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Sources of Discovery in Neuroscience

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The Neurosciences: Paths of Discovery, I
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Abstract

Frank Schmitt has been associated with so many aspects of research on the nervous system that it may be appropriate to do honour to him by trying to look at what has been discovered in neuroscience over the last forty years. This is a vast and indeed impossible task, and I shall make it even larger by trying to examine the general framework within which our science has grown. What have we been trying to do as we researched into the nervous system? What motives led each of us to study this part of the body? Is our work an academic exercise (whatever that may be), or is it to be thought of as an aid to humanity, say in medicine or education? What determines the methods that we use? Clearly the social milieu has an influence on each of us. Are we then slaves of bourgeois capitalism, or marxist or maoist socialism, or of some other ism? Does the system we belong to influence the research that we do?

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References

  • Adey, W. R. (1969): Slow electrical phenomena in the central nervous system. Neurosci. Res. Program Bull 7:75–180.

    Google Scholar 

  • Adrian, E. D. (1914): The all-or-none principle in nerve. J. Physiol 47:460–474.

    PubMed  CAS  Google Scholar 

  • Adrian, E. D., and Bronk, D. W. (1928): The discharge of impulses in motor nerve fibres. Part I. Impulses in single fibres of the phrenic nerve. J. Physiol 66:81–101.

    PubMed  CAS  Google Scholar 

  • Aitken, J. T., Sharman, M., and Young, J. Z. (1947): Maturation of regenerating nerve fibres with various peripheral connexions. J. Anat 81:1–22.

    Article  Google Scholar 

  • Anlezark, G. M., Crow, T. J., and Greenway, A. P. (1973): Evidence that the noradrenergic innervation of the cerebral cortex is necessary for learning. J. Physiol 231:119P–120P.

    PubMed  CAS  Google Scholar 

  • Bear, R. S., Schmitt, F. O., and Young, J. Z. (1937a): The sheath components of the giant nerve fibres of the squid. Proc. R. Soc. B 123:496–504.

    Article  CAS  Google Scholar 

  • Bear, R. S., Schmitt, F. O., and Young, J. Z. (1937b): The ultrastructure of nerve axoplasm. Proc. R.Soc.B 123:505–519.

    Article  CAS  Google Scholar 

  • Bear, R. S., Schmitt, F. O., and Young, J. Z. (1937c): Investigations on the protein constituents of nerve axoplasm. Proc. R. Soc. B 123:520–529.

    Article  CAS  Google Scholar 

  • Bernard, C. (1878–1879): Leçons sur les PhĂ©nomènes de la Vie Communs aux Animaux et aux VĂ©qĂ©taux (Cours de Physiologie GĂ©nĂ©rale du MusĂ©um d’Historie Naturelle). Vol. I and II. Paris: Ballière.

    Google Scholar 

  • Blakemore, C. (1974): Developmental factors in the formation of feature extracting neurons. In: The Neurosciences: Third Study Program Schmitt, F. O., and Worden, F. G., eds. Cambridge, Mass.: The MIT Press, pp. 105–113.

    Google Scholar 

  • Bliss, T. V. P., and Gardner-Medwin, A. R. (1973): Long-lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path. J. Physiol 232:357–374.

    PubMed  CAS  Google Scholar 

  • Bloom, F. E., Iversen, L. L., and Schmitt, F. O. (1970): Macromolecules in synaptic function. Neurosci. Res. Program Bull 8:325–455.

    PubMed  CAS  Google Scholar 

  • Boycott, B. B., and Young, J. Z. (1957): Effects of interference with the vertical lobe on visual discriminations in Octopus vulgaris Lamarck. Proc. R. Soc. B 146:439–459.

    Article  CAS  Google Scholar 

  • Braitenberg, V. (1967): Is the cerebellar cortex a biological clock in the millisecond range? Prog. Brain Res 25:334–346.

    Article  PubMed  CAS  Google Scholar 

  • Bullock, T. H. (1948): Properties of a single synapse in the stellate ganglion of squid. J. Neurophysiol 11:343–364.

    PubMed  CAS  Google Scholar 

  • Cannon, W. B. (1932): The Wisdom of the Body New York: W. W. Norton.

    Google Scholar 

  • Cole, K. S. (1968): Membranes, Ions and Impulses. A Chapter of Classical Biophysics Berkeley: University of California Press.

    Google Scholar 

  • Cole, K. S., and Curtis, H.J. (1936): Electric impedance of nerve and muscle. Cold Spring Harbor Symp. Quant. Biol 4:73–89.

