Skip to main content
SpringerLink
Log in
Book cover

The Rhabdoviruses pp 129–166Cite as

Rhabdovirus Genomes and Their Products

  • Chapter

Part of the book series: The Viruses ((VIRS))

Abstract

Rhabdoviruses are relatively simple, membrane-enveloped viruses containing a single-stranded RNA genome. The genomic RNA is the negative sense—i.e., complementary to the messenger RNAs (mRNAs)—and is noninfectious. The virus particles must therefore contain an RNA-dependent RNA polymerase to generate the mRNAs (Baltimore et al., 1970). Rhabdoviruses have a bacilliform, bullet-, or cone-shaped morphology and are known to infect vertebrates, invertebrates, and plants. The composition of various rhabdoviruses has been reviewed by McSharry (1979). The virus particles contain a helical, nucleocapsid core composed of the genomic RNA and protein. Generally, three proteins termed N (nucleocapsid), NS (originally indicating nonstructural), and L (large) are found to be associated with the nucleocapsid. An additional matrix (M) protein lies within the membrane envelope, perhaps interacting both with the membrane and the nucleocapsid core. A single glycoprotein (G) species spans the membrane and forms the spikes on the surface of the virus particle.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abraham, G., and Banerjee, A. K., 1976, Sequential transcription of the genes of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 73: 1504.

    Article  PubMed  CAS  Google Scholar 

  • Abraham, G., Rhodes, D. P., and Banerjee, A. K., 1975, The 5’ terminal structure of the methylated mRNA synthesized in vitro by vesicular stomatitis virus, Cell 5: 51.

    Article  PubMed  CAS  Google Scholar 

  • Arnheiter, H., Davis, N. L., Wertz, G., Schubert, M., and Lazzarini, R. A., 1985, Role of the nucleocapsid protein in regulating vesicular stomatitis virus RNA synthesis, Cell 41: 259.

    Article  PubMed  CAS  Google Scholar 

  • Ball, L. A., and White, C. N., 1976, Order of transcription of genes of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 73: 442.

    Article  PubMed  CAS  Google Scholar 

  • Baltimore, D., Huang, A. S., and Stampfer, M., 1970, Ribonucleic acid synthesis of vesicual stomatitis virus. II. An RNA plymerase in the virion, Proc. Natl. Acad. Sci. U.S.A. 66: 572.

    Article  PubMed  CAS  Google Scholar 

  • Banerjee, A. I., 1980, 5’ Terminal cap structure in eucaryotic messenger ribonucleic acids, Microbiol. Rev. 44: 175.

    Google Scholar 

  • Banerjee, A. K., and Rhodes, D. P., 1973, In vitro synthesis of RNA that contains polyadenylate by virion-associated RNA polymerase of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 70: 3566.

    CAS  Google Scholar 

  • Banerjee, A. K., Abraham, G., and Colonno, R. J., 1977, Vesicular stomatitis virus: Mode of transcription, J. Gen. Virol. 34: 1.

    Article  PubMed  CAS  Google Scholar 

  • Banerjee, A. K., Rhodes, D. P., and Gill, D. S., 1984, Complete nucleotide sequence of the mRNA coding for the N protein of vesicular stomatitis virus (New Jersey serotype), Virology 137: 432.

    PubMed  CAS  Google Scholar 

  • Bell, J., and Prevec, L., 1985, Phosphorylation sites on phosphoprotein NS of vesicular stomatitis virus, J. Virol. 54: 697.

    PubMed  CAS  Google Scholar 

  • Bell, J., Brown, E. G., Takayesu, D., and Prevec, L., 1984, Protein kinase activity associated with immunoprecipitates of the vesicular stomatitis virus phosphoprotein NS, Virology 132: 229.

    Article  PubMed  CAS  Google Scholar 

  • Bergmann, J. E., Tokuyasu, K. T., and Singer, S. J., 1981, Passage of an integral membrane protein, the vesicular stomatitis virus glycoprotein, through the Golgi apparatus en route to the plasma membrane, Proc. Natl. Acad. Sci. U.S.A. 78: 1746.

    Article  PubMed  CAS  Google Scholar 

  • Bishop, D. H. L., and Roy, P., 1971, Kinetics of RNA synthesis by vesicular stomatitis virus particles, J. Mol. Biol 57: 513.

    Article  PubMed  CAS  Google Scholar 

  • Blumberg, B. M., and Kolakofsky, D., 1981, Intracellular vesicular stomatitis virus leader RNAs are found in nucleocapsid structures, J. Virol. 40: 568.

    PubMed  CAS  Google Scholar 

  • Blumberg, B. M., Leppert, M., and Kolakofsky, D., 1981, Interaction of VSV leader RNA and nucleocapsid protein may control VSV genome replication, Cell 23: 837.

    Article  PubMed  CAS  Google Scholar 

  • Blumberg, B. M., Giorgi, C., and Kolakofsky, D., 1983, N protein of vesicular stomatitis virus selectively encapsidates leader RNA in vitro, Cell 32: 559.

    CAS  Google Scholar 

  • Blumberg, B. M., Giorgi, C., Rose, K., and Kolakofsky, D. 1984, Preparation and analysis of the nucleocapsid proteins of VSV and Sendai virus and analysis of the Sendai virus leader-np gene region, J. Gen. Virol. 65: 769–779.

    Article  PubMed  CAS  Google Scholar 

  • Carroll, A., and Wagner, R., 1979, Role of the membrane (M) protein in endogenous inhibition of in vitro transcription by vesicular stomatitis virus, J. Virol. 29: 134.

