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Hypergonadotropic Forms of Amenorrhea

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Follicle Stimulating Hormone

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

Circulating concentrations of follicle stimulating hormone (FSH) increase dramatically following both bilateral oophorectomy and the menopause. Thus, by definition, young women with hypergonadotropic amenorrhea should have premature ovarian failure (POF). This belief was based on the findings of Goldenberg et al. (1), who reported that without exception, individuals with FSH levels of greater than 40 mIU/mL 2nd IRP-hMG (International Reference Preparation-human menopausal gonadotropins) had no viable follicles on ovarian biopsy.

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References

  1. Goldenberg RL, Grodin JM, Rodbard D, Ross GT.: Gonadotropins in women with amenorrhea. Am J Obstet Gynecol 1973; 116: 1003–12.

    PubMed  CAS  Google Scholar 

  2. Rebar RW, Erickson GF, Coulam CB.: Premature ovarian failure. In: Gondos B, Riddick D, eds. Pathology of infertility. New York: Thieme-Stratton, 1987: 123–42.

    Google Scholar 

  3. O’Herlihy C, Pepperell RJ, Evans JH.: The significance of FSH elevation in young women with disorders of ovulation. Br Med J 1980; 281: 1447–50.

    Article  PubMed  Google Scholar 

  4. Rebar RW, Erickson GF:, Yen SSC. Idiopathic premature ovarian failure: clinical and endocrine characteristics. Fertil Steril 1982; 37: 35–41.

    PubMed  CAS  Google Scholar 

  5. Aiman J, Smentek C.: Premature ovarian failure. Obstet Gynecol 1985; 66: 9–14.

    PubMed  CAS  Google Scholar 

  6. Hague WM, Tan SL, Adams J, Jacobs HS.: Hypergonadotropic amenorrheaetiology and outcome in 93 young women. Int J Gynaecol Obstet 1987; 25: 121–5.

    Article  PubMed  CAS  Google Scholar 

  7. Rebar RW, Connolly HV.: Clinical features of young women with hypergonadotropic amenorrhea. Fertil Steril 1990; 53: 804–10.

    PubMed  CAS  Google Scholar 

  8. Mattison DR, Evans MI, Schwimmer WB, White BJ, Jensen B, Schulman JD.: Familial premature ovarian failure. Am J Hum Genet 1984; 36: 1341–8.

    PubMed  CAS  Google Scholar 

  9. Starup J, Philip J, Sele V.: Oestrogen treatment and subsequent pregnancy in two patients with severe hypergonadotrophic ovarian failure. Acta Endocrinol (Copenh) 1978; 89: 149–57.

    CAS  Google Scholar 

  10. Coulam CB, Stringfellow S, Hoefnagel D.: Evidence for a genetic factor in the etiology of premature ovarian failure. Fertil Steril 1983; 40: 693–5.

    PubMed  CAS  Google Scholar 

  11. Singh RP, Carr DH.: The anatomy and histology of XO human embryos and fetuses. Anat Rec 1966; 155: 369–81.

    Article  PubMed  CAS  Google Scholar 

  12. Kinch RAH, Plunkett ER, Smout MS, Carr DH.: Primary ovarian failure: a clinicopathological and cytogenetic study. Am J Obstet Gynecol 1965; 91: 63044.

    Google Scholar 

  13. Krauss CM, Turksoy RN, Atkins L, McLaughlin C, Brown LG, Page DC.: Familial premature ovarian failure due to an interstitial deletion of the long arm of the X chromosome. N Engl J Med 1987; 317: 125–31.

    Article  PubMed  CAS  Google Scholar 

  14. Villanueva AL, Rebar RW.: The triple X syndrome and premature ovarian failure. Obstet Gynecol 1983; 62: 70S - 4S.

    PubMed  CAS  Google Scholar 

  15. Day RW, Larson W, Wright SW.: Clinical and cytogenetic studies on a group of females with XXX sex chromosome complements. J Pediatr 1964; 64: 24–33.

    Article  PubMed  CAS  Google Scholar 

  16. Gordon DL, Paulsen CA.: Premature menopause in XO/XX/XXX/XXXX mosaicism. Am J Obstet Gynecol 1967; 97: 85–90.

    PubMed  CAS  Google Scholar 

  17. Harper PS, Dyken PR.: Early onset dystrophia myotonica. Lancet 1972; 2: 53–5.

    Article  PubMed  CAS  Google Scholar 

  18. Biglieri EG, Herron MA, Brust N.: 17-hydroxylase deficiency in man. J Clin Invest 1966; 45: 1946–54.

    Article  PubMed  CAS  Google Scholar 

  19. Goldsmith O, Solomon DH, Horton R.: Hypogonadism and mineralocorticoid excess. The 17-hydroxylase deficiency syndrome. N Engl J Med 1967; 277: 673–7.

    Article  PubMed  CAS  Google Scholar 

  20. Mallin SR.: Congenital adrenal hyperplasia secondary to 17-hydroxylase deficiency. Two sisters with amenorrhea, hypokalemia, hypertension, and cystic ovaries. Ann Int Med 1969; 70: 69–75.

    PubMed  CAS  Google Scholar 

  21. Hoefnagel D, Wurser-Hili D, Child EL.: Ovarian failure in galactosaemia. Lancet 1979; 2: 1197.

    Article  PubMed  CAS  Google Scholar 

  22. Kaufman F, Kogut MD, Donnell GN:, Ovarian failure in galactosaemia. Lancet 1979; 11: 737–8.

    Article  Google Scholar 

  23. Chen Y-T, Mattison DR, Feigenbaum L, Fukui H, Schulman JD.: Reduction in oocyte number following prenatal exposure to a diet high in galactose. Science 1981; 214: 1145–7.

