Skip to main content

Pharmacological Probes in Primate Social Behavior

  • Chapter
Animal Models of Depression

Abstract

The appropriateness of interaction with other individuals constitutes a significant factor in the determination of the diagnosis and treatment response in major psychiatric categories. Therefore, animal models of these disorders which include evaluation of social behavior add an important dimension to the model. Non-human primates have been used as subjects in most social studies because of their well documented social structure and noted behavioral similarities to humans.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Angrist BM, Sathananian G, Wilk S, Gershon S (1974): Amphetamine psychosis: Behavioral and biochemical aspects. J Psychiatr Res 11:13–23

    Article  PubMed  CAS  Google Scholar 

  • Bellarosa A, Bedford J, Wilson MC (1980): Sociopharmacology of d-Amphetamine in Macaca arctoides. Pharmacol Biochem Behav 13:221–228

    Article  CAS  Google Scholar 

  • Boelkins RC (1979): Effects of parachlorophenylalanine on the behavior of monkeys. In: Serotonin and Behavior, Barchas J, Usdin E, eds. New York: Academic Press

    Google Scholar 

  • Burki HR, Eichenberger E, Sayers AC (1975): Clozapine and the dopamine hypothesis of schizophrenia: A critical appraisal. Pharmakopsychiatr Neuropsychopharmakol 8:115–121

    PubMed  CAS  Google Scholar 

  • Connell PH (1958): Amphetamine psychosis. Maudsley Monographs No.5. London Oxford University

    Google Scholar 

  • Crowley TJ, Stynes AJ, Hydinger M, Kaufmann IC (1974): Ethanol, metham-phetamine, pentobarbital, morphine, and monkey social behavior. Arch Gen Psychiatry 31:829–838

    Article  PubMed  CAS  Google Scholar 

  • Crowley TJ, Stynes AJ, Hydinger M, Feiger A (1975): Monkey motor stimulation and altered social behavior during chronic methadone administration. Psychopharmacology 43:135–144

    Article  CAS  Google Scholar 

  • Dubach MF, Bowden DM (1983): Response to intracerebral dopamine injection as a model of schizophrenic symptomatology. In: Ethopharmacohgy: Primate Models of Neuropsychiatric Disorders, Miczek KA, ed. New York: Alan R. Liss

    Google Scholar 

  • Fabre-Nys C, Meller RE, Keverne EB (1982): Opiate antagonists stimulate affiliative behaviour in monkeys. Pharmacol Biochem Behav 16:653–659

    Article  PubMed  CAS  Google Scholar 

  • Freis ED (1954): Mental depression in hypertensive patients treated for long periods with large doses of reserpine. New Engl J Med 251:1006

    Article  PubMed  CAS  Google Scholar 

  • Garver DL, Schlemmer RF, Jr, Maas JW, Davis JM (1975): A schizophreniform behavioral psychosis mediated by dopamine. Am J Psychiatry 132:33–38

    PubMed  CAS  Google Scholar 

  • Gold MS, Donabedian RK, Redmond DE Jr (1979): Further evidence for alpha2-adrenergic receptor mediated inhibition of prolactin secretion: The effect of yohimbine. Psychoneuroendocrinology 3:253–260

    Article  Google Scholar 

  • Haber S, Berger PA, Barchas PR (1979): The effects of amphetamine on agonistic behaviors in nonhuman primates. In: Catecholamines: Bask and Clinical Frontiers, Usdin E, Kopin IJ, Barchas J, eds. New York: Pergamon Press

    Google Scholar 

  • Kalin NH (1985): Behavioral effects of ovine corticotropin-releasing factor administered to rhesus monkeys. Fed Proc 44:249–253

    PubMed  CAS  Google Scholar 

  • Kjellberg B, Randrup A (1973): Disruption of social behavior of vervet monkeys (Cercopithecus) by low doses of amphetamines. Pharmakopsychiatria 6:287–293

    Article  CAS  Google Scholar 

  • Kornetsky C (1977): Animal models: Promises and problems. In: Animal Models in Psychiatry and Neurology, Hanin I, Usdin E, eds. Oxford: Pergamon Press

    Google Scholar 

  • Kraemer GW, Ebert MH, Lake CR, McKinney WT (1983): Amphetamine challenge: Effects in previously isolated rhesus monkeys and implications for animal models of schizophrenia. In: Ethopharmacology: Primate Models of Neuropsychiatrie Disorders, Miczek KA, ed. New York: Alan R. Liss

    Google Scholar 

  • Kraemer GW, McKinney WT (1979): Interactions of pharmacological agents which alter biogenic amine metabolism and depression. J Affective Disord 1:33–54

    Article  CAS  Google Scholar 

  • Machiyama Y, Utena H, Kikuchi M (1970): Behavioural disorders in Japanese monkeys produced by the long-term administration of methamphetamine. Proc Japan Acad 46:738–743

