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Emerging Strategies in Neuroprotection pp 224–237Cite as

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Lazaroids: Novel Cerebroprotective Antioxidants

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Part of the book series: Advances in Neuroprotection ((AN,volume 22))

Abstract

Considerable biochemical, physiologic, and pharmacologic evidence supports the occurrence and importance of oxygen free radical-induced lipid peroxidation in the acute pathophysiology of central nervous system (CNS) injury and ischemia (i.e., stroke) (Braughler and Hall, 1989; Hall and Braughler, 1989). The 21-aminosteroids, or “lazaroids,” are a novel series of compounds being developed for the acute treatment of traumatic or ischemic CNS injury that have been specifically designed to localize within cell membranes and inhibit lipid peroxidation reactions.

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Authors
  1. Edward D. Hall
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Editors and Affiliations

  1. NeuroTherapeutics Corp. and Center for Neurologic Study, 11211 Sorrento Valley Road, 92121, San Diego, CA, USA

    Paul J. Marangos

  2. Department of Pharmacology, Texas College of Osteopathic Medicine, 3500 Camp Bowie Boulevard, 76107, Fort Worth, TX, USA

    Harbans Lal

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© 1992 Birkhäuser Boston

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Hall, E.D. (1992). Lazaroids: Novel Cerebroprotective Antioxidants. In: Marangos, P.J., Lal, H. (eds) Emerging Strategies in Neuroprotection. Advances in Neuroprotection, vol 22. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4684-6796-3_11

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  • DOI: https://doi.org/10.1007/978-1-4684-6796-3_11

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  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4684-6798-7

  • Online ISBN: 978-1-4684-6796-3

  • eBook Packages: Springer Book Archive

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