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The Role of Leukotriene A4 Hydrolase in Cells and Tissues Lacking 5-Lipoxygenase

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Cell-Cell Interactions in the Release of Inflammatory Mediators

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 314))

Abstract

Leukotriene (LT) A4 hydrolase converts the unstable epoxide intermediate LTA4 into the potent proinflammatory compound LTB4. The formation of LTA4 is catalyzed by the enzyme 5-lipoxygenase and involves the dioxygenation of arachidonic acid with subsequent epoxide formation (1).

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Authors and Affiliations

  1. Department of Physiological Chemistry II, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden

    Hans-Erik Claesson, Jesper Z. Haeggström, Björn Odlander, Juan F. Medina, Anders Wetterholm, Per-Johan Jakobsson & Olof Rådmark

Authors
  1. Hans-Erik Claesson
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  2. Jesper Z. Haeggström
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  3. Björn Odlander
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  4. Juan F. Medina
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  5. Anders Wetterholm
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  6. Per-Johan Jakobsson
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  7. Olof Rådmark
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Editor information

Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Patrick Y.-K. Wong

  2. Harvard Medical School, Boston, Massachusetts, USA

    Charles N. Serhan

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© 1991 Plenum Press, New York

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Claesson, HE. et al. (1991). The Role of Leukotriene A4 Hydrolase in Cells and Tissues Lacking 5-Lipoxygenase. In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_20

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  • DOI: https://doi.org/10.1007/978-1-4684-6024-7_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6026-1

  • Online ISBN: 978-1-4684-6024-7

  • eBook Packages: Springer Book Archive

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