    Google Scholar 

  • McKinney WT Jr (1974): Primate social isolation. Arch Gen Psychiatr 31:422–426

    Article  PubMed  Google Scholar 

  • McKinney WT Jr, Eising RG, Moran EC, Suomi SJ, Harlow JF (1971): Effects of reserpine on the social behavior of rhesus monkeys. Dis Nerv Syst 32:735–741

    PubMed  CAS  Google Scholar 

  • Meiler RE, Keverne EB, Herbert J (1980): Behavioural and endocrine effects of naltrexone in male talapoin monkeys. Pharmacol Biochem Behav 13:663–672

    Article  Google Scholar 

  • Miczek KA (1983): Ethopharmacology: Primate Models of Neuropsychiatrie Disorders. New York: Alan R. Liss

    Google Scholar 

  • Miczek KA, Woolley J, Schlisserman S, Yoshimura H (1981): Analysis of amphetamine effects on agonistic and affiliative behavior in squirrel monkeys (Saimari sciureus). Pharmacol Biochem Behav 14:103–107

    CAS  Google Scholar 

  • Miczek KA, Yoshimura J (1982): Disruption of primate social behavior by d-amphetamine and cocaine: Differential antagonism by antipsychotics. Psychopharmacology 76:163–171

    Article  PubMed  CAS  Google Scholar 

  • Miller MH, Geiger E (1976): Dose effects of amphetamine on macaque social behavior: Reversal by haloperidol. Res Commun Psychol Psychiat Behav 1:125–142

    Google Scholar 

  • Miller RE, Levine JM, Mirsky IA (1973): Effects of psychoactive drugs on nonverbal communication and group behavior in monkeys. J Person Soc Psychol 28:396–405

    Article  CAS  Google Scholar 

  • New JS, Yevich JP, Temple DL, Jr, New KB, Gross SM, Schlemmer RF Jr, Eison MS, Taylor DP, Riblett LA (1988): Atypical antipsychotic agents: Patterns of activity in a series of 3-substituted-2-pyridinyl-1-piperazine derivatives. J Med Chem 31:618–624

    Article  PubMed  CAS  Google Scholar 

  • Nielsen EB, Eison MS, Lyon M, Iversen SD (1983): Hallucinatory behaviors in primates produced by around-the-clock amphetamine treatment for several days via implanted capsules. In: Ethopharmacology: Primate Models of Neuropsychiatric Disorders, Miczek KA, ed. New York: Alan R. Liss

    Google Scholar 

  • Peroutka SJ, Snyder SH (1980): Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry 137:1518–1522

    PubMed  CAS  Google Scholar 

  • Poignant JC, Avril A (1978): Pharmacological studies on drug acting on the social behavior of the squirrel monkeys. Arzneimittelforsch 28:267–271

    PubMed  CAS  Google Scholar 

  • Raleigh MJ, Brammer GL, McGuire MT (1983): Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (Cercopithecus aethiops sabaeus). In: Ethopharmacology: Primate Models of Neuropsychiatric Disorders, Miczek KA, ed. New York: Alan R. Liss

    Google Scholar 

  • Raleigh MJ, Brammer GL, McGuire MT, Yuwiler A (1985): Dominant social status facilitates the behavioral effects of serotonergic agonists. Brain Res 348:274–282

    Article  PubMed  CAS  Google Scholar 

  • Raleigh MJ, Brammer GL, Yuwiler A, Flannery JW, McGuire MT, Geller E (1980): Serotonergic influences on the social behavior of vervet monkeys (Cercopithecus aethiops sabaeus). Exp Neurol 68:322–334

    Article  PubMed  CAS  Google Scholar 

  • Raleigh MJ, Buwiler A, Brammer GL, McGuire MT, Geller E, Flannery JW (1981): Peripheral correlates of serotonergically-influenced behaviors in vervet monkeys (Cercopithecus aethiops sabaeus). Psychopharmacology 72:241–246

    Article  PubMed  CAS  Google Scholar 

  • Redmond DE Jr, Hinrichs RL, Mass JW, Kling A (1973): Behavior of free-ranging macaques after intraventricular 6-hydroxydopamine. Science 181:1256–1258

    Article  PubMed  CAS  Google Scholar 

  • Redmond DE, Jr, Maas JW, Kling A, Dekirmenjian H (1971a): Changes in primate social behavior after treatment with alpha-methyl-paratyrosine. Psychosom Med 33:97–113

    PubMed  CAS  Google Scholar 

  • Redmond DE, Jr, Maas JW, Kling A, Graham CW, Dekirmenjian H (1971b): Social behavior of monkeys selectively depleted of monoamines. Science 174:428–431

    Article  PubMed  CAS  Google Scholar 

  • Ridley RM, Baker HF (1983): Is there a relationship between social isolation, cognitive inflexibility, and behavioral stereotype? An analysis of the effects of amphetamine in the marmoset. In: Ethopharmacology: Primate Models of Neuropsychiatrie Disorders, Miczek KA, ed. New York: Alan R. Liss

    Google Scholar 

  • Schiorring E (1977): Changes in individual and social behavior induced by amphetamine and related compounds in monkeys and man. In: Cocaine and Other Stimulants, Ellinwood EH, ed. New York: Plenum Press

