Skip to main content

Red Cell-Neutrophil Interactions in the Regulation of Active Oxygen Species and Lipoxygenase Products

  • Chapter
Cell-Cell Interactions in the Release of Inflammatory Mediators

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 314))

Abstract

Recent evidence indicates that neutrophil eicosanoid metabolism is altered by the presence of another cell type. Possible mechanisms for effecting eicosanoid metabolism in neutrophils by other cell types are related to the capacity of these cell types to incorporate, deactivate or metabolize eicosanoids and their intermediates or provide or scavenge reactants that are utilized by neutrophils.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Weiss, S.J. The role of superoxide in the destruction of erythrocyte targets by human neutrophils. J. Biol. Chem. 255, 9912–9917, 1980.

    PubMed  CAS  Google Scholar 

  2. Test, S.T. and Weiss, S.J. Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils. J. Biol. Chem. 259, 399–405, 1984.

    PubMed  CAS  Google Scholar 

  3. Klebanoff, S.J. Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J. Bacteriol. 95, 2131–2138, 1968.

    PubMed  CAS  Google Scholar 

  4. Winterbourn, C.C. and Stern, A. Human red cells scavenge extracellular hydrogen peroxide and inhibit formation of hypochlorous acid and hydroxyl radical. J. Clin. Invest. 80, 1486–1491, 1987.

    Article  PubMed  CAS  Google Scholar 

  5. McGee, J.E. and Fitzpatrick, F.A. Erythrocyte-neutrophil interactions: Formation of leukotriene B4 by transcellular biosynthesis. Proc. Natl. Acad. Sci. USA. 83, 1349–1353, 1986.

    Article  PubMed  CAS  Google Scholar 

  6. Marcus, A.J., Weksler, B.B., Jaffe, E.A. and Broekman, M.J. Synthesis of prostacyclin from platelet-derived endoperoxides by cultured human endothelial cells. J. Clin. Invest. 66 979–986, 1980.

    Article  PubMed  CAS  Google Scholar 

  7. Fitzpatrick, F., Liggett, W., McGee, J., Bunting, S., Morton, D. and Samuelsson, B. Metabolism of leukotriene A4 by human erythrocytes. J. Biol. Chem. 259, 11403–11407, 1984.

    PubMed  CAS  Google Scholar 

  8. Orning, L., Jones, D.A. and Fitzpatrick, F.A. Mechanism-based inactivation of leukotriene A4 hydrolase during leukotriene B4 formation by human erythrocytes. J. Biol. Chem. 265, 14911–14916, 1990.

    PubMed  CAS  Google Scholar 

  9. Stern, A. and Serhan, C.N. Human red cells enhance formation of 5-lipoxygenase-derived products by neutrophils. Free Rad. Res. Comm. 7, 335–339, 1989.

    Article  CAS  Google Scholar 

  10. Boyum, A. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21, Suppl. 97, 77–89, 1967.

    Google Scholar 

  11. Serhan, C.N. On the relationship between leukotriene and lipoxin production by human neutrophils; evidence for differential metabolism of 15-HETE and 5-HETE. Biochim. Biophys. Acta. 1004, 158–168, 1989.

    PubMed  CAS  Google Scholar 

  12. Sullivan, S.G. and Stern, A. Effects of physiologic concentrations of lactate, pyruvate and ascorbate on glucose metabolism in unstressed and oxidatively stressed human red blood cells. Biochem. Pharmacol. 32, 2891–2902, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Romson, J.L., Hook, B.G., Kunkel, S.L. Abrams, G.D., Schork, M.A. and Lucchesi, B.R. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 67, 1016–1023, 1983.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Stern, A. (1991). Red Cell-Neutrophil Interactions in the Regulation of Active Oxygen Species and Lipoxygenase Products. In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-6024-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6026-1

  • Online ISBN: 978-1-4684-6024-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics