Abstract
Scientists have debated the mechanisms responsible for the “epileptic” behavior of single neurons since their electrical responses during experimental seizures were first described (Matsumoto and Ajmone Marsan, 1964a, b). These sometimes spirited discussions were based, appropriately, upon the known mechanisms for neuronal excitability and synaptic transmission. But, even the elegant axon model of Hodgkin and Huxley (1952) and the mechanisms for synaptic transmission identified by Eccles and his colleagues (Eccles, 1964) could not always explain the individual cellular responses or the synchronization observed in experimental epilepsy. It was not until this decade that such techniques as ion selective electrodes, in vitro brain slices, tissue culture, and patch recording provided us with new ideas about cellular and synaptic processes in the central nervous system. With these new findings, neurobiologists no longer had difficulty formulating rational and testable hypotheses about mechanisms underlying many aspects of seizure generation.
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Crill, W.E., Schwindt, P.C., Spain, W.J. (1990). Membrane Properties of Cat Betz Cells Studied In Vitro. In: Avoli, M., Gloor, P., Kostopoulos, G., Naquet, R. (eds) Generalized Epilepsy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6767-3_5
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DOI: https://doi.org/10.1007/978-1-4684-6767-3_5
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