Skip to main content
SpringerLink
Log in

CREM, a master-switch in the nuclear response to cAMP signaling

  • Chapter
Inducible Gene Expression, Volume 2

Part of the book series: Progress in Gene Expression ((PRGE))

  • 120 Accesses

Abstract

The regulation of gene expression by specific signal transduction pathways is tightly connected to the cell phenotype. The response elicited by a given transduction pathway will vary according to the cell type. The finding that most of the known nuclear oncogenes encode proteins involved in the regulation of gene expression inspired the concept that the aberrant expression of some key genes could cause cellular transformation or altered proliferation (Lewin, 1991). The study, and ultimately the understanding, of these processes will help us, it is hoped, to unravel the profound changes that cause cancer and by the same token the physiology of normal growth.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andrisani OM, Hayes TE, Roos B, Dixon JE (1987): Identification of the promoter sequences involved in the cell-specific expression of the rat somatostatin gene. Nucleic Acids Res 15: 5715–5728

    PubMed  CAS  Google Scholar 

  • Auwerx J, Sassone-Corsi P (1991): IP-1: A dominant inhibitor of fos/jun whose activity is modulated by phosphorylation. Cell 64: 983–993

    PubMed  CAS  Google Scholar 

  • Axelrod, J (1988): The pineal gland: a neurochemical transducer Science 184: 1 091

    Google Scholar 

  • Benbrook DM, Jones NC (1990): Heterodimer formation between CREB and Jun proteins. Oncogene 5: 295–302

    PubMed  CAS  Google Scholar 

  • Berkowitz LA, Riabowol KT, Gilman MZ (1989): Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol Cell Biol 9: 4272–4281

    PubMed  CAS  Google Scholar 

  • Berridge M J (1987): Inositol trisphosphate and diacy lglycerol: two interacting second messengers. Ann Rev Biochem 56: 159–193

    PubMed  CAS  Google Scholar 

  • Biownstein M, Axelrod J (1974): Pineal gland: 24-hour rhythm in norepinephrine turnover. Science 184: 165

    Google Scholar 

  • Borrelli E, Heyman R, Arias C, Sawchenko P, Evans RM (1989): Transgenic mice with inducible dwarfism. Nature 339: 538–541

    PubMed  CAS  Google Scholar 

  • Borrelli E, Montmayeur JP, Foulkes NS, Sassone-Corsi P (1992): Signal transduction and gene control: the cAMP pathway. Critical Rev Oncogenesis 3: 321–338

    CAS  Google Scholar 

  • Bravo R, Zerial M, Toschi L, Schurmann M, Muller R, Hirai SI, Yaniv M, Almendral JM, Ryseck RP (1988): Identification of growth factor-inducible genes in mouse fibroblasts. Cold Spring Harbor Symp Quant Biol 53: 901–905

    PubMed  CAS  Google Scholar 

  • Bullitt E (1989): Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation. Brain Res 391–397

    Google Scholar 

  • Busch SJ, Sassone-Corsi P (1990): Dimers, leucine zippers and DNA binding domains. Trends Genet 6: 36–40

    PubMed  CAS  Google Scholar 

  • Cambier JC, Newell NK, Justement LB, McGuire JC, Leach KL, Chen ZZ (1987): Ia binding ligand and cAMP stimulates nuclear translocation of PKC in β lymphocytes. Nature 327: 629–632

    PubMed  CAS  Google Scholar 

  • Carter DA, Murphy D (1990): Regulation of c-fos and c-jun expression in the rat supraoptic nucleus. Mol Cell Neurobiol 10: 435–446

    CAS  Google Scholar 

  • Cattanach BM, Iddon CA, Charlton HM, Chiappa SA, Fink G (1977): Gonadotropin releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 269: 338–340

    PubMed  CAS  Google Scholar 

  • Cole TJ, Copeland NC, Gilbert DJ, Jenkins NA, SchĂĽtz G, Ruppert S (1992): The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis and chromosomal localization. Genomics 13: 974.

