Membrane-Derived Lipid Second Messengers as Targets for Neuroprotection: Platelet-Activating Factor

  • Nicolas G. Bazan
  • Jacques M. Cluzel
Part of the Advances in Neuroprotection book series (AN, volume 22)


Platelet-activating factor [PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine); also called AGEPC or PAF acether] is an ether phospholipid implicated in several human pathologies including asthma and shock, cardiac and systemic anaphylaxis, immune and renal disorders, and a variety of inflammatory conditions (Braquet et al., 1987; Prescott et al., 1990). In addition, several lines of evidence suggest the implication of PAF in various pathophysiologic processes of the central nervous system (CNS). Indeed, several PAF receptor antagonists have been used successfully to limit brain damage in animal models of ischemia (Panetta et al., 1987; Spinnewyn et al., 1987; Birkle et al., 1988; Kochanek et al., 1987; Szabo et al., 1991), stroke (Lindsberg et al., 1990), and experimental allergic encephalomyelitis (Howat et al., 1989). Recent evidence shows a role for PAF in the release of excitatory amino acid neurotransmitters (Clark et al., 1991) and in long-term potentiation (Del Cerro et al., 1990).


Electroconvulsive Shock Remodel Pathway Excitatory Amino Acid Neurotransmitter 
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© Birkhäuser Boston 1992

Authors and Affiliations

  • Nicolas G. Bazan
  • Jacques M. Cluzel

There are no affiliations available

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