Abstract
During their differentiation from stem cells and precursors B lymphocytes reach a stage when they become resting. These resting B lymphocytes can be activated into cell cycle again when they meet antigen or polyclonal activators. This paper gives a synopsis of the reactions that lead to activation of B cells from the resting state and that control successive B cell cycles.
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References
Andersson, J., Sjöberg, O. and Möller, G. 1972, Induction of immunoglobulin and antibody synthesis in vitro by lipopolysacchardies. Eur. J. Immunol. 2:349–353.
Andersson, J., Bullock, W.W. and Melchers, F. 1974, Inhibition of mitogenic stimulation of mouse lymphocytes by anti-mouse immunoglobulin antibodies. I. Mode of action. Eur. J. Immunol. 4:715–718.
Andersson, J., Coutinho, A., Lernhardt, W. and Melchers, F. 1977, Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B-ylmphocyte. Cell 10:27–34.
Claman, H.N., Chaperon, E.A. and Triplett, R.F. 1966, Thymus-marrow cell combinations. Synergism in antibody production. Soc. Exp. Biol. & Med. 122:1167–1171.
Corbel, C. and Melchers, F. 1984, The synergism of accessory cells and of soluble α-factors derived from them in the activation of B cells to proliferation. Immunol. Rev. 78:51–74.
Davies, A.J.S., Leuchars, E., Wallis, V., Marchant, R. and Elliott, E.V. 1967, The failure of thymus-derived cells to produce antibody. Transplantation 5:222–230.
Erdei, A., Melchers, F., Schulz, T. and Dierich, M. 1985, The action of human C3 in soluble or cross-linked form with resting and activated murine B lymphocytes. Eur. J. Immunol. 15:184–188.
Frade, R., Crevon, M.C., Barel, M., Vazquez, A., Krikorian, L., Charriaut, C. and Galanaud, P. 1985, Enhancement of human B cell proliferation by an antibody to the C3d receptor, the gp 140 molecule. Eur. J. Immuno1. 15:73–76.
Harada, N., Kikuchi, Y., Tominaga, A., Takaki, S. and Takatsu, K. 1985, BCGFII activity on activated B cells of a purified murine T cell-replacing factors (TRF). J. Immunol. 130: No. 5 2219–2224.
Honjo, T., Nakai, S., Nishida, Y., Kataoka, T., Yamawaki-Kataoka, Y., Takhashi, N., Obata, M., Shimiuzu, A., Yaoita, Y., Nikaido, T. and Ishida, N. 1981. Immunol. Rev. 59:5–32.
Iscove, N.N. and Melchers, F. 1978, Complete replacement of serum by albumin, transferrin, iron and soybean lipid in cultures of lipopoly-saccharide-activated B lymphocytes. J. Exp. Med. 147:923–933.
Katz, D.H., Hamaoka, T., Dorf, M.E. and Benacerraf, B. 1973, Cell interactions between histocompatible T and B lymphocytes. III. Demonstration that the H2-gene complex determines successful physiologic lymphocyte interactions. Proc. Natl. Sci. USA 70:2624–2628.
Lanzavecchia, A. 1985, Antigen-specific interaction between T and B cells. Nature 314:537–539.
Leclercq, L., Cambier, J.C., Mishal, Z., Julius, M.H. and Theze, J. 1985, Supernatant from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis and progression through cell cycle. Submitted.
Leptin, M., Potash, M.H., Grützmann, R., Heusser, C., Schulman, M., Köhler, G. and Melchers, F. 1984, Monoclonal antibodies specific for murine IgM I. Characterization of antigenic determinants on the four constant domains of the μ-heavy chain. Eur. J. Immunol. 14, 534–542.
Leptin, M. 1985, Monoclonal antibodies specific for murine IgM. II. Activation of B lymphocytes by monoclonal antibodies specific for the four constant domains of IgM. Eur. J. Immunol. 15:131–137.
Melchers, F. 1985, Murine B cell cycle control and its deregulations in NZW. NZB and BXSB mice. In: Proceedings of a Workshop on Primary Immunodeficiency Diseases, Gmunden Austria, Elsevier Amsterdam (in press).
Melchers and Andersson. 1974a, Early changes in immunoglobulin M synthesis after mitogenic stimulation of bone marrow-derived lymphocytes. Biochemistry 13:4645–4653.
Melchers, F., Andersson, J. 1974b, Changes in synthesis, turnover and secretion, and in numbers of molecules on the surface of B cells after mitogenic stimulation. Eur. J. Immunol. 4:181–188.
Melchers, F., Andersson, J., Lernhardt, W. and Schreier, M.H. 1980, B cells induced by antigen-activated T cell help factors. Eur. J. Immunol. 10:669–685.
Melchers, F., Braun, D. and Galanos, C. 1975, The lipoprotein of the outer membrane of Escherichia coli: A B-lymphocyte mitogen. J. Exp. Med. 142:473–482.
Melchers, F., Corbel, C., Leptin, M. and Lernhardt, W. 1985, Activation and cell cycle control of murine B lymphocytes. J. Cell. Sci. Suppl. 3 (in press).
Melchers, F., Erdei, A., Schulz, T and Dierich, M. 1985, Growth control of activated, synchronized murine B cells by the C3d fragment of human complement. Nature 317:264–267.
Melchers, F., Lernhardt, W. 1985, Three restriction points in the cell cycle of activated murine B lymphocytes, Proc. Natl. Acad. Sci. USA (in press).
Miller, R.G. and Phillips, R.A. 1969, Separation of cells by velocity sedimentation. J. Cell. Physiol. 73:191–202.
Mitchell, G.F. and Miller, J.F.A.P. 1968, Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J. Exp. Med. 128:821–837.
Mosier, D.E. 1967, A requirement for two cell types for antibody formation in vitro. Science 158:1573–1574.
Mosier, D.H. and Subbarao, B. 1982, Thymus-independent antigens: complexity of B lymphocyte activation revealed. Immunol. Today 3:217–222.
Ohara, J. and Paul, W.E. 1985, Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315:333–335.
Ohara, J., Lahet, S., Inmann, J. and Paul, W.E. 1985, Partial purification of murine B-cell stimulatory factor (BSF)-1. J. Immunol. (in press).
Oliver, K., Noelle, R.J., Uhr, J.W., Krammer, P.H. and Vitetta, E.S. 1985, B cell growth factor (BCGF I or BSPp1) is a differentiation factor for resting B cells and may not induce cell growth. Proc. Natl. Acad. Sci. USA, (in press).
Parker, D.C. 1975, Stimulation of mouse lymphocytes by insoluble antimouse immunoglobulins. Nature 258:365.
Rock, K.L., Benacerraf, B. and Abbas, A.K. 1984, Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J. Exp. Med. 160:1102–1113.
Ross, G.D. 1980, Analysis of the different types of leukocyte membrane complement receptors and their interaction with the complement system. J. Immunol. Meth. 37:197–211.
Sprent, J. 1978, Role of H-2 gene products in the function of T helper cells from normal and chimeric mice measured in vivo. Immunol. Rev. 42:108–137.
Takatsu, K., Harada, N., Hara, Y., Takahama, Y., Yamada, G., Dobashi, K. and Hamaoka, T. 1985, Purification and physicochemical characterization of murine T cell replacing factor (TRF). J. Immunol. 134:382–388.
Tony, H.-P. and Parker, D.C. 1985, Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of anti immunoglobulin presented by small B lymphocytes. J. Exp. Med. 161:223–241.
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© 1986 Plenum Press, New York
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Melchers, F. (1986). Control of the Mitotic B Cell Cycle: Facts and Speculations. In: Ferrarini, M., Pernis, B. (eds) The Molecular Basis of B-Cell Differentiation and Function. NATO ASI Series, vol 123. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7035-2_8
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DOI: https://doi.org/10.1007/978-1-4684-7035-2_8
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