    PubMed  CAS  Google Scholar 

  • Comb M, Birnberg NC, Seasholtz A, Herbert E, Goodman HM (1986): A cyclic-AMP and Phorbol Ester-inducible DNA Element. Nature 323: 353–356

    PubMed  CAS  Google Scholar 

  • Courey AJ, Tjian R (1989): Analysis of Spl in vivo reveals multiple transcriptional domains, including a novel glutaminÄ™ activation motif. Cell 55: 887–898

    Google Scholar 

  • Craft, CM, Morgan, WW, Reiter RJ (1984): 24 hour changes in catecholamine synthesis in rat and hamster pineal glands. Neuroendocrinology 38: 193

    Google Scholar 

  • Dash PK, Karl KA, Colicos MA, Prywes R, Kandel ER (1991): cAMP response element-binding protein is activated by Ca2+/calmodulin-as well as cAMP-dependent protein kinase. Proc Natl Acad Sci USA 88: 5061–5065

    Google Scholar 

  • deGroot RP, Sassone-Corsi P (1993): Hormonal control of gene expression: multiplicity and versatility of cyclic adenosine 3′, 5′-monophosphate-responsive nuclear regulators. Mol Endocrinol 7: 145–153

    CAS  Google Scholar 

  • de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P (1993a): Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12: 3903–3911

    PubMed  Google Scholar 

  • de Groot RP, Derua R, Goris J, Sassone-Corsi P (1993b): Phosphorylation and negative regulation of the transcriptional activator CREM by p34cdc2. Mol Endocrinol 7: 1495–1501

    PubMed  Google Scholar 

  • Delegeane A, Ferland L, Mellon PL (1987): Tissue specific enhancer of the human glycoprotein hormone a-subunit gene: dependence on cyclic AMP-inducible elements. Mol Cell Biol 7: 3994–4002

    PubMed  CAS  Google Scholar 

  • Delmas V, Laoide BM, Masquilier D, de Groot RP, Foulkes NS, Sassone-Corsi P (1992): Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator (CREM) generates regulators with opposite functions. Proc Natl Acad Sci USA 89: 4226–4230

    PubMed  CAS  Google Scholar 

  • Delmas V, van der Hoorn F, Mellström B, JĂ©gou B, Sassone-Corsi P (1993): Induction of CREM activator proteins in spermatids: down-stream targets and implications for haploid germ cell differentiation. Mol Endocrinol 7: 1502–1514

    PubMed  CAS  Google Scholar 

  • Deutsch PJ, Hoeffler JP, Jameson JL, Habener JF (1988): Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci USA 85: 7922–7926

    PubMed  CAS  Google Scholar 

  • Flint KJ, Jones NC (1991): Differential regulation of three members of the ATF/CREB family of DNA-binding proteins. Oncogene 6: 2019–2026

    PubMed  CAS  Google Scholar 

  • Foulkes NS, Sassone-Corsi P (1992): More is better: activators and repressors from the same gene. Cell 68: 411–414

    PubMed  CAS  Google Scholar 

  • Foulkes NS, Borrelli E, Sassone-Corsi P (1991a): CREM gene: use of alternative DNA binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64: 739–749

    PubMed  CAS  Google Scholar 

  • Foulkes NS, Laoide BM, Schlotter F, Sassone-Corsi P (1991b): Transcriptional antagonist CREM down-regulates c-fos cAMP-induced expression. Proc Natl Acad Sci USA 88: 5448–5452

    PubMed  CAS  Google Scholar 

  • Foulkes NS, Mellström B, Benusiglio E, Sassone-Corsi P (1992): Developmental switch of CREM function during spermatogenesis: from antagonist to transcriptional activator. Nature 355: 80–84

    PubMed  CAS  Google Scholar 

  • Foulkes NS, Schlotter F, PĂ©vet P, Sassone-Corsi P (1993): Pituitary hormone FSH directs the CREM functional switch during spermatogenesis. Nature 362: 264–267

    PubMed  CAS  Google Scholar 

  • Gilman AG (1987): G Proteins: transducers of receptor-generated signals. Ann Rev Blochem 86: 615–649

    Google Scholar 

  • Ginty DD, GĹ‚owacka D, Bader DS, Hidaka H, Wagner JA (1991): Induction of immediate early genes by Ca2 + influx requires cAMP-dependent protein kinase in PC12 cells. J Biol Chem 266: 17454–17458

    PubMed  CAS  Google Scholar 

  • Gonzalez GA, Montminy MR (1989): Cyclic AMP stimulates somatostain gene transcription by phosphorylation of CREB at ser 133. Cell 59: 675–680

    PubMed  CAS  Google Scholar 

  • Gonzalez GA, Menzel P, Leonard J, Fischer WH, Montminy MR (1991): Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol Cell Biol 11: 1306–1312