    Google Scholar 

  • Schlemmer RF Jr, Casper RC, Narasimhachari N, Davis JM (1979): Clonidine-induced hyperphagia and weight gain in monkeys. Psychopharmacology 61:233–234

    Article  PubMed  Google Scholar 

  • Schlemmer RF Jr, Casper RC, Elder JK, Davis JM (1981): Hyperphagia and weight gain in monkeys treated with Clonidine. In: Psychopharmacology of Clonidine, Lal H, Fielding S, eds. New York: Alan R. Liss

    Google Scholar 

  • Schlemmer RF, Jr, Davis JM (1981b): Evidence for dopamine mediation of submissive gestures in the stumptail macaque monkey. Pharmacol Biochem Behav 14(Suppl. 1):95–102

    PubMed  CAS  Google Scholar 

  • Schlemmer RF, Jr, Davis JM (1981a): Similarities in the behavioral effects of d-amphetamine and apomorphine in selected members of a primate social colony. In: Recent Advances in Neuropsychopharmacology, Advances in the Bio-Sciences, vol. 31, Angrist B, Burrows GD, Lader M, Lingjaedre O, Sedvall G, Wheatley D, eds. Oxford: Pergamon Press

    Google Scholar 

  • Schlemmer RF, Jr, Davis JM (1983): A comparison of three psychotomimeticinduced models of psychosis in nonhuman primate social colonies. In: Ethopharmacology: Primate Models of Neuropsychiatrie Disorders, Miczek KA, ed. New York: Alan R. Liss

    Google Scholar 

  • Schlemmer, RF Jr, Davis JM (1985): Antagonism of amphetamine-induced behavioral changes by BMY13859–1 in a primate model of psychosis. Neurosci Abst 11:114

    Google Scholar 

  • Schlemmer RF Jr, Davis JM (1986): A primate model for the study of hallucinogens. Pharmacol Biochem Behav 24:381–392

    Article  PubMed  CAS  Google Scholar 

  • Schlemmer RF Jr, Jackson JA, Preston KL, Bederka JP Jr., Garver DL, Davis JM (1978): Phencyclidine-induced stereotyped behavior in monkeys. Eur J Pharmacol 52:379–384

    Article  PubMed  CAS  Google Scholar 

  • Schlemmer RF Jr, Narasimahachari N, Davis JM (1980): Dose dependent behavioral changes induced by apomorphine in selected members of a primate social colony. J Pharm Pharmacol 32:285–289

    Article  PubMed  CAS  Google Scholar 

  • Scraggs PR, Baker HF, Ridley RM (1979): Interaction of apomorphine and haloperidol: Effects on locomotion and other behavior in the marmoset. Psychopharmacology 66:41–43

    Article  PubMed  CAS  Google Scholar 

  • Scraggs PR, Ridley RM (1979): The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Psychopharmacology 62: 41–45

    Article  PubMed  CAS  Google Scholar 

  • Sitaram N, Gershon S (1983): From animal models to clinical testing-promise and pitfalls. Prog Neuropsychopharmacol Biol Psychiatry 7:227–228

    Article  PubMed  CAS  Google Scholar 

  • Smith EO, Byrd LD (1983): Contrasting the effects of d-amphetamine on affiliation and aggression in monkeys. Pharmacol Biochem Behav 20:255–260

    Article  Google Scholar 

  • Snyder SH (1972): Catecholamines in the brain as mediators of amphetamine psychosis. Arch Gen Psychiatry 27:169–179

    Article  PubMed  CAS  Google Scholar 

  • Tennant FS Jr, Rawson RA (1983): Cocaine and amphetamine dependence treated with desipramine. In: Problems of Drug Dependence, 1982, NID A Research Monograph 43, Harris LS, ed. Rockville: PHS

    Google Scholar 

  • Wilson MC, Bailey L, Bedford JA (1983): Effects of subacute administration of amphetamine on food competition in primates. In: Ethopharmacobgy: Primate Models of Neuropsychiatrie Disorders, Miczek KA, ed. New York: Alan R. Liss

    Google Scholar 

  • Woolverton WL, Goldberg LI, Ginos JZ (1984): Intravenous self-administration of dopamine receptor agonists by rhesus monkeys. J Pharmacol Exp Ther 230:678–683

    PubMed  CAS  Google Scholar 

  • Young JE, Verlangieri AJ, Wilson MC (1986): The effects of Clonidine on food consumption and food competition in male stumptail macaques (Macaca arctoides). Pharmacol Biochem Behav 24:1567–1572

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Birkhäuser Boston

About this chapter

Cite this chapter

Schlemmer, R.F., Young, J.E., Davis, J.M. (1989). Pharmacological Probes in Primate Social Behavior. In: Koob, G.F., Ehlers, C.L., Kupfer, D.J. (eds) Animal Models of Depression. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6762-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-6762-8_12

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6764-2

  • Online ISBN: 978-1-4684-6762-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics