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Molecular Biology of G-Protein-Coupled Receptors pp 31–61Cite as

Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins

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Part of the book series: Applications of Molecular Genetics to Pharmacology ((AMGP))

Abstract

A remarkably diverse array of biologically active substances elicit their actions by interacting with Cell surface receptors which are coupled via guanine nucleotide regulatory proteins (G-proteins) to specific biochemical effectors. Examples include neurotransmitters, hormones, many drugs, and even sensory stimuli such as light and odorants. Perhaps the most thoroughly studied example of such a receptor system is the β2-adrenergic receptor for catecholamines which mediates stimulation of adenylyl cyclase via Gs. Within the past few years its primary structure has become known via molecular cloning, and substantial progress has also been made in learning how its unique structural features determine such specific functions as ligand binding and G-protein activation. Much has also been learned about the mechanisms by which its function is regulated. Moreover, a great deal of this information appears to be generally applicable to the other members of the broad family of G-protein-coupled receptors. This chapter reviews some of the most important information developed over the past several years.

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  1. Brian O’Dowd
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  2. Sheila Collins
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  3. Michel Bouvier
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  4. Marc G. Caron
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  5. Robert J. Lefkowitz
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  1. Molecular Neuropharmacology Section Department of Psychiatry College of Medicine, University of Vermont, 05405-0068, Burlington, VT, USA

    Mark R. Brann

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O’Dowd, B., Collins, S., Bouvier, M., Caron, M.G., Lefkowitz, R.J. (1992). Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins. In: Brann, M.R. (eds) Molecular Biology of G-Protein-Coupled Receptors. Applications of Molecular Genetics to Pharmacology. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6772-7_2

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  • DOI: https://doi.org/10.1007/978-1-4684-6772-7_2

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