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Regulated Secretion in Vascular Endothelium

  • Chapter
Book cover Cell-Cell Interactions in the Release of Inflammatory Mediators

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 314))

Abstract

Eukaryotic cells secrete proteins through both regulated and constitutive pathways (1). In the regulated pathway, exocytosis of stored material is coupled to an external stimulus which produces transient elevations in [Ca2+]i, cAMP or other secondary messengers (2, 3). Secretion is ultimately accomplished by the translocation of the exocytotic granule to the subcortical regions of the cell and the fusion of the cellular plasma membrane with the membranes of the secretory organelle. The process of regulated secretion has at least two distinct consequences. First, the rapid release of the contents of the storage granule generates locally high concentrations of peptides, proteins and other bioactive compounds in the vicinity of the secretory cell. These products may promote cell-cell interaction through the activation of target cells or the crosslinking of surface receptors. Second, the translocation of secretory granule membrane proteins to the plasma membrane of the secretory cell may provide new or additional binding sites for cellular adhesion.

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Authors and Affiliations

  1. Division of Hematology and Medicine, Brigham & Women’s Hospital, Boston, MA, 02115, USA

    Bruce M. Ewenstein & Brian C. Jacobson

  2. Departments of Pathology, Harvard Medical School, Boston, MA, 02115, USA

    Kimberly A. Birch

Authors
  1. Bruce M. Ewenstein
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  2. Brian C. Jacobson
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  3. Kimberly A. Birch
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Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Patrick Y.-K. Wong

  2. Harvard Medical School, Boston, Massachusetts, USA

    Charles N. Serhan

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© 1991 Plenum Press, New York

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Ewenstein, B.M., Jacobson, B.C., Birch, K.A. (1991). Regulated Secretion in Vascular Endothelium. In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_9

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  • DOI: https://doi.org/10.1007/978-1-4684-6024-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6026-1

  • Online ISBN: 978-1-4684-6024-7

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