Abstract
A controlled release hydrophilic matrix tablet formulation of a Class I (Amidon et al., 1995) drug containing hydroxypropylmethylcellulose (HPMC) has been developed. The level of HPMC has previously been shown to influence the in vivo release of the drug from this formulation. However, a standard dissolution test utilising USP II aqueous methodology failed to discriminate sufficiently between formulations. Therefore, work was undertaken to develop a novel discriminatory dissolution method based on retrospective in vivo data.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Plenum Press, New York
About this chapter
Cite this chapter
Farrell, C., Butler, J., Stark, P., Madden, H., Devane, J. (1997). The Development of a Novel in Vitro Discriminatory Dissolution Method for a Class I Drug in a Matrix Tablet Formulation. In: Young, D., Devane, J.G., Butler, J. (eds) In Vitro-in Vivo Correlations. Advances in Experimental Medicine and Biology, vol 423. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6036-0_20
Download citation
DOI: https://doi.org/10.1007/978-1-4684-6036-0_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-6038-4
Online ISBN: 978-1-4684-6036-0
eBook Packages: Springer Book Archive