Lazaroids: Novel Cerebroprotective Antioxidants

  • Edward D. Hall
Part of the Advances in Neuroprotection book series (AN, volume 22)


Considerable biochemical, physiologic, and pharmacologic evidence supports the occurrence and importance of oxygen free radical-induced lipid peroxidation in the acute pathophysiology of central nervous system (CNS) injury and ischemia (i.e., stroke) (Braughler and Hall, 1989; Hall and Braughler, 1989). The 21-aminosteroids, or “lazaroids,” are a novel series of compounds being developed for the acute treatment of traumatic or ischemic CNS injury that have been specifically designed to localize within cell membranes and inhibit lipid peroxidation reactions.


Spinal Cord Injury Global Cerebral Ischemia Methylprednisolone Sodium Succinate Postischemic Brain Bilateral Carotid Occlusion 
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Copyright information

© Birkhäuser Boston 1992

Authors and Affiliations

  • Edward D. Hall

There are no affiliations available

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