Leukocyte Adhesion: Molecular Basis and Relevance in Inflammation
Leukocytes interact with one another, with other cell types such as vascular endothelial cells, and with extracellular matrices to traffic to extravascular tissues, and to generate immune and inflammatory responses. Although some of these interactions are mediated by soluble molecules such as cytokines, others require firm leukocyte-cell or leukocyte-matrix stickiness, a process refered to as adhesion. This adhesiveness is transient and usually subsequent to cell activation. It has a molecular basis and a profound biological relevance in host defense and tissue injury. The present article will summarize our studies on the biology and molecular basis of leukocyte adhesion, and its central role in leukocyte functions and inflammatory responses. Comprehensive reviews have been recently published by us1–4 and by other scientists5–7.
KeywordsBacterial Meningitis Phorbol Ester Leukocyte Adhesion Neural Cell Adhesion Molecule Cell Surface Glycoprotein
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