Abstract
Changes occur in the tensile strength of compacts produced from powdered Hydroxypropyl methylcellulose (HPMC) after storage at different relative humidities (S.Malamataris et al., Int. J. Pharm., 1994). Studies in this laboratory have noted that subjecting a hydrophilic matrix formulation of a Class I drug (Amidon et al., 1995) to accelerated stability conditions resulted in a reduction in tablet crushing strength. An in vitro dissolution method developed in this laboratory indicated that such physical changes in this hydrophilic matrix formulation could potentially result in an altered in vivo profile.
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© 1997 Plenum Press, New York
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Stark, P. et al. (1997). in Vivo-in Vitro Evaluation of the Impact of Accelerated Stability Conditions on a Hydrophilic Matrix Tablet. In: Young, D., Devane, J.G., Butler, J. (eds) In Vitro-in Vivo Correlations. Advances in Experimental Medicine and Biology, vol 423. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6036-0_21
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DOI: https://doi.org/10.1007/978-1-4684-6036-0_21
Publisher Name: Springer, Boston, MA
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