Abstract
Our laboratory has focused on the study of various aspects of DNA rearrangements that affect the organization and expression of immunoglobulin heavy chain genes. Using a mouse myeloma cell line, MPC11 (IgG2b/k), we have isolated variants making various types of altered heavy chains, including class switch variants producing γ2a heavy chains, hybrid (γ2b–γ2a) heavy chain producers, and short γ2b heavy chain producers.
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References
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© 1986 Plenum Press, New York
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Calvo, CF., Birshtein, B.K. (1986). Acquired Alterations Around the Cε Gene in Cultured Mouse Myeloma Cells. In: Ferrarini, M., Pernis, B. (eds) The Molecular Basis of B-Cell Differentiation and Function. NATO ASI Series, vol 123. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7035-2_2
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DOI: https://doi.org/10.1007/978-1-4684-7035-2_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7037-6
Online ISBN: 978-1-4684-7035-2
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