    Article  PubMed  CAS  Google Scholar 

  24. Verp MS.: Environmental causes of ovarian failure. Semin Reprod Endocrinol 1983; 1: 101–11.

    Article  Google Scholar 

  25. Morrison JC, Givens JR, Wiser WL, Fish SA.: Mumps oophoritis: a cause of premature menopause. Fertil Steril 1975; 26: 655–9.

    PubMed  CAS  Google Scholar 

  26. Jick H, Porter J, Morrison AS.: Relation between smoking and age of natural menopause. Lancet 1977; 1: 1354–5.

    Article  PubMed  CAS  Google Scholar 

  27. LaBarbera AR, Miller MM, Ober C, Rebar RW.: Autoimmune etiology in premature ovarian failure. Am J Reprod Immunol Microbiol 1988; 16: 115–22.

    PubMed  CAS  Google Scholar 

  28. Irvine WJ, Chan MMW, Scarth L:, Immunological aspects of premature ovarian failure associated with idiopathic Addison’s disease. Lancet 1968; 2: 883–7.

    Article  PubMed  CAS  Google Scholar 

  29. Vazquez AM, Kenny FM.: Ovarian failure and antiovarian antibodies in association with hypoparathyroidism, moniliasis, and Addison’s and Hashimoto’s diseases. Obstet Gynecol 1973; 41: 414–8.

    PubMed  CAS  Google Scholar 

  30. De Moraes-Ruehsen M, Blizzard RM, Garcia-Bunuel R, Jones GS.: Autoimmunity and ovarian failure. Am J Obstet Gynecol 1972; 112: 693–703.

    PubMed  Google Scholar 

  31. Coulam CB, Ryan RJ.: Premature menopause, I. Etiology. Am J Obstet Gynecol 1979; 133: 639–43.

    CAS  Google Scholar 

  32. McNatty KP, Short RV, Barnes EW, Irvine WJ.: The cytotoxic effect of serum from patients with Addison’s disease and autoimmune ovarian failure on human granulosa cells in culture. Clin Exp Immunol 1975; 22: 378–84.

    PubMed  CAS  Google Scholar 

  33. Chiauzzi V, Cigorraga S, Escobar ME, Rivarola MA, Charreau EH.: Inhibition of follicle-stimulating hormone receptor binding by circulating immunoglobulins. J Clin Endocrinol Metab 1982; 54: 1221–8.

    Article  PubMed  CAS  Google Scholar 

  34. Lucky AW, Rebar RW, Blizzard RM, Goren EM.: Pubertal progression in the presence of elevated serum gonadotropins in girls with multiple endocrine deficiencies. J Clin Endocrinol Metab 1977; 45: 673–8.

    Article  PubMed  CAS  Google Scholar 

  35. Bateman BG, Nunley WC, Kitchin JD:, III. Reversal of apparent premature ovarian failure in a patient with myasthenia gravis. Fertil Steril 1983; 39: 108–10.

    PubMed  CAS  Google Scholar 

  36. Coulam CB, Kempers RD, Randall RV.: Premature ovarian failure: evidence for the autoimmune mechanism. Fenil Steril 1981; 36: 238–40.

    CAS  Google Scholar 

  37. Miller ME, Chatten J.: Ovarian changes in ataxia telangiectasia. Acta Paediatr Scand 1967; 56: 559–61.

    Article  PubMed  CAS  Google Scholar 

  38. Healy DL, Bacher J, Hodgen GD. Thymic regulation of primate fetal ovarian-adrenal differentiation. Biol Reprod 1985; 32: 1127–33.

    Article  PubMed  CAS  Google Scholar 

  39. Volpé R.: Autoimmune thyroid disease. In: Volpé R, ed. Autoimmunity and endocrine disease. New York: Marcel Dekker, 1985: 109–285.

    Google Scholar 

  40. Hill JA, Welch WR, Fans HM, Anderson DJ.: Induction of class II major histocompatibility complex antigen expression in human granulosa cells by interferon gamma: a potential mechanism contributing to autoimmune ovarian failure. Am J Obstet Gynecol 1990; 162: 534–40.

    PubMed  CAS  Google Scholar 

  41. Kim JG, Anderson BE, Rebar RW, LaBarbera AR.: Determination by ELISA of antiovarian antibodies in premature ovarian failure [Abstract]. Proc 45th annu meet Am Fertil Soc, 1989.

    Google Scholar 

  42. Laemmli UK.: Cleavage of structural proteins during the assembly of the head of bacteriophage 14. Nature 1970; 227: 680–5.

    Article  PubMed  CAS  Google Scholar 

  43. Towbin HO, Staehnlin T, Gordon T.: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350–4.

    Article  PubMed  CAS  Google Scholar 

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© 1992 Springer-Verlag New York, Inc.

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Rebar, R.W., Carter, J.M., Kim, J.G., Sites, C.K., Song, D.Y., LaBarbera, A.R. (1992). Hypergonadotropic Forms of Amenorrhea. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_24

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  • DOI: https://doi.org/10.1007/978-1-4684-7103-8_24

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7105-2

  • Online ISBN: 978-1-4684-7103-8

  • eBook Packages: Springer Book Archive

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