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Role of Eicosanoids and the Cytokine Network in Transmembrane Signaling in Vascular Cells

  • Chapter
Cell-Cell Interactions in the Release of Inflammatory Mediators

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 314))

Abstract

The concept that atherosclerosis is an inflammatory response to injury is based on observations that cells of monocytic origin, including macrophages and T-cells populate the developing atherosclerotic lesion. This is in addition to the well-characterized smooth muscle cell infiltrate1. Since endothelial cell activation or injury is a prerequisite for monocyte adhesion and diapedesis, the histologic evidence described above support the hypothesis that endothelial cell injury is an important initial event in the development of the inflammatory lesion. Activation or injury may thus initiate a series of process that lead to intimai hyperplasia and choiesteryl ester deposition within the macrophage and smooth muscle cell.

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Authors and Affiliations

  1. Departments of Medicine, Cornell University Medical College, New York, NY, USA

    Kenneth B. Pomerantz

  2. Pathology, and Biochemistry and the National Institutes of Health Specialized Center of Research in Thrombosis, Cornell University Medical College, New York, NY, USA

    David P. Hajjar

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  1. Kenneth B. Pomerantz
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  1. New York Medical College, Valhalla, New York, USA

    Patrick Y.-K. Wong

  2. Harvard Medical School, Boston, Massachusetts, USA

    Charles N. Serhan

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© 1991 Plenum Press, New York

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Pomerantz, K.B., Hajjar, D.P. (1991). Role of Eicosanoids and the Cytokine Network in Transmembrane Signaling in Vascular Cells. In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_10

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  • DOI: https://doi.org/10.1007/978-1-4684-6024-7_10

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