    Google Scholar 

  • Chatis, P. A., and Morrison, T. G., 1979, Vesicular stomatitis virus glycoprotein is anchored to intracellular membranes near its carboxyl end and is proteolytically cleaved at its amino terminus, J. Virol. 29: 957.

    Google Scholar 

  • Chatis, P. A., and Morrison, T. G., 1982, Characterization of the soluble glycoprotein released from VSV infected cells, J. Virol. 45: 80.

    Google Scholar 

  • Clinton, G. M., and Huang, A. S., 1981, Distribution of phosphoserine, phosphothreonine and phosphotyrosine in proteins of vesicular stomatitis virus, Virology 108: 510.

    Article  PubMed  CAS  Google Scholar 

  • Clinton, G. M., Burge, B. W., and Huang, A. S., 1978a, Effects of phosphorylation and pH on the association of NS protein with vesicular stomatitis virus cores, J. Virol. 27: 340.

    PubMed  CAS  Google Scholar 

  • Clinton, G., Little, S., Hagen, F., and Huang, A., 1978b, The matrix protein of VSV regulates transcription, Cell 15: 1455.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, G., Atkinson, P. and Summers, D., 1971, Interaction of VSV structural proteins with HeLa cell plasma membranes, Nature (London), 231: 121.

    Article  CAS  Google Scholar 

  • Colonno, R. J., and Banerjee, A. K., 1976, A unique RNA species involved in initiation of vesicular stomatitis virus RNA transcription in vitro, Cell 8: 197.

    Article  PubMed  CAS  Google Scholar 

  • Colonno, R. J., and Banerjee, A. K., 1978a, Complete nucleotide sequence of the leader RNA synthesized in vitro by vesicular stomatitis virus, Cell 15: 93.

    Article  PubMed  CAS  Google Scholar 

  • Colonno, R. J., and Banerjee, A. K., 1978b, Nucleotide sequence of the leader RNA of the New Jersey serotype of vesicular stomatitis virus, Nucleic Acids Res. 51: 4165.

    Article  Google Scholar 

  • Combard, A., and Printz-Ané, C., 1979, Inhibition of vesicular stomatitis virus transcriptase complex by the virion envelope protein, Biochem. Biophys. Res. Commun. 88: 117.

    Article  PubMed  CAS  Google Scholar 

  • Crimmins, D. L., Mehard, W. B., and Schlesinger, S., 1983, Physical properties of a soluble form of the glycoprotein of vesicular stomatitis virus at neutral and acidic pH, Biochemistry 22:5790.

    Google Scholar 

  • De, B. P., and Banerjee, A. K., 1983, Specific binding of guanosine 5’-diphosphate with the NS protein of vesicular stomatitis virus, Biochem. Biophys. Res. Commun. 114: 138.

    Article  PubMed  CAS  Google Scholar 

  • De, B. P., and Banerjee, A. K., 1984, Specific interactions of vesicular stomatitis virus L and NS proteins with heterologous genome ribonucleoprotein template lead to mRNA synthesis in vitro, J. Virol 51: 628.

    PubMed  CAS  Google Scholar 

  • De, B. P., Thornton, G. B., Luk, D., and Banerjee, A. K., 1982, Purified matrix protein of vesicular stomatitis virus blocks viral transcription in vitro, Proc. Natl. Acad. Sci. U.S.A. 79: 7137.

    Article  PubMed  CAS  Google Scholar 

  • Dietzschold, B., Wiktor, T., Wunner, W., and Varrichio, A., 1983, Chemical and immu-nological analysis of the rabies virus soluble glycoprotein, Virology 124: 330.

    Article  PubMed  CAS  Google Scholar 

  • Doolittle, R. F., 1981, Similar amino acid sequences: Chance or common ancestry?, Science 214: 149.

    Article  PubMed  CAS  Google Scholar 

  • Dubovi, E. J., and Wagner, R. R., 1977, Spatial relationships of the proteins of vesicular stomatitis virus: Induction of reversible oligomers by cleavable protein cross-linkers and oxidation, /. Virol. 22: 500.

    CAS  Google Scholar 

  • Ehrenfeld, E., and Summers, D. F., 1972, Adenylate-rich sequences in vesicular stomatitis virus messenger ribonucleic acids, J. Virol. 12: 683.

    Google Scholar 

  • Emerson, S. U., 1982, Reconstitution studies detect a single polymerase entry site on the vesicular stomatitis virus genome, Cell 31: 635.

    Article  PubMed  CAS  Google Scholar 

  • Emerson, S. U., and Wagner, R. R., 1972, Dissociation and reconstitution of the transcriptase and template activities of vesicular stomatitis B and T virions, J. Virol. 10: 297.

    PubMed  CAS  Google Scholar 

  • Emerson, S. U., and Yu, Y.-H., 1975, Both NS and L proteins are required for in vitro RNA synthesis by vesicular stomatitis virus, J. Virol. 15: 1348.

    PubMed  CAS  Google Scholar 

  • Emerson, S. U., Dierks, P. M., and Parsons, J. T., 1977, In vitro synthesis of a unique RNA species by a T particle of vesicular stomatitis virus, /. Virol. 23: 708.

    CAS  Google Scholar 

  • Etchison, J., Robertson, J., and Summers, D., 1977, Partial structural analysis of the oligosaccharide moieties of the VSV glycoprotein by sequential and enzymatic degradation, Virology 78: 375.

    Article  PubMed  CAS  Google Scholar 

  • Flamand, A., 1970, Etude génétique de la stomatite vesiculaire• Classement de mutants thermosensibles spontanées en groupes de complementation, J. Gen. Virol. 8: 187.

    Article  PubMed  CAS  Google Scholar 

  • Flamand, A., and Delagneau, J. F., 1978, Transcriptional mapping of rabies virus in vivo, J. Virol. 28: 518.

