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The 5-HT1A Receptor: From Molecular Characteristics to Clinical Correlates

  • Chapter
Book cover Molecular Biology of G-Protein-Coupled Receptors

Part of the book series: Applications of Molecular Genetics to Pharmacology ((AMGP))

Abstract

The past decade has seen a remarkable growth in our understanding of the pharmacology and physiology of the various receptors for serotonin (5-hydroxytryptamine, 5-HT). Since 1979, when radioligand binding techniques were used to distinguish subtypes of 5-HT binding sites (Peroutka and Snyder, 1979), no less than ten subtypes of 5-HT receptors have been characterized (Richardson and Engel, 1986; Bradley et al., 1986; Mawe et al., 1986; Heuring and Peroutka, 1987; Dumuis et al., 1988b; Leonhardt et al., 1989; Conner and Monsour, 1990). However, the biochemical characterization of these receptors has been hampered by the lack of selective radioligands and/or cell lines expressing single well-characterized receptor subtypes.

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Authors
  1. John R. Raymond
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  2. Salah El Mestikawy
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  3. Annick Fargin
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  1. Molecular Neuropharmacology Section Department of Psychiatry College of Medicine, University of Vermont, 05405-0068, Burlington, VT, USA

    Mark R. Brann

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Raymond, J.R., El Mestikawy, S., Fargin, A. (1992). The 5-HT1A Receptor: From Molecular Characteristics to Clinical Correlates. In: Brann, M.R. (eds) Molecular Biology of G-Protein-Coupled Receptors. Applications of Molecular Genetics to Pharmacology. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6772-7_5

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  • DOI: https://doi.org/10.1007/978-1-4684-6772-7_5

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