    Article  Google Scholar 

  • Creed, R. S., Denny-Brown, D., Eccles, J. C., Liddell, E. G. T., and Sherrington, C. S. (1932): Reflex Activity of the Spinal Cord London: Oxford University Press.

    Google Scholar 

  • Dale, H. H. (1953): Acetylcholine as a chemical transmitter of the effects of nerve impulses. In: Adventures in Physiology. With Excursions into Autopharmacology London: Pergamon Press, pp. 611–637.

    Google Scholar 

  • Denny-Brown, D. (1966): The Cerebral Control of Movement (The Sherrington Lectures VIII). Liverpool, Eng.: Liverpool University Press.

    Google Scholar 

  • Dowling, J. E. (1970): Organization of vertebrate retinas. The Jonas M. Friedenwald Memorial Lecture. Invest. Ophthalmol 9:655–680.

    PubMed  CAS  Google Scholar 

  • Eccles, J. C. (1953): The Neurophysiological Basis of Mind. The Principles of Neurophysiology Oxford: Clarendon Press.

    Google Scholar 

  • Eccles, J. C., Granit, R., and Young, J. Z. (1932): Impulses in the giant nerve fibres of earthworms. J. Physiol 77:23P–25P.

    Google Scholar 

  • Erlanger, J., and Gasser, H. S. (1937): Electrical Signs of Nervous Activity Philadelphia: University of Pennsylvania Press.

    Google Scholar 

  • Evarts, E. V. (1968): Relation of pyramidal tract activity to force exerted during voluntary movement. J. Neurophysiol 31:14–27.

    PubMed  CAS  Google Scholar 

  • Evarts, E. V., Bizzi, E., Burke, R. E., De Long, M., and Thach, W. T., Jr. (1971): Central control of movement. Neurosci. Res. Program Bull 9:2–170.

    Google Scholar 

  • Forbes, A. (1922): The interpretation of spinal reflexes in terms of present knowledge of nerve conduction. Physiol. Rev 2:361–414.

    Google Scholar 

  • Gaffan, D. (1972): Loss of recognition memory in rats with lesions of the fornix. Neuropsychologia 10:327–341.

    Article  PubMed  CAS  Google Scholar 

  • Gaffan, D. (1973): Inhibitory gradients and behavioural contrast in rats with lesions of the fornix. Physiol. Behav 11:215–220.

    Article  PubMed  CAS  Google Scholar 

  • Gaze, R. M. (1970): The Formation of Nerve Connections. A Consideration of Neural Specificity Modulation and Comparable Phenomena New York: Academic Press.

    Google Scholar 

  • Gaze, R. M., Keating, M. J., and Chung, S. H. (1974): The evolution of the retinotectal map during development in Xenopus. Proc. R. Soc. B 185:301–330.

    Article  CAS  Google Scholar 

  • Gerard, R. W., and Young, J. Z. (1937): Electrical activity of the central nervous system of the frog. Proc. R. Soc. B 122:343–352.

    Article  Google Scholar 

  • Geren, B. B. (1954): The formation from the Schwann cell surface of myelin in the peripheral nerves of chick embryos. Exp. Cell Res 7:558–562.

    Article  Google Scholar 

  • Granit, R. (1972): Mechanisms Regulating the Discharge of Motoneurons (The Sherrington Lectures XI). Springfield, Ill.: C. C Thomas.

    Google Scholar 

  • Gray, E. G., and Young, J. Z. (1968): The electron microscopy of experimental degeneration in the octopus brain. In: Cell Structure and Its Interpretation. Essays Presented to John Randal Baker F. R. S McGee-Russell, S. M., and Ross, K. F. A., eds. London: Edward Arnold, pp. 371–380.

    Google Scholar 

  • Gross, C. G., Rocha-Miranda, C. E., and Bender, D. B. (1972): Visual properties of neurons in inferotemporal cortex of the macaque. J. Neurophysiol 35:96–111.

    PubMed  CAS  Google Scholar 

  • Hebb, D. O. (1949): The Organization of Behavior. A Neuropsychological Theory New York: John Wiley.

    Google Scholar 

  • Henderson, L.J. (1913): The Fitness of the Environment. An Inquiry into the Biological Significance of the Properties of Matter New York: Crowell-Collier and MacMillan.

    Google Scholar 

  • Hess, W. R. (1956): Hypothalamus and Thalamus. Experimental Documentation Stuttgart: Georg Thieme Verlag.

    Google Scholar 

  • Hobbs, M.J., and Young, J. Z. (1973): A cephalopod cerebellum. Brain Res 55:424–430.

    Article  PubMed  CAS  Google Scholar 

  • Hodgkin, A. L. (1954): A note on conduction velocity. J. Physiol 125:221–224.

    PubMed  CAS  Google Scholar 

  • Hodgkin, A. L., and Huxley, A. F. (1952): A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol, 117:500–544.

    PubMed  CAS  Google Scholar 

  • Horridge, G. A. (1962): Learning of leg position by the ventral nerve cord in headless insects. Proc. R. Soc. B 157:33–52.

    Article  Google Scholar 

  • Horridge, G. A. (1973): Summary. In: Australian Academy of Science Report: Symposium on Biological Memory

    Google Scholar 

  • Hoyle, G. (1970): Cellular mechanisms underlying behavior—neuroethology. Adv. Insect Physiol 7:349–444.

    Article  Google Scholar 

  • Hubel, D. H., and Wiesel, T. N. (1959): Receptive fields of single neurones in the cat’s striate cortex. J. Physiol 148:574–591.

    PubMed  CAS  Google Scholar 

  • Jameson, F. (1972): The Prison-House of Language: A Critical Account of Structuralism and Russian Formalism (Princeton Essays in European and Comparative Literature). Princeton, N.J.: Princeton University Press.

    Google Scholar 

  • John, E. R. (1967): Mechanisms of Memory New York: Academic Press.

    Google Scholar 

  • Kandel, E. R., and Kupfermann, I. (1970): The functional organization of invertebrate ganglia. Annu. Rev. Physiol 32:193–258.

    Article  PubMed  CAS  Google Scholar 

  • Katz, B. (1966): Nerve, Muscle and Synapse New York: McGraw-Hill.

    Google Scholar 

  • Kennedy, D., Selverston, A. I., and Remler, M. P. (1969): Analysis of restricted neural networks. Science 164:1488–1496.

    Article  PubMed  CAS  Google Scholar 

  • Kerkut, G. A. (1969): The use of snail neurons in neurophysiological studies. Endeavour 28:22–26.

    PubMed  CAS  Google Scholar 

  • Kuhn, T. S. (1962): The Structure of Scientific Revolutions Chicago: University of Chicago Press.

    Google Scholar 

  • Kuntz, A. (1934): The Autonomic Nervous System Philadelphia: Lea and Febiger.

    Google Scholar 

  • Langley, J. N. (1903): The autonomic nervous system. Brain 26:1–26.

    Article  Google Scholar 

  • Lettvin, J. Y., Maturana, H. R., McCulloch, W. S., and Pitts, W. H. (1959): What the frog’s eye tells the frog’s brain. Proc. IRE 47:1940–1951.

    Article  Google Scholar 

  • Lopresti, V., Macagno, E. R., and Levinthal, C. (1973): Structure and development of neuronal connections in isogenic organisms: cellular interactions in the development of the optic lamina of Daphnia. Proc. Natl. Acad. Sci. USA 70:433–437.

    Article  CAS  Google Scholar 

  • Lorente de NĂł, R. (1938): Analysis of the activity of the chains of internuncial neurons. J. Neurophysiol 1:207–244.

    Google Scholar 

  • Lucas, K. (1909): The “all or none” contraction of the amphibian skeletal muscle fibre. J. Physiol 38:113–133.

    PubMed  CAS  Google Scholar 

  • Lucas, K. (1912): Croonian Lecture: The process of excitation in nerve and muscle. Proc. R. Soc. B 85:495–524.

    Article  Google Scholar 

  • Mark, R. (1973): Cellular mechanisms of neural memory. In: Australian Academy of Science Report: Symposium on Biological Memory

    Google Scholar 

  • Miledi, R. (1967): Spontaneous synaptic potentials and quantal release of transmitter in the stellate ganglion of the squid. J. Physiol 192:379–406.

    PubMed  CAS  Google Scholar 

  • Mokrasch, L. C., Bear, R. S., and Schmitt, F. O. (1971): Myelin. Neurosci. Res. Program Bull 9:440–598.

    Google Scholar 

  • Mountcastle, V. B. (1957): Modality and topographic properties of single neurons of cat’s somatic sensory cortex. J. Neurophysiol 20:408–434.

    PubMed  CAS  Google Scholar 

  • MĂĽller, J. (1848): The Physiology of the Senses, Voice, and Muscular Motion, with the Mental Facilities Baly, W., trans. London: Taylor, Walton and Maberly.

    Google Scholar 

  • Nishioka, R. S., Hagadorn, I. R., and Bern, H. A. (1962): Ultrastructure of the epistellar body of the Octopus. Z. Zellforsch. Mikrosk. Anat 57:406–421.

    Article  PubMed  CAS  Google Scholar 

  • Offner, F., Weinberg, A., and Young, G. (1940): Nerve conduction theory: Some mathematical consequences of Bernstein’s model. Bull. Math. Biophys 2:89–103.

    Article  Google Scholar 

  • O’Keefe, J., and Dostrovsky, J. (1971): The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34:171–175.

    Article  PubMed  Google Scholar 

  • Papez, J. W. (1937): A proposed mechanism of emotion. Arch. Neurol. Psychiatr 38:725–743.

    Google Scholar 

  • Pavlov, I. P. (1927): Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex Anrep, G. V., trans, and ed. Oxford: Oxford University Press.

    Google Scholar 

  • Pettigrew, J. D. (1974): The effect of visual experience on the development of stimulus specificity by kitten cortical neurones. J. Physiol 237:49–74.

    PubMed  CAS  Google Scholar 

  • Popper, K. R. (1972): Objective Knowledge: An Evolutionary Approach Oxford: Clarendon Press.

    Google Scholar 

  • Pumphrey, R. J., and Young, J. Z. (1938): The rates of conduction of nerve fibres of various diameters in cephalopods. J. Exp. Biol 15:453–466.

    Google Scholar 

  • Ritter, S., and Stein, L. (1973): Self-stimulation of noradrenergic cell group (A6) in Locus coeruleus of rats. J. Comp. Physiol. Psychol. 85:443–452.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, J. D. (1955): The ultrastructure of adult vertebrate peripheral myelinated nerve fibers in relation to myelinogenesis. J. Biophys. Biochem. Cytol 1:271–278.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, J. D. (1965): The synapse: Morphological and chemical correlates of function. Neurosci. Res. Program Bull 3(4): 1–79.

    Google Scholar 

  • Rushton, W. A. H. (1951): A theory of the effects of fibre size in medullated nerve. J. Physiol 115:101–122.

    PubMed  CAS  Google Scholar 

  • Sanders, G. D., and Young, J. Z. (1974): Reappearance of specific colour patterns after nerve regeneration in Octopus. Proc. R. Soc. B 186:1–11.

    Article  CAS  Google Scholar 

  • Saussure, F. de (1916): Cours de Linguistique GĂ©nĂ©rale Paris: Payot.

    Google Scholar 

  • Schmitt, F. O. (1967): Molecular parameters in brain function. In: The Human Mind Roslansky, J. D., ed. Amsterdam: North-Holland, pp. 109–138.

    Google Scholar 

  • Schmitt, F. O., and Samson, F. E., Jr. (1969): Brain cell microenvironment. Neurosci. Res. Program Bull 7: 277–417.

    Google Scholar 

  • Sherrington, G. S. (1906): The Integrative Action of the Nervous System New York: Scribner.

    Google Scholar 

  • Sjöstrand, F. S. (1953): The lamellated structure of the nerve myelin sheath as revealed by high resolution electron microscopy. Experientia 9:68–69.

    Article  PubMed  Google Scholar 

  • Spencer, W. A., and Kandel, E. R. (1961): Electrophysiology of hippocampal neurons. IV. Fast prepotentials. J. Neurophysiol 24:272–285.

    Google Scholar 

  • Sperry, R. W. (1944): Optic nerve regeneration with return of vision in anurans. J. Neurophysiol 7:57–69.

    Google Scholar 

  • Sperry, R.W. (1950): Neural basis of the spontaneous optokinetic response, J. Comp, Physiol. Psychol 4:482–489.

    Article  Google Scholar 

  • Stephens, R. (1974): Electrophysiological studies of the brain of Octopus vulgaris. J. Physiol 240:19 pp.

    Google Scholar 

  • Tauc, L. (1967): Transmission in invertebrate and vertebrate ganglia. Physiol. Rev 47:521–593.

    PubMed  CAS  Google Scholar 

  • Ungerstedt, U. (1971): Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol. Scand 367 (Suppl.):l–48.

    Google Scholar 

  • Von Holst, E. (1973): The Selected Papers of Eric von Holst Vol. 1. The Behavioural Physiology of Animals and Man Martin, R., trans. London: Methuen.