    PubMed  CAS  Google Scholar 

  • Gonzalez GA, Yamamoto KK, Fischer WH, Karr K, Menzel P, Briggs III W, Vale WW, Montminy MR (1989): A cluster of phosphorylation sites on the cAMP-regulated nuclear factor CREB predicted by its sequence. Nature 337: 749–752

    PubMed  CAS  Google Scholar 

  • Grootegoed JA, Oonk RB, Toebosch AMW, Jansen R (1986): Extracellular factors that contribute to the development of spermatogenic cells. In: Molecular and Cellular Endocrinology of the Testis, Stefanini M, Conti M, Geremia R, Ziparo E, eds. Amsterdam: Excerpta Medica

    Google Scholar 

  • Habener J (1990): Cyclic AMP response element binding proteins: a cornucopia of transcription factors. Mol Endocrinol 4: 1087–1094

    PubMed  CAS  Google Scholar 

  • Hagiwara M, Alberts A, Brindle P, Meinkoth J, Feramisco J, Deng T, Karin M, Shenolikar S, Montminy M (1992): Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 70: 105–113

    PubMed  CAS  Google Scholar 

  • Hai T-Y, Liu F, Coukos WJ, Green MR (1989): Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA binding heterodimers. Genes Dev 3: 2083–2090

    PubMed  CAS  Google Scholar 

  • Heidaran MA, Kozak CA, Kistler WS (1989): Nucleotide sequence of the Stp-1 gene coding for rat spermatid nuclear transition protein 1 (TP1): homology with protamine PI and assignment of the mouse Stp-1 gene to chromosome 1. Gene 75: 39–46

    PubMed  CAS  Google Scholar 

  • Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (1988): Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242: 1430–1433

    PubMed  CAS  Google Scholar 

  • Hummler E, Cole TJ, Blendy JA, Ganss R, Aguzzi A, Schmid W, Beerman F, SchĂĽtz G (1994): Targeted mutation of the CREB gene: Compensation within the CREB/ATF Family of transcription factors. Proc Natl Acad Sci 91: 5647–5651

    PubMed  CAS  Google Scholar 

  • Illnervoa H, Vanecek J, Wetterberg L, Sääf JJ (1979): Effect of one minute exposure to light at night on rat pineal serotonin N-acetyltransferase and melatonin. Neurochem 32: 673

    Google Scholar 

  • JĂ©gou B, Syed V, Sourdaine P, Byers S, GĂ©rard N, Velez de la Calle J, Pineau C, Garnier DH, BauchĂ© F (1992): The dialogue between late spermatids and Sertoli cells in vertebrates: a century of research. In: Spermatogenesis. Fertilization. Contraception. Molecular, Cellular and Endocrine Events in Male Reproduction, Nieschlag E, Habenicht U-F, eds. New York: Springer Verlag.

    Google Scholar 

  • Johnson P, Peschon JJ, Yelick PC, Palmiter RD, Hecht NB (1988): Sequence homologies in the mouse protamine 1 and 2 genes. Biochim Biophys Acta 950: 45–53

    PubMed  CAS  Google Scholar 

  • Klein DC (1985): Photoneural regulation of the mammalial pineal gland. In: Photoperiodism, Melatonin and the Pineal Gland, London: Pitman

    Google Scholar 

  • Kramer IJM, Koornneef I, de Laat SW, van den Eijnden-van Raaij AJM (1991): TFG-β1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CCL64 cells. EM BO J 10: 1083–1089

    CAS  Google Scholar 

  • Krebs EG, Beavo JA (1979): Phosphorylation-dephosphorylation of enzymes. Ann Rev Biochem 48: 923–959

    PubMed  CAS  Google Scholar 

  • Landschulz WH, Johnson PF, McKnight SL (1988): The leucine-zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240: 1759–1764

    PubMed  CAS  Google Scholar 

  • Laoide BM, Foulkes NF, Schlotter F, Sassone-Corsi P (1993): The functional versatility of CREM is determined by its modular structure. EM BO J 12: 1179–1191

    CAS  Google Scholar 

  • Lee CQ, Yun Y, Hoeffler JP, Habener JF (1990): Cyclic-AMP-responsive transcriptional activation involves interdependent phosphorylated subdomains. EMBO J 9: 4455–4465

