Abstract
The lipoxins constitute a new class of arachidonic acid derivatives which may be produced by for example leukocytes, or by leukocytes interacting with platelets (cf. Dahlén and Serhan 1990). The biosynthesis of lipoxins is the result of interactions between different lipoxygenases, and the lipoxins characteristically possess a conjugated tetraene structure (Serhan et al., 1984; cf. Dahlén and Serhan 1990). The two major compounds, lipoxin A4 and B4 (LXA4, 5S, 6R, 15S-trihydroxy-7, 9, 13-trans-ll-cis-eicosatetraenoic acid; LXB4, 5S,14R,15S-trihydroxy-6, 10, 12-trans-8-cis-eicosatetraenoic acid), display a number of biological actions, indicating their involvement as modulators of events such as intracellular signal transduction, immunological defence and inflammation (cf. Dahlén and Serhan 1990).
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© 1991 Plenum Press, New York
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Raud, J., Palmertz, U., Dahlén, SE., Hedqvist, P. (1991). Lipoxins Inhibit Microvascular Inflammatory Actions of Leukotriene B4 . In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_11
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DOI: https://doi.org/10.1007/978-1-4684-6024-7_11
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