    Google Scholar 

  • Wall, P. D. (1965): Functional specificity. Neurosci. Res. Program Bull 3:55–56,

    Google Scholar 

  • Wall, P. D. (1965): Functional specificity. Neurosci. Res. Program Bull 3:61. Also

    Google Scholar 

  • Wall, P. D. (1965): In: Neurosciences Research Symposium Summaries Vol. 1. Schmitt, F. O., et al., eds. Cambridge, Mass.: The MIT Press (1966) pp. 229–230,

    Google Scholar 

  • Wall, P. D. (1965): In: Neurosciences Research Symposium Summaries Vol. 1. Schmitt, F. O., et al., eds. Cambridge, Mass.: The MIT Press (1966) pp. 235.

    Google Scholar 

  • Warrington, E. K. (1971): Neurological disorders of memory. Br. Med. Bull 27:243–247.

    PubMed  CAS  Google Scholar 

  • Waxman, S. G. (1974): Ultrastructural differentiation of the axon membrane at synaptic and non-synaptic central nodes of Ranvier. Brain Res 65:338–342.

    Article  PubMed  CAS  Google Scholar 

  • Webb, D. A., and Young, J. Z. (1940): Electrolyte content and action potential of the giant nerve fibres of Loligo. J. Physiol 98:299–313.

    PubMed  CAS  Google Scholar 

  • Wells, M.J. (1965): The vertical lobe and touch learning in the octopus. J. Exp. Biol 42:233–255.

    PubMed  CAS  Google Scholar 

  • Wiener, N. (1948): Cybernetics, or Control and Communication in the Animal and the Machine Cambridge, Mass.: The MIT Press.

    Google Scholar 

  • Wiersma, C. A. G. (1952): The neuron soma. Neurons of arthropods. Cold Spring Harbor Symp. Quant. Biol 17:155–163.

    Article  PubMed  CAS  Google Scholar 

  • Wiesel, T. N., and Hubel, D. H. (1963): Effects of visual deprivation on morphology and physiology of cells in the cat’s lateral geniculate body. J. Neurophysiol 26:978–993.

    PubMed  CAS  Google Scholar 

  • Wurtman, R. J. (1971): Brain monoamines and endocrine function. Neurosci. Res. Program Bull 9:172–297.

    Google Scholar 

  • Young, J. Z. (1929): Sopra un nuovo organo dei cefalopodi. Boll. Soc. Ital. Biol. Sper 4:1022–1024.

    Google Scholar 

  • Young, J. Z. (1936a): The giant nerve fibres and epistellar body of cephalopods. Q.. J. Microsc. Sci 78:367–386.

    Google Scholar 

  • Young, J. Z. (1936b): Structure of nerve fibres and synapses in some invertebrates. Cold Spring Harbor Symp. Quant. Biol 4:1–6.

    Article  CAS  Google Scholar 

  • Young, J. Z. (1938a): The evolution of the nervous system and of the relationship of organism and environment. In: Evolution. Essays on Aspects of Evolutionary Biology Presented to Prof. E. S. Goodrich on his 70th Birthday De Beer, G. R., ed. Oxford: Clarendon Press, pp. 179–204.

    Google Scholar 

  • Young, J. Z. (1938b): The functioning of the giant nerve fibres of the squid. J. Exp. Biol 15:170–185.

    Google Scholar 

  • Young, J. Z. (1944): Giant nerve-fibres. Endeavour 3:108–113.

    Google Scholar 

  • Young, J. Z. (1964): A Model of the Brain Oxford: Clarendon Press.

    Google Scholar 

  • Young, J. Z. (1965): The Croonian Lecture, 1965: The organization of a memory system. Proc. R. Soc. B 163:285–320.

    Article  CAS  Google Scholar 

  • Young, J. Z. (1973): Memory as a selective process. In: Australian Academy of Science Report: Symposium on Biological Memory, pp. 25–45.

    Google Scholar 

  • Young, J. Z. (1974): The central nervous system of Loligo I. The optic lobe. Phil. Trans. R. Soc. B. 267:263–302.

    Article  PubMed  CAS  Google Scholar 

  • Young, T. (1802): The Bakerian Lecture: On the theory of light and colours. Phil. Trans. R. Soc. B. 95:12–48.

    Google Scholar 

  • Zeki, S. M. (1973): Colour coding in rhesus monkey prestriate cortex. Brain Res. 53:422–427.

    Article  PubMed  CAS  Google Scholar 

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Frederic G. Worden Judith P. Swazey George Adelman

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Young, J.Z. (1992). Sources of Discovery in Neuroscience. In: Worden, F.G., Swazey, J.P., Adelman, G. (eds) The Neurosciences: Paths of Discovery, I. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6817-5_2

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