    PubMed  CAS  Google Scholar 

  • Leff S E, Rosenfeld M G, Evans R M (1986): Complex transcriptional units: diversity in gene expression by alternative RNA processing. Ann Rev Biochem 55: 1091–1117

    PubMed  CAS  Google Scholar 

  • Leonard J, Serup P, Gonzalez G, Edlund T, Montminy M (1992): The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. Proc Natl Acad Sci USA 89: 6247–6251

    PubMed  CAS  Google Scholar 

  • Lewin B (1991): Oncogenic conversion by regulatory changes in transcription factors. Cell 64: 303–312

    PubMed  CAS  Google Scholar 

  • Lin SC, Morrison-Bogorad M (1991): Cloning and characterization of a testis-specific thymosin β 10 cDNA. J Biol Chem 266: 23347–23353

    PubMed  CAS  Google Scholar 

  • Lonnerberg P, Parvinen M, Jahnsen T, Hansson V, Persson H (1992): Stage- and cell-specific expression of cyclic adenosine 3′, 5′-monophosphate-dependent protein kinases in rat seminiferous epithelium. Biol Reprod 46: 1057–1068

    PubMed  CAS  Google Scholar 

  • Lostroh AJ (1976): Hormonal control of spermatogenesis. In: Regulation Mechanisms of Male Reproductive Physiology, Spilman CH, Lobl TJ, Kirton KT, eds. Amsterdam: Excerpta Medica

    Google Scholar 

  • Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M, Ishii S (1989): Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J 8: 2023–2028

    PubMed  CAS  Google Scholar 

  • Masquilier D, Sassone-Corsi P (1992): Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun. J Biol Chem 267: 22460–22466

    PubMed  CAS  Google Scholar 

  • Masquilier D, Foulkes NS, Mattei MG, Sassone-Corsi P (1993): Human CREM gene: Evolutionary conservation, chromosomal localization, and inducibility of the transcript. Cell Growth & Differentiation 4: 931–937

    CAS  Google Scholar 

  • McCormick A, Brady H, Theill L, Karin M (1990): Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues. Nature 345: 829–832

    PubMed  CAS  Google Scholar 

  • McKnight SG, Clegg CH, Uhler MD, Chrivia JC, Cadd GG, Correll LA, Otten AD (1988): Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches. Rec Progr Horm Res 44: 307–335

    PubMed  CAS  Google Scholar 

  • Meijer GH (1991): In: Suprachiasmatic Nucleus/The Mind’s Clock, Klein DC, Moore RY, Reppert SM, eds. Oxford: Oxford University Press

    Google Scholar 

  • Mellon PL, Clegg CH, Correll LA, McKnight SG (1989): Regulation of transcription by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci USA 86:4887–4891

    PubMed  CAS  Google Scholar 

  • Mellström B, Naranjo JR, Foulkes NS, Lafarga M, Sassone-Corsi P (1993): Transcriptional response to cAMP in brain: specific distribution and induction of CREM antagonists. Neuron 10: 655–665

    PubMed  Google Scholar 

  • Meyer TE, Weaber G, Lin J, Beckman W, Habener JF (1993): The promoter of the gene encoding 3′, 5′-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive auto-regulation of gene transcription. Endocrinology 132: 770

    PubMed  CAS  Google Scholar 

  • Mizuki N, Sarapata DE, Garcia-Sanz JA, Kasahara M (1992): The mouse male germ cell-specific gene Tpx-1: molecular structure, mode of expression in spermatogenesis, and sequence similarity to two non-mammalian genes. Mammalian Genome 3: 274–280

    PubMed  CAS  Google Scholar 

  • Molina CA, Foulkes NS, Lalli E, Sassone-Corsi, P (1993): Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, and early response repressor. Cell 75: 875–886

    PubMed  CAS  Google Scholar 

  • Montmayeur JP, Borrelli E (1991): Transcription mediated by a cAMP-responsive promoter element is reduced upon activation of dopamine D2 receptors. Proc Natl Acad Sci USA 88: 3135–3139

    PubMed  CAS  Google Scholar 

  • Moore RY (1978): Neuroendocrine regulation of reproduction. In: Reproductive Endocrinology, Yen SSC, Jaffe RB, eds. Philadelphia: Sanders

    Google Scholar 

  • Morgan JI, Cohen DR, Hempstead JL, Curran T (1987): Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237: 192–197

