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Anhedonia as an Animal Model of Depression

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Animal Models of Depression

Abstract

The clinical syndrome of depression is characterized by significant and long-term changes in mood and cognitive function. One of the most salient symptoms of a major depressive episode is a failure to obtain pleasure from activities that previously brought enjoyment (Klein, 1974). Recreational activities, sex, and eating now provide little or no gratification. The mood of the individual is characterized as depressed, sad, hopeless, and discouraged.

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Authors
  1. George F. Koob
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Editors and Affiliations

  1. Department of Neuropharmacology, Research Institute of the Scripps Clinic, La Jolla, CA, 92037, USA

    George F. Koob PhD  & Cindy L. Ehlers PhD  & 

  2. Department of Psychiatry, University of Pittsburgh Medical School, 3811 O’Hara Street, Pittsburgh, PA, 15261, USA

    David J. Kupfer M.D. (Professor and Chairman) (Professor and Chairman)

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Koob, G.F. (1989). Anhedonia as an Animal Model of Depression. In: Koob, G.F., Ehlers, C.L., Kupfer, D.J. (eds) Animal Models of Depression. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6762-8_9

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  • DOI: https://doi.org/10.1007/978-1-4684-6762-8_9

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6764-2

  • Online ISBN: 978-1-4684-6762-8

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