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Leukocyte Adhesion: Molecular Basis and Relevance in Inflammation

  • Chapter
Cell-Cell Interactions in the Release of Inflammatory Mediators

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 314))

Abstract

Leukocytes interact with one another, with other cell types such as vascular endothelial cells, and with extracellular matrices to traffic to extravascular tissues, and to generate immune and inflammatory responses. Although some of these interactions are mediated by soluble molecules such as cytokines, others require firm leukocyte-cell or leukocyte-matrix stickiness, a process refered to as adhesion. This adhesiveness is transient and usually subsequent to cell activation. It has a molecular basis and a profound biological relevance in host defense and tissue injury. The present article will summarize our studies on the biology and molecular basis of leukocyte adhesion, and its central role in leukocyte functions and inflammatory responses. Comprehensive reviews have been recently published by us1–4 and by other scientists5–7.

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Author information

Authors and Affiliations

  1. Depts. of Immunology and Physiology, Karolinska Institutet, Stockholm, Sweden

    Manuel Patarroyo, Lennart Lindbom & Claes Lundberg

  2. Inflammation Res., Pharmacia, Uppsala, Sweden

    Manuel Patarroyo, Lennart Lindbom & Claes Lundberg

Authors
  1. Manuel Patarroyo
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  2. Lennart Lindbom
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  3. Claes Lundberg
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Editor information

Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Patrick Y.-K. Wong

  2. Harvard Medical School, Boston, Massachusetts, USA

    Charles N. Serhan

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© 1991 Plenum Press, New York

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Patarroyo, M., Lindbom, L., Lundberg, C. (1991). Leukocyte Adhesion: Molecular Basis and Relevance in Inflammation. In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_1

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  • DOI: https://doi.org/10.1007/978-1-4684-6024-7_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6026-1

  • Online ISBN: 978-1-4684-6024-7

  • eBook Packages: Springer Book Archive

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