    PubMed  CAS  Google Scholar 

  • Florkiewicz, R., and Rose, J., 1984, A cell line expressing the VSV glycoprotein fuses at low pH, Science 225: 721.

    Article  PubMed  CAS  Google Scholar 

  • Florkiewicz, R., Smith, A., Bergmann, J. E., and Rose, J. K., 1983, Isolation of stable mouse cell lines that express cell surface and secreted forms of the vesicular stomatitis virus glycoprotein, J. Cell Biol. 97: 1381.

    Article  PubMed  CAS  Google Scholar 

  • Gallione, C. J., and Rose, J. K., 1983, Nucleotide sequence of a cDNA clone encoding the entire glycoprotein from the New Jersey serotype of vesicular stomatitis virus, J. Virol. 46: 162.

    PubMed  CAS  Google Scholar 

  • Gallione, C. J., and Rose, J. K., 1985, A single amino acid substitution in a hydrophobic domain causes temperature-sensitive cell surface transport of a mutant viral glycoprotein, J. Virol. 54: 374–382.

    PubMed  CAS  Google Scholar 

  • Gallione, C. J., Greene, J. R., Iverson, L. E., and Rose, J. K., 1981, Nucleotide sequences of the mRNAs encoding the vesicular stomatitis virus N and NS proteins, J. Virol. 39: 529.

    CAS  Google Scholar 

  • Garreis-Wabnitz, C., and Kruppa, J., 1984, Intracellular appearance of a glycoprotein in VSVinfected BHK cells lacking the membrane-anchoring oligopeptide of the viral G-protein, Eur. Mol. Biol. Org. J. 3: 1469.

    CAS  Google Scholar 

  • Gibson, R. S., Schlesinger, and Kornfeld, S., 1979, The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures, J. Biol. Chem. 254: 3600–3607.

    CAS  Google Scholar 

  • Gill, D. S., and Banerjee, A. K., 1985, Vesicular stomatitis virus NS proteins: Structural similarity without extensive sequence homology, J. Virol. 55: 60.

    PubMed  CAS  Google Scholar 

  • Giorgi, C., Blumberg, B., and Kolakofsky, D., 1983, Sequence determination of the ( + ) leader RNA regions of the VSV Chandipura, Cocal and Piry serotype genomes, J. Virol. 46: 125.

    PubMed  CAS  Google Scholar 

  • Gluzman, Y., 1981, SV40-transformed simian cells support the replication of early SV40 mutants, Cell 23: 175.

    Article  PubMed  CAS  Google Scholar 

  • Grinnell, B., and Wagner, R. R., 1983, Comparative inhibition of cellular transcription by vesicular stomatitis virus serotypes New Jersey and Indiana. Role of each viral leader RNA, J. Virol. 48: 88.

    PubMed  CAS  Google Scholar 

  • Grinnell, B., and Wagner, R. R., 1984, Nucleotide sequence and secondary structure of vesicular stomatitis leader RNA and homologous DNA involved in inhibition of DNA-dependent transcription, Cell 36: 533.

    Article  PubMed  CAS  Google Scholar 

  • Gupta, K. C., and Kingsbury, D. W., 1984, Complete sequences of the intergenic and mRNA start signals in the Sendai virus genome: Homologies with the genome of vesicular stomatitis virus, Nucleic Acids Res. 12: 3829.

    Article  PubMed  CAS  Google Scholar 

  • Gupta, K. C., and Roy, P., 1980, Alternate capping mechanisms for transcription of spring viremia of carp virus: Evidence for independent mRNA initiation, J. Virol. 33: 292.

    PubMed  CAS  Google Scholar 

  • Herman, R. C., Adler, S., Lazzarini, R. A., Colonno, R. J., Banerjee, A. K., and Westphal, H., 1978, Intervening polyadenylate sequences in RNA transcripts of vesicular stomatitis virus, Cell 15: 587.

    Article  PubMed  CAS  Google Scholar 

  • Herman, R. C., Schubert, M., Keene, J. D., and Lazzarini, R. A., 1980, Polycistronic vesicular stomatitis virus RNA transcripts, Proc. Natl. Acad. Sci. U.S.A. 77: 4662.

    Article  PubMed  CAS  Google Scholar 

  • Horikami, S. M., and Moyer, S. A., 1982, Host range mutants of vesicular stomatitis virus defective in in vitro RNA methylation, Proc. Natl. Acad. Sci. U.S.A. 79: 7694.

    Article  PubMed  CAS  Google Scholar 

  • Hsu, C.-H., Morgan, E. M., and Kingsbury, D. W., 1982, Site-specific phosphorylation regulates the transcriptive activity of vesicular stomatitis virus NS protein, J. Virol. 43: 104.

    PubMed  CAS  Google Scholar 

  • Huang, A. S., and Manders, E. K., 1972, Ribonucleic acid synthesis of vesicular stomatitis virus. IV. Transcription by standard virus in the presence of defective interfering particles, J. Virol. 9: 909.

    PubMed  CAS  Google Scholar 

  • Hubbard, S. C., and Ivatt, R. J., 1981, Synthesis and processing of asparagine-linked oligosaccharides, Annu. Rev. Biochem. 50: 555.

    Article  PubMed  CAS  Google Scholar 

  • Hunt, D. M., 1983, Vesicular stomatitis virus mutant with altered polyadenylic acid polymerase activity in vitro, J. Virol. 46: 788.

    PubMed  CAS  Google Scholar 

  • Hunt, D. M., Emerson, S. U., and Wagner, R. R., 1976, RNA temperature-sensitive mutants of vesicular stomatitis virus: L-protein thermosensitivity accounts for transcriptase restriction of group I mutants, J. Virol. 18: 596.

