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The Role and Regulation of the Jun Proteins in Response to Phorbol Ester and UV Light

  • Chapter
Inducible Gene Expression, Volume 1

Part of the book series: Progress in Gene Expression ((PRGE))

Abstract

The genetic program of all biological systems including the cells of mammals is extensively determined by the conditions of the immediate environment. Mammalian cells are exposed to many environmental cues such as cytokines or growth factors, as well as extraorganismic influences, such as heat, high concentrations of heavy metal ions, chemical carcinogens such as alkylating agents, tumor promoters, and radiation. A major adverse effect of the latter harmful substances is damage to DNA. By analogy to the bacterial system where exposure to DNA-damaging agents induces the SOS response (Little and Mount, 1982; Walker, 1985), mammalian cells actively respond to those agents by activating DNA repair enzymes and initiating a transcriptional induction response known as the UV response (Karin and Herrlich, 1989; Ronai et al, 1990; Holbrook and Fornance, 1991; Herrlich et al, 1992).

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  1. Peter Angel
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  1. Institute of Biochemistry, Albert-Ludwigs-University Freiburg, Hermann-Herder-Str. 7, D-79104, Freiburg i.Br., Germany

    P. A. Baeuerle

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Angel, P. (1995). The Role and Regulation of the Jun Proteins in Response to Phorbol Ester and UV Light. In: Baeuerle, P.A. (eds) Inducible Gene Expression, Volume 1. Progress in Gene Expression. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6840-3_3

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  • DOI: https://doi.org/10.1007/978-1-4684-6840-3_3

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