Lipoxins Inhibit Microvascular Inflammatory Actions of Leukotriene B4

  • Johan Raud
  • Ulla Palmertz
  • Sven-Erik Dahlén
  • Per Hedqvist
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 314)


The lipoxins constitute a new class of arachidonic acid derivatives which may be produced by for example leukocytes, or by leukocytes interacting with platelets (cf. Dahlén and Serhan 1990). The biosynthesis of lipoxins is the result of interactions between different lipoxygenases, and the lipoxins characteristically possess a conjugated tetraene structure (Serhan et al., 1984; cf. Dahlén and Serhan 1990). The two major compounds, lipoxin A4 and B4 (LXA4, 5S, 6R, 15S-trihydroxy-7, 9, 13-trans-ll-cis-eicosatetraenoic acid; LXB4, 5S,14R,15S-trihydroxy-6, 10, 12-trans-8-cis-eicosatetraenoic acid), display a number of biological actions, indicating their involvement as modulators of events such as intracellular signal transduction, immunological defence and inflammation (cf. Dahlén and Serhan 1990).


Nedocromil Sodium Cheek Pouch Plasma Leakage Eicosatetraenoic Acid Hamster Cheek Pouch 
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  1. Björk, J., Goldschmidt, T., Smedegard, G., and Arfors, K.-E., 1985, Methylprednisolone acts at the endothelial cell level reducing inflammatory responses, Acta Physiol. Scand., 123: 221.PubMedCrossRefGoogle Scholar
  2. Björk, J., Hedqvist, P., and Arfors, K.-E., 1982, Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytes, Inflammation, 6: 189.PubMedCrossRefGoogle Scholar
  3. Björk, J., Smedegård, G., Svensjö, E., and Arfors, K.-E., 1984, The use of the hamster cheek pouch for intravital microscopy studies of microvascular events Prog, appl. Microcirc., 6: 41.Google Scholar
  4. Dahlén, S.-E., Björck, T., Kumlin, M., Sydbom, A., Raud, J., Palmertz, U., Franzén, L., Grönneberg, R., and Hedqvist P., 1989, Dual Inflammatory action of Nedocromil sodium on antigen-induced inflammation, Drugs, 37(Suppl. I): 63.PubMedCrossRefGoogle Scholar
  5. Dahlén, S.-E., Hansson, G., Hedqvist, P., Björck, T., Granström, E., and Dahlén, B., 1983, Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotriene C4, D4, and E4, Proc. Natl. Acad. Sci. USA, 80: 708.CrossRefGoogle Scholar
  6. Dahlén, S.-E., Raud, J., Serhan, C.N., Björk, J., and Samuelsson, B., 1987, Biological activities of Lipoxin A include lung strip contraction and dilation of arterioles in vivo, Acta Physiol. Scand., 130: 643.PubMedCrossRefGoogle Scholar
  7. Dahlén, S.-E. and Serhan, C.N., 1991, Lipoxins: Bioactive lipoxygenase interaction products, in: “Lipoxygenases in Inflammation,” A. Wong and S.T. Crooke, ed., Academic Press, San Diego, p. 235.Google Scholar
  8. Gorman, R.R., Oglesby, T.D., Bundy, G.L. and Hopkins, N.L., 1985, Evidence for 15-HETE synthesis by human umbilical vein endothelial cells, Circulation, 72: 708.PubMedCrossRefGoogle Scholar
  9. Hamberg, M., Hedqvist, P., and Rådegran, K., 1980, Identification of 15-hydroxy-5, 8, 11, 13-eicosatetraenoic acid (15-HETE) as a major metabolite of arachidonic acid in human lung, Acta Physiol. Scand., 110: 219.PubMedCrossRefGoogle Scholar