    PubMed  CAS  Google Scholar 

  • Hunt, D. M., Smith, E. F., and Buckley, D. W., 1984, Aberrant polyadenylation by a vesicular stomatitis virus mutant is due to an altered L protein, J. Virol. 52: 515.

    PubMed  CAS  Google Scholar 

  • Imblum, R. L., and Wagner, R. R., 1974, Protein kinase and phosphoproteins of vesicular stomatitis virus, J. Virol. 13: 113.

    PubMed  CAS  Google Scholar 

  • Imblum, R. L., and Wagner, R. R., 1975, Inhibition of viral transcriptase by immunoglobulin directed against the nucleocapsid NS protein of vesicular stomatitis virus, J. Virol. 15: 1357.

    PubMed  CAS  Google Scholar 

  • Irving, R. A., and Ghosh, H. P., 1982, Shedding of vesicular stomatitis virus soluble glycoprotein by removal of carboxyl-terminal peptide, J. Virol. 42: 322.

    PubMed  CAS  Google Scholar 

  • Irving, R. A., Toneguzzo, F., Rhee, S. H., Hofmann, T., and Ghosh, H. P., 1979, Synthesis and assembly of membrane glycoproteins: Presence of leader peptide in nonglycosylated precursor of membrane glycoprotein of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 76: 570.

    Article  PubMed  CAS  Google Scholar 

  • Isaac, C. L., and Keene, J. D., 1982, RNA polymerase associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus, J. Virol. 43: 241.

    PubMed  CAS  Google Scholar 

  • Iverson, L. E., and Rose, J. K., 1981, Localized attenuation and discontinuous synthesis during vesicular stomatitis virus transcription, Cell 23: 477.

    Article  PubMed  CAS  Google Scholar 

  • Iverson, L., E., and Rose, J. K., 1982, Sequential synthesis of 5’ proximal vesicular stomatitis virus mRNA sequences, J. Virol. 44: 356.

    CAS  Google Scholar 

  • Kang, C. Y., and Prevec, L., 1970, Proteins of vesicular stomatitis virus II Immunological comparisons of viral antigens, J. Virol. 6: 20.

    PubMed  CAS  Google Scholar 

  • Keene, J. D., Schubert, M., Lazzarini, R. A., and Rosenberg, M., 1978, Nucleotide sequence homology at the 3’ termini of RNA from vesicular stomatitis virus and its defective interfering particles, Proc. Natl. Acad. Sci. U.S.A. 75: 3225.

    Article  PubMed  CAS  Google Scholar 

  • Keene, J. D., Schubert, M., and Lazzarini, R. A., 1979, Terminal sequences of vesicular stomatitis virus RNA are both complementary and conserved, J. Virol. 32: 167.

    PubMed  CAS  Google Scholar 

  • Keene, J. D., Schubert, M., and Lazzarini, R. A., 1980, Intervening sequences between the leader region and the nucleocapsid gene of vesicular stomatitis virus RNA, J. Virol. 33: 789.

    PubMed  CAS  Google Scholar 

  • Keene, J. D., Chien, I. M., and Lazzarini, R. A., 198la, Vesicular stomatitis virus defective interfering particle containing a muted internal leader RNA gene, Proc. Natl. Acad. Sci. U.S.A. 78: 2090.

    Google Scholar 

  • Keene, J. D., Thornton, B. J., and Emerson, S. U., 198 lb, Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene, Proc. Natl. Acad. Sci. U.S.A. 78: 6191.

    Google Scholar 

  • Kelley, J. M., Emerson, S. U., and Wagner, R. R., 1972, The glycoprotein of vesicular stomatitis virus is the antigen that gives rise to and reacts with neutralizing antibody, J. Virol. 10 :1231.

    Google Scholar 

  • Kingsbury, D. W., 1974, The molecular biology and paramyxoviruses, Med. Microbiol. Immunol. 160: 73.

    Article  PubMed  CAS  Google Scholar 

  • Kingsbury, D. W., Hsu, C.-H., and Morgan, E. M., 1981, A role for NS protein phosphorylation in vesicular stomatitis virus transcription, in: The Replication of Negative Strand Viruses ( D. H. Bishop and R. W. Compans, eds.), p. 821, Elsevier/North-Holland, New York.

    Google Scholar 

  • Kingsford, L., and Emerson, S. U., 1980, Transcriptional activities of different phosphorylated species of NS protein purified from vesicular stomatitis virions and cytoplasm of infected cells, J. Virol. 33: 1097.

    PubMed  CAS  Google Scholar 

  • Knipe, D., Baltimore, D., and Lodish, H., 1977a, Separate pathways of maturation of the major structural proteins of vesicular stomatitis virus, J. Virol. 21: 1128.

    PubMed  CAS  Google Scholar 

  • Knipe, D., Baltimore, D., and Lodish, H., 1977b, Maturation of viral proteins in cells infected with temperature-sensitive mutants of vesicular stomatitis virus, J. Virol. 21: 1149.

    PubMed  CAS  Google Scholar 

  • Kolakofsky, D., 1982, Isolation of vesicular stomatitis virus defective interfering genomes with different amounts of 5’ terminal complementarity, J. Virol. 41: 566.

    PubMed  CAS  Google Scholar 

  • Kurath, G., and Leong, J. C., 1985, Characterization of infectious hematopoietic necrosis virus mRNA species reveals a nonvirion rhabdovirus protein, J. Virol. 53: 462.

