Abstract
The ability of several bacteria or bacterial cell products to act as polyclonal B-cell activators (PBAs) is known for many years. Among bacterial PBAs active on human B cells, Staphylococcus aureus Cowan first strain (SAC) and its cell wall component, Staphylococcal protein A (SpA), is undoubtedly the most interesting one. In the first part of of this paper the mechanisms by which SAC bacteria activate human B cells are discussed. In the second part, data obtained by the application of SAC bacteria to the study of events involved in the induction of human B cells from the resting state to immunoglobulin (Ig)-secreting cells are reported.
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© 1986 Plenum Press, New York
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Romagnani, S. (1986). Application of the Staphylococcus Aureus Bacteria to the Study of Human B Cell Proliferation and Differentiation. In: Ferrarini, M., Pernis, B. (eds) The Molecular Basis of B-Cell Differentiation and Function. NATO ASI Series, vol 123. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7035-2_11
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DOI: https://doi.org/10.1007/978-1-4684-7035-2_11
Publisher Name: Springer, Boston, MA
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