  10. Hansson, A., Serhan, C.N., Haeggström, J., Ingelman-Sundberg, B., Samuelsson, B., and Morris, J., 1986, Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid, Biochem. Biophys. Res. Commun., 134: 1215.PubMedCrossRefGoogle Scholar
  11. Hedqvist, P., Dahlén, S.-E., Raud, J., Lindbom, L., Thuresson-Klein, Å., and Nicolaou, K.C., 1989a, Aspects of eicosanoids in inflammation, in: “Prostanoids and Drugs,” B. Samuelsson, F. Berti, G.C. Folco, and G.P. Velo, ed., Plenum Press, New York, p. 169.Google Scholar
  12. Hedqvist, P., Raud, J., Palmertz, U., Haeggström, J., Nicolaou, K.C., and Dahlén, S.-E., 1989b, Lipoxin A4 inhibits leukotriene B4-induced inflammation in the hamster cheek pouch, Acta Physiol. Scand., 137: 571.PubMedCrossRefGoogle Scholar
  13. Hedqvist, P., Raud, J., and Dahlén, S.-E., 1990, Microvascular actions of eicosanoids in the hamster cheek pouch, Adv. Prostaglandin Thromboxane Leukotriene Res., 20: 153.Google Scholar
  14. Kumlin, M., Hamberg, M., Granström, E., Björck, T., Dahlén, B., Matsuda, H., Zetterström, O., and Dahlén, S.-E., 1990, 15(S)-hydroxyeicosatetraenoic acid is the major arachidonic acid metabolite in human bronchi: Association with airway epithelium, Arch. Biochem. Biophys., 282: 254.PubMedCrossRefGoogle Scholar
  15. Lee, T.H., Crea, A.E.G., Gant, V., Spur, B.W., Marron, B.E., Nicolaou, K.C., Reardon, E., Brezinski, M., and Serhan, C.N., 1990, Identification of Lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluid obtained from patients with selected pulmonary diseases, Am. Rev. Respir. Pis., 141: 1453.Google Scholar
  16. Lee, T.H., Horton, C.E., Kyan-Aung, U., Haskard, D., Crea, A.E.G., and Spur, B.W., 1989, Lipoxin A4 and B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-phenylalanine, Clin. Sci., 77: 195.PubMedGoogle Scholar
  17. Lindbom, L., Lundberg, C., Prieto, J., Raud, J., Nortamo, P., Gahmberg, C.G., and Patarroyo, M., 1990, Rabbit leukocyte adhesion molecules CD11/CD18 and their participation in acute and delayed inflammatory responses and leukocyte distribution in vivo, Clin. Immunol. Immunopathol. 57: 105.PubMedCrossRefGoogle Scholar
  18. Nicolaou, K.C., Veale, C.A., Webber, S.E., Katerinopoulus, K., 1985, Stereocontrolled total synthesis of Lipoxins A, J. Am. Chem. Soc, 107: 7515.CrossRefGoogle Scholar
  19. Ramstedt, U., Serhan, C.N., Nicolaou, K.C., Webber, S.E., Wigzell, H., and Samuelsson, B., 1987, Lipoxin A-induced inhibition of natural killer cells: Studies on stereospecificity and mode of action, J. Immunol., 138: 266.PubMedGoogle Scholar
  20. Raud J., 1989, Intravital microscopic studies on acute mast cell-dependent inflammation, Acta Physiol. Scand., 135(Suppl. 578): 1.CrossRefGoogle Scholar
  21. Serhan, C.N., Hamberg, M., and Samuelsson, B., 1984, Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes, Proc. Natl. Acad. Sci. USA., 81: 5335.PubMedCrossRefGoogle Scholar
  22. Williams, T.J., 1983, Interactions between prostaglandins, leukotrienes and other mediators of inflammation, Br. Med. Bull., 39: 239.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Johan Raud
    • 1
  • Ulla Palmertz
    • 1
  • Sven-Erik Dahlén
    • 1
  • Per Hedqvist
    • 1
  1. 1.Department of Physiology I and Institute of Environmental MedicineKarolinska InstitutetStockholmSweden

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