Abstract
Both in unicellular and multicellular organisms, a large number of structurally related small GTP-binding proteins, collectively known as ras superfamily of proteins, has been identified within the past few years. These proteins are similar in size and they share highly conserved sequence motifs which, in the case of H-ras p21, have been demonstrated to be contact regions for the bound nucleotide (see 1,2 for review). It is thought, and in very few cases it is known, that the diverse members of this superfamily of proteins are regulators of basic cellular processes, including the transmission of proliferation signals, the vectorial transport and the fusion of vesicles, the proper functioning of the cytoskeleton and cell differentiation (see 1–3 for review).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bourne, H.R., Sanders, D.A., and McCormick, F. (1990) Nature, 348, 125–132.
Bourne, H.R., Sanders, D.A., and McCormick, F. (1991) Nature, 349, 117–127.
Hall, A. (1990) Science, 249, 635–640.
Gallwitz, D., Haubruck, H., Molenaar, C., Prange, R., Puzicha, M., Schmitt, H.D., Vorgias, C. and Wagner, P. (1989) In Bosch, L., Kraal, B., and Parmeggiani, A. (eds.) The Guanine-nucleotide Binding Proteins. Plenum Press, New York; NATO ASI Series A: Life Sciences, Vol 165, pp. 257–264.
Birchmeier, C., Broek, D., and Wigier, M. (1985) Cell, 43, 615–621.
Beckner, S.K., Hattori, S., and Shih, T.Y. (1985) Nature, 317, 71–72.
Downward, J., Graves, J.D., Warne, P.H., Rayter, S., and Cantrell, D.A. (1990) Nature, 346, 719–723.
Segev, N., Mulholland, J., and Botstein, D. (1988) Cell, 52, 915–924.
Schmitt, H.D., Puzicha, M., and Gallwitz, D. (1988) Cell, 53, 635–647.
Baker, D., Wuestehube, L., Scheckman, R., Botstein, D., and Segev, N. (1990) Proc. Natl. Acad. Sci. USA, 87, 355–359.
Becker, J., Tan, T.J., Trepte, H.-H., and Gallwitz, D. (1991) EMBO J., 10, 785–792.
Salminen, A., and Novick, P.J. (1987) Cell, 49, 527–538.
Walworth, N.C., Goud, B., Kabcenell, A.K., and Novick, P.J. (1989) EMBO J., 8, 1685–1693.
Nakano, A., and Muramatsu, M. (1989) J.Cell Biol., 109, 2677–2691.
Stearns, T., Willingham, M.C., Botstein, D., and Kahn, R.A. (1990) Proc. Natl. Acad. Sci. USA, 87, 1238–1242.
Chavrier, P., Parton, R.G., Hauri, H.P., Simons, K., and Zerial, M. (1990) Cell 62, 317–329.
Goud, B., Zahraoui, A., Tavitian, A., and Saraste, J. (1990) Nature 345, 553–556.
Melancon, P., Glick, B.S., Malhotra, V., Weidman, P.J., Serafini, T., Gleason, M.L., Orci, L., and Rothmann, J.E. (1987) Cell, 51, 1053–1062.
Goda, Y., and Pfeffer, S.R. (1988) Cell, 55, 309–320.
Beckers, C.J.M., and Balch, W.E. (1989) J. Cell Biol. 108, 1245–1256.
Haubruck, H., Prange, R., Vorgias, C., and Gallwitz D. (1989) EMBO J., 8, 1427–1432.
Miyake, S., and Yamamoto, M. (1990) EMBO J., 9, 1417–1422.
Haubruck, H., Engelke, U., Mertins, P., and Gallwitz, D. (1990) EMBO J., 9, 1957–1962.
Hengst, L., Lehmeier, T., and Gallwitz, D. (1990) EMBO J. 9, 1949–1955.
Dascher, C., Ossig, R., Gallwitz, D., and Schmitt, H.D. (1991) Mol. Cell. Biol. 11, 872–885.
Bowser, R., and Novick, P. (1991) J. Cell. Biol., 112, 1117–1131.
McCormick, F. (1989) Cell, 56, 5–8.
DeFeo-Jones, D., Tatchell, K., Robinson, L.C., Sigal, I.S., Vass, W.C., Lowy, D.R., and Scolnick, E.M. (1985) Science, 228, 179–184
Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., and Wigier, M. (1985) Cell, 40, 19–26.
Wagner, P., Molenaar, C.M.T., Rauh, A.J.G., Brökel, R., Schmitt, H.D., and Gallwitz, D. (1987) EMBO J., 6, 2373–2379.
Tanaka, K., Lin, B.K., Wood, D.R., and Tamanoi, F. (1991) Proc. Natl. Acad. Sci. USA, 88, 468–472.
Ballester, R., Michaeli, T., Ferguson, K., Xu, H.-P., McCormick, F., and Wigier, M. (1989) Cell, 59, 681–686.
Tanaka, K., Matsumoto, K., and Toh, E.-A. (1989) Mol. Cell. Biol., 9, 757–768.
Zhang, K., DeClue, J.E., Vass, W.C., Papageorge, A.G., McCormick, F., and Lowy, D.R. (1990) Nature 346, 754–756.
Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J., and Wigier, M. (1984) Cell, 36, 607–612.
Bender, A., and Pringle, J.R. (1989) Proc. Natl. Acad. Sci. USA 86, 9976–9980.
Schmitt, H.D., Wagner, P., Pfaff, E., and Gallwitz, D. (1986) Cell, 47, 401–412.
Madaule, P., Axel, R., and Myers, A.M. (1987) Proc. Natl. Acad. Sci. USA, 84, 779–783.
Johnson, D.I., and Pringle, J.R. (1990) J. Cell Biol. 11, 143–152.
Capon, D.J., Chen, E.Y., Levinson, A.D., Seeburg, P., and Goeddel, D.V. (1983) Nature 302, 33–37.
Fukui, Y., and Kaziro, Y. (1985) EMBO J., 4, 687–691.
Zahraoui, A., Touchot, N., Chardin, P., and Tavitian, A. (1989) J. Biol. Chem., 264, 12394–12401.
Chavrier, P., Vingron, M., Sander, C., Simons, K., and Zerial, M., (1990) Mol. Cell. Biol. 10, 6579–6585.
Gallwitz, D., Donath, C., and Sander, C. (1983) Nature, 306, 704–707.
Haubruck, H., Disela, C., Wagner, P., and Gallwitz, D. (1987) EMBO J., 6, 4049–4053.
Saxe, S.A., and Kimme1, A.R. (1990) Mol. Cell. Biol. 10, 2367–2378.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Gallwitz, D. et al. (1991). The YPT-Branch of the ras Superfamily of GTP-Binding Proteins in Yeast: Functional Importance of the Putative Effector Region. In: Spandidos, D.A. (eds) The Superfamily of ras-Related Genes. NATO ASI Series, vol 220. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6018-6_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-6018-6_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-6020-9
Online ISBN: 978-1-4684-6018-6
eBook Packages: Springer Book Archive