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Follicle Stimulating Hormone pp 156–166Cite as

FSH Regulation of cAMP-Dependent Protein Kinase Regulatory Subunits in Rat and Porcine Ovarian Tissues

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Follicle stimulating hormone (FSH) is essential for ovarian folliculogenesis. In the ovary, high-affinity FSH receptors on granulosa cells (GC) are the specific targets for FSH (1, for review). The end point of FSH action is the induction and/or regulation of multiple physiological responses that result in follicle development and eventually ovulation, the discussions of which are well covered by other authors in this symposium.

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References

  1. Hsueh AJW, Bicsak TA, Jia X-C, et al. Granulosa cells as hormone targets: the role of biologically active follicle-stimulating hormone in reproduction. Recent Prog Horm Res 1989; 45: 209–77.

    PubMed  CAS  Google Scholar 

  2. Beebe SJ, Corbin JD. Cyclic nucleotide-dependent protein kinases. In: Boyer PD, ed. The enzymes. Orlando, FL: Academic Press, 1986; 17: 43–111.

    Google Scholar 

  3. Corbin JD, Kelly SL, Park CR. The distribution and dissociation of cyclic adenosine 3’:5’-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J Biol Chem 1975; 250: 218–25.

    PubMed  CAS  Google Scholar 

  4. McKnight GS, Clegg CH, Uhler MD, et al. Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches. Recent Prog Horm Res 1988; 44: 307–35.

    PubMed  CAS  Google Scholar 

  5. Titani K, Sasagawa T, Ericsson LH, et al. Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3’,5’-phosphate dependent protein kinase. Biochemistry 1984; 23: 4193–9.

    Article  PubMed  CAS  Google Scholar 

  6. Clegg CH, Cadd GG, McKnight GS. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci USA 1988; 85: 3703–7.

    Article  PubMed  CAS  Google Scholar 

  7. Oyen O, Froysa A, Sandberg M, et al. Cellular localization and age-dependent changes in mRNA for cyclic adensoine 3’,5’-monophosphate-dependent protein kinases in rat testis. Biol Reprod 1987; 37: 947–56.

    Article  PubMed  CAS  Google Scholar 

  8. Takio K, Smith SB, Krebs EG, Walsh KA, Titani K. Amino acid sequence of the regulatory subunit of bovine type II adenosine cyclic 3’,5’-phosphate dependent protein kinase. Biochemistry 1984; 23: 4200–6.

    Article  PubMed  CAS  Google Scholar 

  9. Scott JD, Glaccum MB, Zoller MJ, et al. The molecular cloning of a type H regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain. Proc Natl Acad Sci USA 1987; 84: 5192–6.

    Article  PubMed  CAS  Google Scholar 

  10. Jahnsen T, Hedin L, Kidd VJ, et al. Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells. J Biol Chem 1986; 261: 12352–61.

    PubMed  CAS  Google Scholar 

  11. Jahsen T, Hedin L, Lohmann SM, Walter U, Richards JS. The neural type II regulatory subunit of cAMP-dependent protein kinase is present and regulated by hormones in the rat ovary. J Biol Chem 1986; 261: 6637–9.

    Google Scholar 

  12. Kurten RC, Navre M, Gaddy-Kurten D, et al. Induction of adenosine 3’, 5’monophosphate-dependent protein kinase subunits during adipogenesis in vitro. Endocrinology 1988; 123: 2408–18.

    Article  PubMed  CAS  Google Scholar 

  13. Erlichman J, Sarkar D, Fleischer N, Rubin CS. Identification of two subclasses of type II cAMP-dependent protein kinases. Neural-specific and non-neural protein kinases. J Biol Chem 1980; 255: 8179–84.

    PubMed  CAS  Google Scholar 

  14. Hartl FT, Roskoski R, Jr. Cyclic adenosine 3’:5’-monophosphate-dependent protein kinase. Comparison of type II enzymes from bovine brain, skeletal muscle and cardiac muscle. J Biol Chem 1983; 258: 3950–5.

    PubMed  CAS  Google Scholar 

  15. Weldon SL, Mumby MC, Taylor SS. The regulatory subunit of neural cAMPdependent protein kinase II represents a unique gene product. J Biol Chem 1985; 260: 6440–8.

    PubMed  CAS  Google Scholar 

  16. Stein JC, Rubin CS. Isolation and sequence of a tryptic peptide containing the autophosphorylation site of the regulatory subunit of bovine brain protein kinase II. J Biol Chem 1985; 260: 10991–5.

    PubMed  CAS  Google Scholar 

  17. Schwartz DA, Rubin CS. Identification and differential expression of two forms of regulatory subunits (RH) of cAMP-dependent protein kinase II in Friend erythroleukemic cells. J Biol Chem 1985; 260: 6296–303.

    PubMed  CAS  Google Scholar 

  18. Richards JS, Rolfes AI. Hormonal regulation of cyclic AMP binding to specific receptor proteins in rat ovarian follicles. J Biol Chem 1980; 255: 5481–9.

    PubMed  CAS  Google Scholar 

  19. Ratoosh SL, Lifka J, Hedin L, Jahnsen T, Richards JS. Hormonal regulation of the synthesis and mRNA content of the regulatory subunit of cyclic AMP-dependent protein kinase type II in cultured rat ovarian granulosa cells. J Biol Chem 1987; 262: 7306–13.

    PubMed  CAS  Google Scholar 

  20. Richards JS, Haddox M, Tash JS, Walter U, Lohmann S. Adenosine 3’,5’monophosphate-dependent protein kinase and granulosa cell responsiveness to gonadotropins. Endocrinology 1984; 114: 2190–8.

