Abstract
Epithelial cell lines derived from rat thyroid have been employed to analyze the effects of ras-induced transformation on the signal pathways regulating growth and differentiation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
F.S. Ambesi-Impiombato, and H. Perrild eds FRTL5 today. Elsevier Science Publishers, Amsterdam, (1989).
F. S. Ambesi-Impiombato, R. Picone, and D. Tramontano, Influence of hormones and serum on growth and differentiation of the thyroid cell strain FRTL, Cold Spring Harbor Symp. Quant. Biol. 9:483–492 (1982).
W.A. Valente, P. Vitti, L.D. Kohn, M.L. Brandi, C.M. Rotella, R. Toccafondi, D. Tramontano, S.M. Aloj and F.S. Ambesi-Impiombato, The relationship of growth and adenylate cyclase activity in cultured thyroid cells: separate bioeffects of thyrotropin, Endocrinology 112:71–79 (1983).
A. Fusco, A. Pinto, F.S. Ambesi-Impiombato, G. Vecchio, and N. Tsuchida, Transformation of rat thyroid epithelial cells by kirsten murine sarcoma virus, Int. J. Cancer 28:655–662 (1981).
A. Fusco, A. Pinto, D. Tramontano, G. Tajana, G. Vecchio, and N. Tsuchida, Block in the expression of differentiation markers of rat thyroid epithelial cells by transformation with kirsten murine sarcoma virus, Cancer Res., 42:618–626 (1982).
G. Colletta, A. Pinto, P.P. Di Fiore, A. Fusco, M. Ferrentino, V.E. Avvedimento, N. Tsuchida, and G. Vecchio, Dissociation between transformed and differentiated phenotype in rat thyroid epithelial cells after transformation with a temperature-sensitive mutant of the kirsten murine sarcoma virus, Mol. Cell. Biol. 3:2099–2109 (1983).
G. Colletta, D. Corda, G. Schettini, A.M. Cirafici, L.D. Kohn, and E. Consiglio, Adenylate cyclase activity v-ras-k transformed rat epithelial thyroid cells FEBS Lett. 228:37–41 (1988).
S. Valitutti, P. Cucchi, G. Colletta, C. Di Filippo, and D. Corda, Transformation by the K-ras oncogene correlates with increases in phospholipase A2 activity, glycerophosphoinositol production and phosphoinositide synthesis in thyroid cells, Cell. Signal., in press (1991).
M. Di Girolamo, D. D’Arcangelo, P. Gierschik, and D. Corda, Characterization of trimeric G proteins in normal and k-ras transformed cells. Cell Biol. Int. Rep., 14S:45 (1990).
M. Di Girolamo, D. D’Arcangelo, P. Gierschik, and D. Corda, Increased ADP- ribosylation of trimeric G proteins in k-ras transformed cells, (submitted)
D. Bar-Sagi, and J.R. Feramisco, Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins Science 233:1061–1068 (1986).
D. Corda, C. Marcocci, L.D. Kohn, J. Axelrod, and A. Luini, Association of the changes in cytosolic Ca2+ and iodide efflux induced by thyrotropin and by the stimulation of α1-adrenergic receptors in cultured rat thyroid cell, J. Biol. Chem. 260:9230–9236 (1985).
D. Corda, and L.D. Kohn, Role of pertussis toxin sensitive G proteins in the alpha-1 adrenergic receptor but not in the thyrotropin receptor mediated activation of membrane phospholipases and iodide fluxes in FRTL-5 thyroid cells, Biochem. Biophys. Res. Commun. 141:1000–1006 (1986).
C. Bizzarri, M. Di Girolamo, M.C. D’Orazio, D. Corda, Evidence that a guanine nucleotide-binding protein linked to a muscarinic receptor inhibits directly phospholipase C., Proc. Natl. Acad. Sci. USA 87:4889–4893 (1990).
R.M. Burch, A. Luini, and J. Axelrod, Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to α1-adrenergic stimulation in FRTL5 thyroid cells, Proc. Natl. Acad. Sci. USA 83:7201–7205 (1986).
D. Corda, L. Iacovelli, and M. Di Girolamo, Coupling of the α1-adrenergic and thyrotropin receptors to second messenger systems in thyroid cells. Role of G-proteins. In: Maggi M, Johnston CA (eds) Horizons in Endocrinology. Raven Press, New York, 169–180 (1988).
D. Corda, C. Bizzarri, M. Di Girolamo, S. Valitutti, and A. Luini, G protein-linked receptors in the thyroid, Adv. Exp. Med. Biol. 2 61:245–269 (1989).
D. Corda, R.D. Sekura, and L.D. Kohn, Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin, Eur. J. Biochem. 166:475–481 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Corda, D., Valitutti, S., Iacovelli, L., Di Girolamo, M. (1991). Increases in Phospholipase A2 Activity and in the ADP Ribosylation of G Proteins in K-ras-Transformed Thyroid Cells. In: Spandidos, D.A. (eds) The Superfamily of ras-Related Genes. NATO ASI Series, vol 220. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6018-6_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-6018-6_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-6020-9
Online ISBN: 978-1-4684-6018-6
eBook Packages: Springer Book Archive