    PubMed  CAS  Google Scholar 

  • Kurath, G., Ahern, K. G., Pearson, G. C., and Leong, J. C., 1985, Molecular cloning of the six mRNA species of infectious hematopoietic necrosis virus, a fish rhabdovirus, and gene order determination by R-loop mapping, J. Virol. 53: 469.

    PubMed  CAS  Google Scholar 

  • Kurilla, M. G., and Keene, J. D., 1983, The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies, Cell 34: 837.

    Article  PubMed  CAS  Google Scholar 

  • Kurilla, M. G., Pinwica-Worms, H., and Keene, J. D., 1982, Rapid and transient localization of the leader RNA of VSV in the nuclei of infected cells, Proc. Natl. Acad. Sci. U.S.A. 79: 5240.

    Article  PubMed  CAS  Google Scholar 

  • Kurilla, M. G., Cabradilla, C. D., Holloway, B. P., and Keene, J. D., 1984, Nucleotide sequence and host La protein interactions of rabies virus leader RNA, J. Virol. 50: 773.

    PubMed  CAS  Google Scholar 

  • Lazzarini, R. A., Keene, J. D., and Schubert, M., 1981, The origins of defective interfering particles of the negative-strand RNA viruses, Cell 26: 145.

    Article  PubMed  CAS  Google Scholar 

  • Leavitt, R., Schlesinger, S., and Kornfeld, S., 1977a, Tunicamycin inhibits glycosylation and multiplication of Sindbis and vesicular stomatitis viruses, J. Virol. 21: 375–385.

    PubMed  CAS  Google Scholar 

  • Leavitt, R., Schlesinger, S., and Kornfeld, S., 1977b, Impaired intracellular migration and altered solubility of nonglycosylated glycoproteins of vesicular stomatitis virus and Sindbis virus, J. Biol. Chem. 252: 9018–9023.

    PubMed  CAS  Google Scholar 

  • Leppert, M., and Kolakofsky, D., 1980, Effect of defective interfering particles on plus-and minus-strand leader RNAs in vesicular stomatitis virus-infected cells, J. Virol. 35: 704.

    PubMed  CAS  Google Scholar 

  • Leppert, M., Rittenhouse, L., Perrault, J, Summers, D. F., and Kolakofsky, D., 1979, Plus and minus strand leader RNAs in negative strand virus-infected cells, Cell 18: 235.

    Article  Google Scholar 

  • Lingappa, V. R., Katz, F. N., Lodish, H. F., and Blobel, G., 1978, A signal sequence for insertion of a transmembrane glycoprotein, J. Biol. Chem. 253: 8867.

    Google Scholar 

  • Little, S. P., and Huang, A. S., 1977, Synthesis and distribution of vesicular stomatitis virus-specific polypeptides in the absence of progeny production, Virology 81: 37.

    Article  PubMed  CAS  Google Scholar 

  • Machamer, C., Florkiewicz, R., and Rose, J., 1985, A single N-linked oligosaccharide at either of the two normal sites promotes cell surface transport of the vesicular stomatitis virus glycoprotein, Mol. Cell. Biol. 5: 3074.

    PubMed  CAS  Google Scholar 

  • Magee, A. I., Koyama, A. H., Malfer, C., Wen, D., and Schlesinger, M., 1984, Release of fatty acids from viral glycoproteins, Biochim. Biophys. Acta 798: 156–166.

    Article  PubMed  CAS  Google Scholar 

  • Marcus, P. I., and Sekellick, M. J., 1975, Cell killing by viruses. II. Cell killing by vesicular stomatitis virus: A requirement for virion-derived transcription, Virology, 63: 176.

    Article  PubMed  CAS  Google Scholar 

  • Martinet, C., Combard, A., Printz-Ané, C., and Printz, P., 1979, Envelope proteins and replication of vesicular stomatitis virus: In vivo effects of RNA’ temperature sensitive mutations on viral RNA synthesis, J. Virol. 29: 123.

    PubMed  CAS  Google Scholar 

  • Masters, P. S., and Samuel, C. E., 1984, Detection of in vivo synthesis of polycistronic mRNAs of vesicular stomatitis virus, Virology 134: 277.

    Article  PubMed  CAS  Google Scholar 

  • McGeoch, D. J., 1979, Structure of the gene N:gene NS intercistronic junction in the genome of the vesicular stomatitis virus, Cell 17: 3199.

    Article  Google Scholar 

  • McGeoch, D. J., and Dolan, A., 1979, Sequence of 200 nucleotides at the 3’ terminus of the RNA genome of vesicular stomatitis virus, Nucleic Acids Res. 6: 3199.

    Google Scholar 

  • McGowan, J. J., and Wagner, R. R., 1981, Inhibition of cellular DNA synthesis by vesicular stomatitis virus, J. Virol. 38: 356.

    PubMed  CAS  Google Scholar 

  • McGowan, J. J., Emerson, S. U., and Wagner, R. R., 1982, The plus-strand leader RNA of VSV inhibits DNA-dependent transcription of adenovirus and SV40 genes in a soluble whole-cell extract, Cell 28: 325.

    Article  PubMed  CAS  Google Scholar 

  • McSharry, J. J., 1979, The lipid envelope and chemical composition of Rhabdoviruses, in: The Rhabdoviruses, Vol. I (D. H. L. Bishop, ed.), p. 107, CRC Press, Boca Raton, Florida. Meier, E., Harmison, G. G., Keene, J. D., and Schubert, M., 1984, Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs, J. Virol. 51: 515.

    Google Scholar 

  • Mellon, M. G., and Emerson, S. U., 1978, Rebinding of transcriptase component (L and NS proteins) to the nucleocapsid template of vesicular stomatitis virus, J. Virol. 27: 560.

    PubMed  CAS  Google Scholar 

  • Morgan, E. M., and Kingsbury, D. W., 1981, Association of the transcriptase and RNA methyltransferase activities of vesicular stomatitis virus with the L protein, in: The Replication of Negative Strand Viruses, ( D. H. L. Bishop and R. W. Compans, eds.), pp. 815–820, Elsevier/North-Holland, New York.

    Google Scholar 

  • Morrison, T. G., McQuain, C. O., and Simpson, D., 1978, Assembly of viral membranes: Maturation of the vesicular stomatitis virus glycoprotein in the presence of tunicamycin, J. Virol. 28: 368.

    PubMed  CAS  Google Scholar 

  • Moyer, S. A., and Gatchell, S. H., 1979, Intracellular events in the replication of defective interfering particles of vesicular stomatitis virus, Virology 92: 168.

    Article  PubMed  CAS  Google Scholar 

  • Moyer, S. A., and Summers, D. F., 1974, Phosphorylation of VSV in vivo and in vitro, J. Virol. 13: 455.

    PubMed  CAS  Google Scholar 

  • Moyer, S. A., Abraham, G., Adler, R., and Banerjee, A. K., 1975, Methylated and blocked 5’ termini in vesicular stomatitis virus in vivo mRNAs, Cell 5: 59.

    Article  PubMed  CAS  Google Scholar 

  • Naito, S., and Ishihima, A., 1976, Function and structure of RNA polymerase from vesicular stomatitis virus, /. Biol. Chem. 251: 4307.

    CAS  Google Scholar 

  • Newcomb, W., and Brown, J., 1981, Role of the vesicular stomatitis virus matrix protein in maintaining the viral nucleocapsid in the condensed form found in native virions, /. Virol. 39: 295.

    CAS  Google Scholar 

  • Obijeski, J. F., and Simpson, R. W., 1974, Conditional lethal mutants of vesicular stomatitis virus. H. Synthesis of virus-specific polypeptides in non-permissive cells infected with “RNA—” host restricted mutants, Virology 57: 369.

    Article  PubMed  CAS  Google Scholar 

  • Ongradi, J., Cunningham, C., and Szilagyi, J. F., 1985, The role of polypeptides L and NS in the transcription process of vesicular stomatitis virus New Jersey using the temperature-sensitive mutant is El, I. Gen. Virol. 66: 1011.

    Article  CAS  Google Scholar 

  • Patton, J. T., Davis, N. L., and Wertz, G. W., 1984, N protein alone satisfies the requirement for protein synthesis during RNA replication of vesicular stomatitis virus, J. Virol. 49: 303.

    PubMed  CAS  Google Scholar 

  • Peluso, R. W., and Moyer, S. A., 1984, Vesicular stomatitis virus proteins required for the in vitro replication of defective interfering particle genome RNA, in: Nonsegmented Negative Strand Viruses (Paramyxoviruses and Rhabdoviruses) ( D. H. L. Bishop and R. W. Compans, eds.), p. 153, Academic Press, San Francisco.

    Google Scholar 

  • Perrault, J., 1981, Origin and replication of defective interfering particles, Curr. Top. Microbiol. Immunol. 93: 151–207.

    Article  PubMed  CAS  Google Scholar 

  • Perrault, J., Semier, B. L., Leavitt, R. W., and Holland, J. J., 1978, Inverted complementary terminal sequences in defective interfering particle RNAs of vesicular stoma-titis virus and their possible role in autointerference, in: Negative Strand Viruses and the Host Cell ( B. W. J. Mahy and R. D. Barry, eds.), pp. 527–538, Academic Press, New York.

    Google Scholar 

  • Pringle, C. R., 1975, Conditional lethal mutants of vesicular stomatitis virus, Curr. Topics Mi cro bi ol. Immunol. 69: 85.

    Article  CAS  Google Scholar 

  • Pringle, C. R., 1978, The tdCE and hrCE phenotypes: Host range mutants of vesicular stomatitis virus in which polymerase function is affected, Cell 15: 597.

    Article  PubMed  CAS  Google Scholar 

  • Pringle, C. R., 1982, The genetics of vesiculoviruses, Arch. Virol. 72: 1.

    Article  PubMed  CAS  Google Scholar 

  • Rao, D. D., and Huang, A. S., 1979, Synthesis of a small RNA in cells coinfected by standard and defective interfering particles of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 76: 3472.

    Google Scholar 

  • Reading, C. L., Penhoet, E., and Ballou, C. E., 1978, Carbohydrate structure of vesicular stomatitis virus glycoprotein, J. Biol. Chem. 253: 5600.

    PubMed  CAS  Google Scholar 

  • Reichmann, M. E., Villarreal, L. P., Kohne, D., Lesnam, J. A., and Holland, J. J., 1974, RNA polymerase activity and poly(A) synthesizing activity in defective T particles of vesicular stomatitis virus, Virology 58: 240.

    Article  PubMed  CAS  Google Scholar 

  • Riedel, H., Kondor-Koch, C., and Garoff, H., 1984, Cell surface expression of fusogenic vesicular stomatitis virus G protein from cloned cDNA, Eur. Mol. Biol. Org. J. 3: 1477.

    CAS  Google Scholar 

  • Robertson, J. S., Schubert, M., and Lazzarini, R. A., 1981, Polyadenylation sites of influenza virus mRNA, J. Virol. 38: 157.

    PubMed  CAS  Google Scholar 

  • Rose, J. K., 1975, Heterogeneous 5’ terminal structures occur on vesicular stomatites virus mRNAs, J. Biol. Chem. 250: 8098.

