkadli KS, Sheth AR, Garde SV. Follicle stimulating hormone (FSH) modulating peptides: inhibin related peptides. Ind J Exp Biol 1989; 27: 303–9.
Garde SV, Sheth AR, Kulkarni SA. Cellular distribution of inhibin in marmoset testes during development. Anat Rec 1990.
Garde SV, Sheth AR, Kulkarni SA. FSH in testis of marmosets during development: immunocytochemical localization and de novo biosynthesis. Anat Rec 1990.
Sheth AR, Garde SV, Hurkadli KS, et al. Prostate—a nonclassical source of FSH and inhibin: are these hormones involved in the etiopathology of prostatic tumours? Proc Int Conf Perspectives Primate Reprod Biol. Bangalore, Feb 3–7, 1990.
Hurkadli KS, Shah MG, Pardanani DS, et al. De novo biosynthesis of FSH-like peptide by the human prostate. Life Sci 1990; 47: 391–400.
Hurkadli KS, Mahale SD, Iyer KNS, et al. Enhancement of in vitro release of FSH from rat pituitaries by a synthetic nonapeptide fragment of human seminal plasma inhibin. Life Sci 1989; 45: 1357–63.
Iyer KSN, Mahale SD, Hurkadli KS, et al. A synthetic decapeptide analogue of human seminal plasma inhibin exhibiting specific suppression of follicle stimulating hormone release in rats. Ind J Exp Biol 1989; 27: 10–3.
Hsueh AJW, Bicsak TA, Jia X, et al. Granulosa cells as hormone targets: the role of biologically active follicle stimulating hormone in reproduction. In: Clark JH, ed. Recent progress in hormone research. New York: Academic Press, 1989; 45: 209–77.
Shaha C, Morris PL, Chen CLC, et al. Immunostainable inhibin subunits are in multiple types of testicular cells. Endocrinology 1989; 125: 1941–50.
Logan A. Intracrine regulation at the nucleus—a further mechanism of growth factor activity? J Endocrinol 1990; 125: 339–43.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag New York, Inc.
About this chapter
Cite this chapter
Garde, S.V., Sheth, A.R. (1992). Prostate—An Extrapituitary Source of Follicle Stimulating Hormone. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_29
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7103-8_29
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-7105-2
Online ISBN: 978-1-4684-7103-8
eBook Packages: Springer Book Archive