Keratinocytes Can Regulate Prostaglandin Synthesis by Fibroblasts: Potential Role for Interleukin 1
Skin can be considered as a two-compartment tissue consisting of an overlying epidermis and an underlying dermis separated by a selectively permeable basement membrane. Studies on the communication between these skin compartments have shown that the keratinocyte, which is the constitutive cell of the epidermis appears susceptible to modulation by dermally derived influences. In tissue recombinant experiments, Billingham and Silvers (1967) found that regional epidermal histomorphology in guinea pigs (e.g. sole versus ear) was determined by the origin of the dermal component. Melbye and Karasek (1973) and Mackenzie and Fusenig (1983) further found that facilitation of epidermal proliferation may depend on diffusable, dermally-derived factors.
KeywordsHuman Keratinocytes Prostaglandin Synthesis Human Dermal Fibroblast 3T3M Cell Keratinocyte Proliferation
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- Balavoine, J.-F., de Rochemonteix, B., Williamson, K., Seckinger, P., Cruchaud, A., and Dayer, J.-M., 1986, Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s), J. Clin. Invest. 78: 1120.PubMedCrossRefGoogle Scholar
- Goldyne, M.E., 1988, Human fibroblast and keratinocyte synthesis of eicosanoids in response to interleukin 1: Evidence for fibroblast heterogeneity, In: Endocrine, Metabolic and Immunologic Functions of Keratinocytes, (L.M. Milstone and R.L. Edelson, Eds.), Ann. N.Y. Acad. Sci., New York, 548: 108.Google Scholar
- Goldyne, M.E., and Rea, L., 1991, CHILD Syndrome: Altered prostaglandin synthesis in involved skin fibroblasts inhibits interleukin 1 alpha-dependent proliferation, submitted for publication.Google Scholar
- Hogquist, K., Katz, I., Chaplin, D., and Strunk, R., 1989, Developmental regulation of IL-1 in human fibroblast lines, J. Cell Biol. 107(6): 484a.Google Scholar
- Kupper, T.S., Ballard, D.W., Chua, A.O., McGuire, J., Flood, P.M., Horowitz, M.C., Langdon, R., Lightfoot, L., and Gubler, U., 1986, Human keratinocytes contain mRNA indistinguishable from monocyte interleukin la and ß mRNA: Keratinocyte epidermal cell derived thymocyte activating factor is identical to interleukin 1. J. Exp. Med. 164: 2095.PubMedCrossRefGoogle Scholar
- Libby,P., Ordovas, J. M., and Dinarello, C.A., 1986, Regulated expression by human vascular smooth muscle cells of a gene for the inflammatory mediator interleukin 1 (IL-1), Clin. Res. 34(2): 321A.Google Scholar
- O’Keefe, E.J., Dinarello, C.A., and Chiu, M.J., 1986, Keratinocyte growth-promoting activity from human placenta: Potentiation of thymocyte growth and distinction from IL-1, Clin. Res. 34(2): 772A.Google Scholar
- Rupp, E.A., Cameron, P.M., Ranawat, C.S., Schmidt, J.A., and Bayne, E.K., 1986, Specific bioactivities of monocyte-derived interleukin la and interleukin 1ß are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells, J. Clin. Invest. 78: 836.PubMedCrossRefGoogle Scholar