    PubMed  CAS  Google Scholar 

  • Rose, J. K., 1977, Nucleotide sequences of ribosome recognition sites in messenger RNAs of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 74: 3672.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J. K., 1978, Complete sequences of ribosome recognition sites on messenger RNAs of vesicular stomatitis virus, Cell 14: 345.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J. K., 1980, Complete intergenic and flanking gene sequences from the genome of vesicular stomatitis virus, Cell 19: 415.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J. K., and Bergmann, J. E., 1982, Expression from cloned cDNA of cell surface and secreted forms of the glycoprotein of vesicular stomatitis virus in eucaryotic cells, Cell 30: 753.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J. K., and Bergmann, J. E., 1983, Altered cytoplasmic domains affect intracellular transport of the vesicular stomatitis virus glycoprotein, Cell 34: 513.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J. K., and Galion, C., 1981, Nucleotide sequences of the mRNAs encoding the VSV G and M proteins as determined from cDNA clones containing the complete coding regions, J. Virol. 39: 519.

    PubMed  CAS  Google Scholar 

  • Rose, J. K. and Shafferman, A., 1981, Conditional expression of the vesicular stomatitis virus glycoprotein in Escherichia coli, Proc. Natl. Acad. Sci. U.S.A. 78: 6670.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J. K., Lodish, H. F., and Brock, M., 1977, Giant heterogeneous polyadenylic acid on vesicular stomatitis virus mRNA synthesized in vitro in the presence of S-adenosylhomocysteine, J. Virol. 21: 683.

    PubMed  CAS  Google Scholar 

  • Rose, J. K., Welch, W. J., Sefton, B. M., Esch, F. S., and Ling, N. C., 1980. Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus, Proc. Natl. Acad. Sci. U.S.A. 77: 3884.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J. K., Doolittle, R. F., Anilionis, A., Curtis, P. J., and Wunner, W. H., 1982, Homology between the glycoproteins of vesicular stomatitis virus and rabies virus, J. Virol. 43: 361.

    PubMed  CAS  Google Scholar 

  • Rose, J. K., Adams, G., and Gallione, C., 1984, The presence of cysteine in the cytoplasmic domain of the vesicular stomatitis virus glycoprotein is required for palmitate addition, Proc. Natl. Acad. Sci. U.S.A. 81: 2050.

    Article  PubMed  CAS  Google Scholar 

  • Rothman, J. E., and Lodish, H. F., 1977, Synchronized transmembrane insertion and glycosylation of a nascent membrane protein, Nature (London) 269: 775.

    Google Scholar 

  • Rowlands, D. J., 1979, Sequences of vesicular stomatitis virus RNA in the region coding for leader RNA, N protein RNA and their junction, Proc. Natl. Acad. Sci. U.S.A. 76: 4793.

    Google Scholar 

  • Sanchez, A., De, B. P., and Banerjee, A. K., 1985, In vitro phosphorylation of NS protein by the L protein of vesicular stomatitis virus, J. Gen. Virol. 66: 1025.

    CAS  Google Scholar 

  • Schlegel, R., and Wade, M., 1984, A synthetic peptide corresponding to the NFL- terminus of VSV glycoprotein is a pH-dependent hemolysin, J. Biol. Chem. 259: 4691.

    PubMed  CAS  Google Scholar 

  • Schlegel, R., and Wade, M., 1985, Biologically active peptides of the VSV glycoprotein, J. Virol. 53: 319.

    PubMed  CAS  Google Scholar 

  • Schlesinger, M. J., and Mailer, C., 1982, Cerulenin blocks fatty acid acylation of glycoproteins and inhibits VSV and Sindbis virus particle formation, J. Biol. Chem. 257: 9887.

    PubMed  CAS  Google Scholar 

  • Schmidt, M. F. G., and Schlesinger, M. J., 1979, Fatty acid binding to vesicular stomatitis virus glycoprotein: A new type of post-translational modification of the viral glycoprotein, Cell 17: 813–819.

    Google Scholar 

  • Schubert, M., and Lazzarini, R. A., 1981, In vivo transcription of the 5’-terminal extracistronic region of vesicular stomatitis virus RNA, J. Virol. 38: 256.

    CAS  Google Scholar 

  • Schubert, M., and Lazzarini, R A, 1982, In vitro transcription of vesicular stomatitis virus: Incorporation of deoxyguanosine and deoxycytidine, and formation of deoxyguanosine caps, J. Biol. Chem. 257: 2968.

    CAS  Google Scholar 

  • Schubert, M., Keene, J. D., Lazzarini, R. A., and Emerson, S. U., 1978, The complete sequence of a unique RNA species synthesized by a DI particle of VSV, Cell 15: 103.

    Article  PubMed  CAS  Google Scholar 

  • Schubert, M., Keene, J. D., and Lazzarini, R. A., 1979, A specific internal RNA polymerase recognition site of VSV RNA is involved in the generation of DI particles, Cell 18: 749.

    Article  PubMed  CAS  Google Scholar 

  • Schubert, M., Keene, J. D., Herman, R. C., and Lazzarini, R. A., 1980, Site on the vesicular stomatitis virus genome specifying polyadenylation and the end of the L gene mRNA, J. Virol. 34: 550.

    PubMed  CAS  Google Scholar 

  • Schubert, M., Harmison, G., and Meier, E., 1984, Primary structure of the vesicular stomatitis virus polymerase (L) gene: Evidence for a high frequency of mutations, J. Virol. 51: 505.

    PubMed  CAS  Google Scholar 

  • Schubert, M., Harmison, G. G., Richardson, C. D., and Meier, E., 1985, Expression of a cDNA encoding a functional, 241 kilodalton vesicular stomatitis virus RNA polymerase, Proc. Natl. Acad. Sci. U.S.A. 82: 7984.

