Abstract
The pituitary glycoprotein hormone FSH consists of two dissimilar, noncovalently linked polypeptide chains. The α-subunit is common to all three pituitary glycoprotein hormones (FSH, LH, and TSH) and the placental-derived chorionic gonadotropin (CG). The unique β-subunit confers each molecule with its biological specificity. Although all subunits of the gonadotropins are believed to be derived from a common ancestral gene, each subunit is encoded for by a separate gene. The gene structure of the α- and β-subunits is well conserved, with the FSHβ subunit gene structure identified in 3 exons separated by 2 introns. The FSHβ gene is unique among the glycoprotein hormones in possessing a 3′-untranslated region of approximately 1 kb. The importance of this long 3′ tract is unknown, but is potentially involved in mRNA stability.
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© 1992 Springer-Verlag New York, Inc.
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Galway, A.B., LaPolt, P.S., Boime, I., Hsueh, A.J.W. (1992). Recombinant FSH and Regulation of Ovulation. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_17
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DOI: https://doi.org/10.1007/978-1-4684-7103-8_17
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