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Separation and Characterization of Myelin Proteins

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Functional and Structural Proteins of the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 32))

Abstract

Within the group of plasma membranes, isolated and studied until now, the myelin membrane has a typical characteristically low protein content of 20 percent (3,15,18) and a protein composition of reduced complexity. By work on isolated cerebral myelin, the encephalitogenic basic protein was directly shown to be a myelin protein (17, 18). Autilio (2) applied gel filtration in chloroformmethanol and obtained a further myelin protein fraction comprising 55 to 65 percent of total myelin proteins. This protein fraction had an amino acid composition almost identical to the classical Folch-Lees proteolipid protein (13) which was extracted from cerebral white matter and subjected to a purification step.

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Author information

Authors and Affiliations

  1. Division of Neurochemistry, Max-Planck-Institut of Psychiatry, Munich, Germany

    E. Mehl

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  1. E. Mehl
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Editor information

Editors and Affiliations

  1. Department of Neurochemistry, Institute of Neurology, London, England

    A. N. Davison

  2. Centre de Neurochemie du CNRS, Strasbourg, France

    P. Mandel  & I. G. Morgan  & 

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© 1972 Plenum Press, New York

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Mehl, E. (1972). Separation and Characterization of Myelin Proteins. In: Davison, A.N., Mandel, P., Morgan, I.G. (eds) Functional and Structural Proteins of the Nervous System. Advances in Experimental Medicine and Biology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6979-0_13

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  • DOI: https://doi.org/10.1007/978-1-4684-6979-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6981-3

  • Online ISBN: 978-1-4684-6979-0

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