The Role of Leukotriene A4 Hydrolase in Cells and Tissues Lacking 5-Lipoxygenase

  • Hans-Erik Claesson
  • Jesper Z. Haeggström
  • Björn Odlander
  • Juan F. Medina
  • Anders Wetterholm
  • Per-Johan Jakobsson
  • Olof Rådmark
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 314)


Leukotriene (LT) A4 hydrolase converts the unstable epoxide intermediate LTA4 into the potent proinflammatory compound LTB4. The formation of LTA4 is catalyzed by the enzyme 5-lipoxygenase and involves the dioxygenation of arachidonic acid with subsequent epoxide formation (1).


Calcium Ionophore Raji Cell Calcium Ionophore A23187 Zinc Binding Site LTA4 Hydrolase 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hans-Erik Claesson
    • 1
  • Jesper Z. Haeggström
    • 1
  • Björn Odlander
    • 1
  • Juan F. Medina
    • 1
  • Anders Wetterholm
    • 1
  • Per-Johan Jakobsson
    • 1
  • Olof Rådmark
    • 1
  1. 1.Department of Physiological Chemistry IIKarolinska InstitutetStockholmSweden

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