    Article  PubMed  CAS  Google Scholar 

  21. Richards JS, Kirchick HJ. Changes in content and phosphorylation of cytosol proteins in luteinizing ovarian follicles and corpora lutea. Biol Reprod 1984; 30: 737–51.

    Article  PubMed  CAS  Google Scholar 

  22. Richards JS, Sehgal N, Tash JS. Changes in content and cAMP-dependent phosphorylation of specific proteins in granulosa cells of preantral and preovulatory ovarian follicles and in corpora lutea. J Biol Chem 1983; 258: 5227–32.

    PubMed  CAS  Google Scholar 

  23. Darbon JM, Knecht M, Ranta T, Dufau ML, Catt KJ. Hormonal regulation of cyclic AMP-dependent protein kinase in cultured ovarian granulosa cells. Effects of follicle-stimulating hormone and gonadotropin-releasing hormone. J Biol Chem 1984; 259: 14778–82.

    PubMed  CAS  Google Scholar 

  24. Ratoosh SL, Richards S. Regulation of the content and phosphorylation of RH by adenosine 3’,5’-monophosphate, follicle-stimulating hormone, and estradiol in cultured granulosa cells. Endocrinology 1985; 117: 917–27.

    Article  PubMed  CAS  Google Scholar 

  25. Jahsen T, Lohmann SM, Walter U, Hedin L, Richards JS. Purification and characterization of hormone-regulated isoforms of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovaries. J Biol Chem 1985; 260: 15980–7.

    Google Scholar 

  26. Hedin L, McKnight GS, Lifka J, Durica JM, Richards JS. Tissue distribution and hormonal regulation of messenger ribonucleic acid for regulatory and catalytic subunits of adenosine 3’,5’-monophosphate-dependent protein kinases during ovarian follicular development and luteinization in the rat. Endocrinology 1987; 120: 1928–35.

    Article  PubMed  CAS  Google Scholar 

  27. Hunzicker-Dunn M, Maizels ET, Kern LC, Ekstrom RC, Constaninou AI. Separation of the complexes formed between the regulatory and catalytic subunits of cyclic adenosine monophosphate-dependent protein kinase and topoisomerase I activity in preovulatory follicle-enriched immature rat ovaries. Mol Cell Endocrinol 1989; 3: 780–9.

    Article  CAS  Google Scholar 

  28. Lowry OW, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265–75.

    PubMed  CAS  Google Scholar 

  29. Hunzicker-Dunn M, Jungmann RA, Evely L, Hadawi GL, Maizels ET, West DE. Modulation of soluble ovarian adenosine 3’,5’-monophosphate-dependent protein kinase activity during prepubertal development of the rat. Endocrinology 1984; 115; 302–11.

    Article  PubMed  CAS  Google Scholar 

  30. Hunzicker-Dunn M. Lorenzini NA, Lynch LL, West DE. Coelution of the type II holoenzyme form of cAMP-dependent protein kinase with regulatory subunits of the type I form of cAMP-dependent protein kinase. J Biol Chem 1985; 260: 13360–9.

    PubMed  CAS  Google Scholar 

  31. Roskoski R, Jr. Assays of protein kinase. Methods in Enzymol 1983; 99: 3–6.

    Article  CAS  Google Scholar 

  32. Corbin JD, Sugden PH, West L, Flockhart DA, Lincoln TM, McCarthy D. Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3’:5’-monophosphate-dependent protein kinase. J Biol Chem 1978; 253: 3997–4003.

    PubMed  CAS  Google Scholar 

  33. Hunzicker-Dunn M. Selective activation of rabbit ovarian protein kinase isozymes in rabbit ovarian follicles and corpora lutea. J Biol Chem 1981; 256: 12185–93.

    PubMed  CAS  Google Scholar 

  34. Rudolph SA, Krueger BK. Endogenous protein phosphorylation and dephosphorylation. Adv Cyclic Nucleotide Protein Phosphorylation Res 1979; 10: 107–33.

    CAS  Google Scholar 

  35. Schwartz DA, Rubin CS. Regulation of cAMP-dependent protein kinase subunit levels in Friend erythroleukemic cells. J Biol Chem 1983; 258: 777–84.

    PubMed  CAS  Google Scholar 

  36. Zoller MJ, Kerlavage AR, Taylor SS. Structural comparisons of cAMP-dependent protein-kinases I and II from porcine skeletal muscle. J Biol Chem 1979; 254: 2408–12.

    PubMed  CAS  Google Scholar 

  37. Erlichman J, Rubin CS, Rosen OM. Physical properties of a purified cyclic adenosine 3’:5’-monophosphate-dependent protein kinase from bovine heart muscle. J Biol Chem 1973; 248: 7607–9.

    PubMed  CAS  Google Scholar 

  38. Cobb CE, Beth AH, Corbin JD. Purification and characterization of an inactive form of cAMP-dependent protein kinase containing bound cAMP. J Biol Chem 1987; 262: 16566–74.

    PubMed  CAS  Google Scholar 

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Authors
  1. Deborah A. DeManno
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  2. Mary Hunzicker-Dunn
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Editor information

Editors and Affiliations

  1. Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, 60611, Chicago, IL, USA

    Mary Hunzicker-Dunn Ph.D.

  2. Department of Neurobiology and Physiology, Northwestern University, 60201, Evanston, IL, USA

    Neena B. Schwartz Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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DeManno, D.A., Hunzicker-Dunn, M. (1992). FSH Regulation of cAMP-Dependent Protein Kinase Regulatory Subunits in Rat and Porcine Ovarian Tissues. In: Hunzicker-Dunn, M., Schwartz, N.B. (eds) Follicle Stimulating Hormone. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7103-8_12

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  • DOI: https://doi.org/10.1007/978-1-4684-7103-8_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7105-2

  • Online ISBN: 978-1-4684-7103-8

  • eBook Packages: Springer Book Archive

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