    Article  PubMed  CAS  Google Scholar 

  • Semler, B. L., Perrault, J., Abelson, J., and Holland, J. J., 1978, Sequence of a RNA templated by the 3’-OH RNA terminus of defective interfering particles of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 75: 4704.

    Article  PubMed  CAS  Google Scholar 

  • Simonsen, C. C., Batt-Hymphries, S., and Summers, D. F., 1979, RNA synthesis of vesicular stomatitis virus-infected cells: In vivo regulation of replication, J. Virol. 31: 124.

    PubMed  CAS  Google Scholar 

  • Simpson, R. W., and Obijeski, J. F., 1974, Conditional lethal mutants of vesicular stomatitis virus. I. Phenotypic characterization of single and double mutants exhibiting host restriction and temperature sensitivity, Virology 57: 357.

    Article  PubMed  CAS  Google Scholar 

  • Sprague, J., Condra, J. H., Arnheiter, H., and Lazzarini, R. A., 1983, Expression of a recombinant DNA gene coding for the vesicular stomatitis virus nucleocapsid protein, J. Virol. 45: 773.

    PubMed  CAS  Google Scholar 

  • Szilagyi, J. F., Pringle, C. R., and MacPherson, T. M., 1977, Temperature-dependent host range mutation in vesicular stomatitis virus affecting polypeptide L, J. Virol. 22: 381.

    PubMed  CAS  Google Scholar 

  • Testa, D., and Banerjee, A. K., 1977, Two methyl transferase activities in the purified virions of vesicular stomatitis virus, J. Virol. 24: 786.

    PubMed  CAS  Google Scholar 

  • Thomas, D., Newcomb, W. W., Brown, J. C., Wall, J. S., Hainfield, J. F., Trus, B. L., and Alasdair, S. C., 1985, Mass and molecular composition of vesicular stomatitis virus: A scanning transmission electron microscopy analysis, J. Virol. 54: 598.

    PubMed  CAS  Google Scholar 

  • Venkatesan, S., and Moss, B., 1982, Eucaryotic mRNA capping enzyme—guanylate covalent intermediate, Proc. Natl. Acad. Sci. U.S.A. 79: 340.

    Article  PubMed  CAS  Google Scholar 

  • Villarreal, L. P., and Holland, J. J., 1973, Synthesis of poly(A) in vitro by purified virions of vesicular stomatitis virus, Nature(London) 245: 17.

    Google Scholar 

  • Wang, D., Furuichi, Y., and Shatkin, A. J., 1982, Covalent guanylyl intermediate formed by HeLa cell mRNA capping enzyme, Mol. Cell. Biol. 2: 993.

    PubMed  CAS  Google Scholar 

  • Weck, P. K., and Wagner, R. R., 1978, Inhibition of RNA synthesis in mouse myeloma cells infected with vesicular stomatitis virus, J. Virol. 25: 720.

    Google Scholar 

  • Weck, P. K., and Wagner, R. R., 1979, Transcription of vesicular stomatitis virus is required to shut off cellular RNA synthesis, J. Virol. 30: 410.

    PubMed  CAS  Google Scholar 

  • Weck, P. K., Carroll, A. R., Shattuck, D. M., and Wagner, R. R., 1979, Use of U.V. irradiation to identify the genetic information of vesicular stomatitis virus responsible for shutting off cellular RNA synthesis, J. Virol. 30: 746.

    PubMed  CAS  Google Scholar 

  • Wertz, G. W., and Levine, M., 1973, RNA synthesis by vesicular stomatitis virus and a small plaque mutant: Effects of cycloheximide, J. Virol. 12: 253.

    PubMed  CAS  Google Scholar 

  • Wertz, G. W., and Youngner, J. S., 1972, Inhibition of protein synthesis in L cells infected with vesicular stomatitis virus, J. Virol. 9: 85.

    PubMed  CAS  Google Scholar 

  • White, J., Kielian, M., and Helenius, A., 1983, Viral fusion proteins, Q. Rev. Biol. Phys. 16: 151.

    CAS  Google Scholar 

  • Wilusz, J., Kurilla, M. G., and Keene, J. D., 1983, A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus, Proc. Natl. Acad. Sci. U.S.A. 80: 5827.

    Article  PubMed  CAS  Google Scholar 

  • Wu, F.-S., and Lucas-Lenard, J., 1980, Inhibition of RNA accumulation in mouse L cells infected with VSV requires viral RNA transcription, Biochemistry 19: 804.

    Article  PubMed  CAS  Google Scholar 

  • Zakowski, J. J., and Wagner, R. R., 1980, Localization of membrane associated proteins in vesicular stomatitis virus by use of hydrophobic membrane probes and cross-linking reagents, J. Virol. 36: 93.

    PubMed  CAS  Google Scholar 

  • Zakowski, J. J., Petri, W. A., and Wagner, R. R., 1981, Role of matrix protein in assembling the membrane of vesicular stomatitis virus: Reconstitution of matrix protein with negatively charged phospholipid vesicles, Biochemistry 23: 3902.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pathology and Cell Biology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    John Rose

  2. Laboratory of Molecular Genetics, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, 20892, USA

    Manfred Schubert

Authors
  1. John Rose
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manfred Schubert
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Microbiology and Cancer Center, University of Virginia School of Medicine, 22908, Charlottesville, Virginia, USA

    Robert R. Wagner

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Rose, J., Schubert, M. (1987). Rhabdovirus Genomes and Their Products. In: Wagner, R.R. (eds) The Rhabdoviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7032-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7032-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7034-5

  • Online ISBN: 978-1-4684-7032-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation