Abstract
The DNA extracted from polyoma virus exhibits certain properties which have not been reported for other viral base-paired DNA’s.1 The DNA renatures monomolecularly. The loss of helical configuration does not impair biological activity. Heating at 100° for 10–20 min followed by rapid cooling does not reduce the infective titer. Dulbecco has given evidence suggesting that a fraction of the polyoma DNA molecules are cyclic.2 This form would in part account for the above properties.
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Weil, R., Vinograd, J. (1976). The Cyclic Helix and Cyclic Coil Forms of Polyoma Viral DNA. In: Schiminovich, S. (eds) The Biology of DNA Tumor Viruses. Milestones in Current Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6970-7_3
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DOI: https://doi.org/10.1007/978-1-4684-6970-7_3
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