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The Role of Free Fatty Acids in CTL-Target Cell Interactions

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Book cover Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods

Abstract

Fatty acids (FA) are critical to the maintenance of physiological homeostasis. They are the major source of energy, provide essential building blocks of membrane structure, and play a variety of modulatory functions either as FA themselves or as precursors of hormone-like molecules. An immunomodulatory role for dietary FA has long been the subject of investigation (see, e.g., Meade and Mertin, 1978; Cave, 1991). A variety of in vivo and in vitro studies involving long-term exposure to FA have obtained evidence suggesting both inhibition and stimulation of cytolytic T lymphocyte (CTL) activity by cis-unsaturated FA treatment (Meade and Mertin, 1976; Bialick et al., 1984).

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Authors
  1. Alan M. Kleinfeld
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Editors and Affiliations

  1. Laboratory of Immunology, Biochemistry and Immunopharmacology Unit, NIH-NIAID, 20892, Bethesda, Maryland, USA

    Michail V. Sitkovsky

  2. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA

    Pierre A. Henkart

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© 1993 Birkhäuser Boston

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Kleinfeld, A.M. (1993). The Role of Free Fatty Acids in CTL-Target Cell Interactions. In: Sitkovsky, M.V., Henkart, P.A. (eds) Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6814-4_30

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  • DOI: https://doi.org/10.1007/978-1-4684-6814-4_30

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6816-8

  • Online ISBN: 978-1-4684-6814-4

  • eBook Packages: Springer Book Archive

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