Hepoxilins Modulate Second Messenger Systems in the Human Neutrophil

  • Cecil R. Pace-Asciak
  • Santosh Nigam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 314)


In this chapter, we will review recent findings which implicate the hepoxilins as modulators of second messenger systems in the human neutrophil. We have shown that the hepoxilins affect calcium homeostasis in the cell and that they stimulate the release of arachidonic acid and diradylglycerol but not inositol phosphate indicating a mode of action for these 12-lipoxygenase metabolites that is independent of phospholipase C activation. In fact lipid analyses indicate that the phospholipid affected by the hepoxilins is phosphatidyl choline, and that this phospholipid is hydrolyzed by a phospholipase D. These findings indicate that the hepoxilins, which are formed by the platelet as well as the neutrophil, may affect neutrophil activation through a potential cell-cell interaction in the circulation or at pathologic sites to initiate or potentiate the inflammatory process.


Arachidonic Acid Phosphatidyl Choline Human Neutrophil Phosphatidic Acid Inositol Phosphate 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Cecil R. Pace-Asciak
    • 1
  • Santosh Nigam
    • 2
  1. 1.Research Institute, Hospital for Sick ChildrenTorontoCanada
  2. 2.Eicosanoid Research, Department of Gynaecological EndocrinologyFree University of BerlinGermany

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