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Regulation of Ovarian Inhibin and Activin Gene Expression by Gonadotropins

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Follicle Stimulating Hormone

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

Follicle stimulating hormone (FSH) plays a critical role in regulating ovarian function and is a key hormone in initiating follicular recruitment and promoting follicular maturation (1). Additionally, it influences differentiation by modulating steroidogenesis, inducing luteinizing hormone receptors and regulating the synthesis of ovarian hormones, such as inhibin and activin. Inhibin is an important regulator of FSH synthesis and secretion in rats (2), while activin appears to be a paracrine regulator of ovarian function (3, 4) that may also be involved in FSH regulation (5, 6). The study of how these two genes are regulated is important for understanding aspects of the reproductive cycle. This report focuses on the regulation of inhibin and activin gene expression in rat granulosa cells (GC) by gonadotropins.

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Authors
  1. Robin E. Dodson
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  2. Lin Pei
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  3. Ok-Kyong Park
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  4. Joanna C. Dykema
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  5. Kelly E. Mayo
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Editor information

Editors and Affiliations

  1. Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, 60611, Chicago, IL, USA

    Mary Hunzicker-Dunn Ph.D.

  2. Department of Neurobiology and Physiology, Northwestern University, 60201, Evanston, IL, USA

    Neena B. Schwartz Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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Dodson, R.E., Pei, L., Park, OK., Dykema, J.C., Mayo, K.E. (1992). Regulation of Ovarian Inhibin and Activin Gene Expression by Gonadotropins. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_13

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  • DOI: https://doi.org/10.1007/978-1-4684-7103-8_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7105-2

  • Online ISBN: 978-1-4684-7103-8

  • eBook Packages: Springer Book Archive

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