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In Vivo Gene Transfer into the Heart

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Gene Therapeutics

Abstract

The expression of recombinant genes in the human coronary arteries and myocardium holds promise for the treatment of a number of inherited and acquired cardiovascular diseases. These include the cardiomyopathy associated with Duchenne Muscular Dystrophy (DMD) (For review, Perloff, 1992), the problem of restenosis following balloon angioplasty of the coronary arteries (For review, Safian et al., 1992) and syndromes of chronic myocardial ischemia (For review, Rutherford and Braunwald, 1992). Current approaches to somatic gene therapy can be divided into two general categories: Ex vivo gene transfer involves the removal of cells from an organism followed by gene transduction in vitro and reimplantation of the genetically modified cells into the appropriate tissue in vivo. In contrast, in vivo gene transfer involves the introduction of a recombinant gene into the appropriate cell type in vivo without the need to remove and culture cells from the recipient organism.

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Authors
  1. Jeffrey M. Leiden
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  2. Eliav Barr
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, University of Wisconsin Medical School, Waisman Center, Room 607 1500 Highland Avenue, Madison, WI, 53705-2208, USA

    Jon A. Wolff

  2. Department of Medical Genetics, University of Wisconsin Medical School, Waisman Center, Room 607 1500 Highland Avenue, Madison, WI, 53705-2208, USA

    Jon A. Wolff

  3. Department of Neurology, University of Wisconsin Medical School, Waisman Center, Room 607 1500 Highland Avenue, Madison, WI, 53705-2208, USA

    Jon A. Wolff

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© 1994 Birkhäuser Boston

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Leiden, J.M., Barr, E. (1994). In Vivo Gene Transfer into the Heart. In: Wolff, J.A. (eds) Gene Therapeutics. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6822-9_20

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  • DOI: https://doi.org/10.1007/978-1-4684-6822-9_20

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6824-3

  • Online ISBN: 978-1-4684-6822-9

  • eBook Packages: Springer Book Archive

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