    PubMed  CAS  Google Scholar 

  • Nathans D, Lau LF, Christy B, Hartzell S, Nakabeppu Y, Ryder K (1988): Genomic response to growth factors. Cold Spring Harbor Symp Quant Biol 53: 893

    PubMed  CAS  Google Scholar 

  • Nichols M, Weih F, Schmid W, DeVack C, Kowenz-Leutz E, Luckow B, Boshart M, SchĂĽtz G (1992): Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription. EM BO J 11: 3337–3346

    CAS  Google Scholar 

  • Nishizuka Y (1986): Studies and perspectives of protein kinase C. Science 233: 305–312

    PubMed  CAS  Google Scholar 

  • Oakberg J (1956): Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. Am J Anat 99: 504–516

    Google Scholar 

  • Oyen O, Scott JD, Cadd GG, McKnight GS, Krebs EB, Hansson V, Jahnsen T (1988): A unique mRNA species for a regulatory subunit of cAMP-dependent protein kinase is specifically induced in haploid germ cells. FEBS Lett 229: 391–394

    PubMed  CAS  Google Scholar 

  • Oyen O, Myklebust F, Scott JD, Cadd GG, McKnight SG, Hansson V, Jahnsen T (1990): Subunits of cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase show differential and distinct expression patterns during germ cell differentiation: alternative polyadenylation in germ cells gives rise to unique smaller-sized mRNA species. Biol Reprod 43: 46–54

    PubMed  CAS  Google Scholar 

  • Pariset C, Feinberg J, Dacheux JL, Oyen O, Jahnsen T, Weinman S (1989): Differential expression and subcellular localization for subunits of cAMP-dependent protein kinase during ram spermatogenesis. J Cell Biol 109: 1195–1205

    PubMed  CAS  Google Scholar 

  • Perlow MJ, Reppert SM, Tamarkin L, Wyatt RJ, Klein DC (1980): Photic regulation of the melatonin rhythm: monkey and man are not the same. Brain Res 182: 211 Rehfuss RP, Walton KM, Loriaux MM, Goodman RH (1991): The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J Biol Chem 266: 18431–18434

    Google Scholar 

  • Reiter RJ (1991): Pineal gland. Interface between the photoperiodic environment and the endocrine system. Trends Endocr Met 1:13

    Google Scholar 

  • Roesler WJ, Vanderbark GR, Hanson RW (1988): Cyclic AMP and the induction of eukaryotic gene expression. J Biol Chem 263: 9063–9066

    PubMed  CAS  Google Scholar 

  • Ruppert S, Cole TJ, Boshart M, Schmid E, Schu\dtz G (1992): Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J 11: 1503–1512

    PubMed  CAS  Google Scholar 

  • Russell LD (1980): Sertoli-germ cell interrelations: a review. Gamete Res 3: 179–202

    Google Scholar 

  • Sagar SM, Sharp FR, Curran T (1988): Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 240: 1328–1331

    PubMed  CAS  Google Scholar 

  • Santen RJ (1987): The testis. In: Endocrinology and Metabolism, Felig P, Baxter JD, Broadus AE, Frohman LA, eds. New York: McGraw-Hill

    Google Scholar 

  • Sassone-Corsi P (1988): Cyclic AMP induction of early adenovirus promoters involves sequences required for ElA-transactivation. Proc Natl Acad Sci USA 85: 7192–7196

    PubMed  CAS  Google Scholar 

  • Sassone-Corsi P, Ransone LJ, Verma IM (1990): Cross-talk in signal transduction: TPA-inducible factor Jun/AP-1 activates cAMP responsive enhancer elements. Oncogene 5: 427–431

    PubMed  CAS  Google Scholar 

  • Sassone-Corsi P, Visvader J, Ferland L, Mellon PL, Verma IM (1988): Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element. Genes Dev 2: 1529–1538

    PubMed  CAS  Google Scholar 

  • Sharp FR, Sagar SM, Hicks K, Lowenstein D, Hisanaga K (1991): c-fos mRNA, Fos and Fos-related antigen induction by hypertonic saline and stress. J Neurosci 11: 2321–2331

    PubMed  CAS  Google Scholar 

  • Shaw G, Kamen R (1986): A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659–667

    PubMed  CAS  Google Scholar 

  • Sheng M, McFadden G, Greenberg ME (1990): Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron 4: 571–582

