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Transcriptional Control of Pituitary Gene Expression

  • Chapter
Gene Expression

Part of the book series: Progress in Gene Expression ((PRGE))

Abstract

Cascades of interacting regulatory genes controlling developmental pathways have been defined in organisms such as Drosophila (Chalfie and Au, 1989; Cohen and Jurgens, 1991; Gehring, 1987; Ingham, 1988; Ingham and Martinez Arias, 1992; Moses, 1991; Nusslein-Volhard and Wieschaus 1980; Nusslein-Volhard et al., 1987; Perkins and Perrimon, 1991; St. Johnston and Nusslein-Volhard, 1992) and the nematode Caenorhabditis elegans (Davidson, 1990; Sternberg and Horvitz, 1991). The developmental regulators include transcription factors, kinases, phosphatases, growth factors, receptors, and cell-adhesion molecules. In Drosophila, products of maternally expressed genes control expression of zygotic segmentation genes, the products of which regulate homeotic gene expression; regulation is also exerted between genes of the same class. As a result the embryo is divided into a meshwork of metameric units, each expressing a unique combination of homeotic genes. These genes contain a conserved homeobox, encoding a 60-amino-acid home-odomain that functions in DNA binding. By acting as transcription factors, the homeodomain proteins orchestrate activation of a unique combination of target genes that causes the cells to enter a specific morphogenetic pathway.

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Authors
  1. Lars Eyde Theill
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  1. Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA

    Michael Karin

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© 1993 Birkhäuser Boston

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Theill, L.E. (1993). Transcriptional Control of Pituitary Gene Expression. In: Karin, M. (eds) Gene Expression. Progress in Gene Expression. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6811-3_8

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  • DOI: https://doi.org/10.1007/978-1-4684-6811-3_8

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6813-7

  • Online ISBN: 978-1-4684-6811-3

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