Metabolism of Granulocyte-Derived Leukotriene A4 in Human Platelets and Respiratory Tissue: Transcellular Formation of Lipoxins and Leukotrienes

  • Charlotte Edenius
  • Leif Stenke
  • Susanne Tornhamre
  • Katarina Heidvall
  • Inger Forsberg
  • Barbro Näsman-Glaser
  • Jan Åke Lindgren
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 314)


Leukotriene (LT)A4, the unstable intracellular intermediate in leukotriene biosynthesis, may be released to the extracellular space by activated leukocytes (1). As a consequence, the metabolism of LTA4 is not restricted to cells with 5-lipoxygenase activity, but can also be exerted by other cell types equipped with LTA4-metabolizing enzymes. Thus, LTA4, released by 5-lipoxygenase expressing cells, may be converted to LTB4 by surrounding erythrocytes (2), endothelial cells (3) or lymphocytes (4), all possessing LTA4 hydrolase activity. Similarly, mast cells (1), endothelial cells (3, 5) and smooth muscle cells (6) have been demonstrated to convert LTA4 to cysteinyl-containing leukotrienes. The present chapter describes some of our recent data regarding the metabolism of synthetic or granulocyte-derived LTA4 in human platelets and respiratory tissue leading to formation of cysteinyl-containing leukotrienes and lipoxins (LX).


Arachidonic Acid Chronic Myelogenous Leukemia Nasal Polyp Human Platelet Epoxide Hydrolase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Charlotte Edenius
    • 1
  • Leif Stenke
    • 1
  • Susanne Tornhamre
    • 1
  • Katarina Heidvall
    • 1
  • Inger Forsberg
    • 1
  • Barbro Näsman-Glaser
    • 1
  • Jan Åke Lindgren
    • 1
  1. 1.Department of Physiological ChemistryKarolinska InstitutetStockholmSweden

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