    PubMed  CAS  Google Scholar 

  • Sheng M, Thompson MA, Greenberg ME (1991): CREB: a Ca2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252: 1427–1430

    PubMed  CAS  Google Scholar 

  • Sherman TG, McKelvy JF, Watson S J (1986): Vasopressin mRNA regulation in individual hypothalamic nuclei: a northern and in situ hybridization analysis. J Neurosci 6: 1685–1694

    PubMed  CAS  Google Scholar 

  • Stehle JH, Foules NS, Molina CA, Simonneaux V, PĂ©vet P, Sassone-Corsi P (1993): Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature 365: 314–320

    PubMed  CAS  Google Scholar 

  • Steinberger E (1971): Hormonal control of mammalian spermatogenesis. Physiol Rev 51: 1–22

    CAS  Google Scholar 

  • Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR (1991): Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350: 622–624

    PubMed  CAS  Google Scholar 

  • Sudgen D, Vanecek J, Klein DC, Thomas TD (1985): Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes. Nature 314: 359

    Google Scholar 

  • Takahashi JS (1993): Circadian clocks Ă  la CREM Nature 365: 299

    PubMed  CAS  Google Scholar 

  • Tamarkin L, Reppert SM, Klein DC (1979): Regulation of pineal melatonin in the Syrian hamster. Endocrinology 104: 385

    PubMed  CAS  Google Scholar 

  • Tamarkin L, Baird CJ, Almeida OFX (1985): Melatonin: a coordinating signal for mammalian reproduction? Science 227: 774

    Google Scholar 

  • van der Hoorn FA, Tarnasky HA (1992): Factors involved in regulation of the RT7 promoter in a male germ cell-derived in vitro transcription system. Proc Natl Acad Sci USA 89: 703–707

    PubMed  Google Scholar 

  • Vanecek J, Sudgen D, Weiler J, Klein DC (1985): Atypical synergistic al and β-adrenergic regulation of adenosine 3′,5′-Endocrinology 116: 2167

    Google Scholar 

  • Veldhuis JD (1991): The hypothalamic-pituitary-testicular axis. In: Reproductive Endocrinology Yen SSC, Jaffe RB, eds. Philadelphia: W.B. Saunders

    Google Scholar 

  • Verma IM, Sassone-Corsi P (1987): Proto-oncogene fos: complex but versatile regulation. Cell 51: 513–514

    PubMed  CAS  Google Scholar 

  • Vinson CR, Sigler P, McKnight SL (1989): Scissor-grip model for DNA recognition by a family of leucine zipper proteins. Science 246: 911–922

    PubMed  CAS  Google Scholar 

  • Waeber G, Meyer TE, LeSieur M, Hermann HL, GĂ©rard N, Habener JF (1991): Developmental stage-specific expression of cyclic adenosine 3′,5′-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol Endocrinol 5: 1418–1430

    PubMed  CAS  Google Scholar 

  • Williams T, Admon A, Luscher B, Tjian R (1988): Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Devi: 1557–1569

    Google Scholar 

  • Yamamoto KK, Gonzales GA, Briggs III WH, Montminy MR (1988): Phosphorylation-induced binding and transcriptional efficiency of nuclear factor CREB. Nature 334: 494–498

    PubMed  CAS  Google Scholar 

  • Yoshimasa T, Sibley DR, Bouvier M, Lefkowitz RJ, Caron MG (1987): Cross-talk between cellular signalling pathways suggested by phorbol ester adenylate cyclase phosphorylation. Nature 327: 67–70

    PubMed  CAS  Google Scholar 

  • Ziff EB (1990): Transcription factors: a new family gathers at the cAMP response site. Trends Genet 6: 69–72

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Janet S. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Enzo Lalli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Denis Masquilier
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Florence Schlotter
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carlos A. Molina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nicholas S. Foulkes
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Paolo Sassone-Corsi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Biochemistry, Albert-Ludwigs-University Freiburg, Hermann-Herder-Str. 7, D-79104, Freiburg i.Br., Germany

    P. A. Baeuerle

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Birkhäuser Boston

About this chapter

Cite this chapter

Lee, J.S. et al. (1995). CREM, a master-switch in the nuclear response to cAMP signaling. In: Baeuerle, P.A. (eds) Inducible Gene Expression, Volume 2. Progress in Gene Expression. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6837-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-6837-3_1

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6839-7

  • Online ISBN: 978-1-4684-6837-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation