Abstract
Muscle contraction is the development of force or of motion by interaction of two complex proteins, actin and myosin. Their interaction results in relative translation of the thick (myosin) and thin (actin) filaments. The interaction is a chemical association between the head of the myosin molecule and the actin molecule, and force or motion results from a bending of the head where it joins the backbone of the myosin molecule. The chemical interaction itself is permitted as a consequence of a cascade of chemical events resulting from binding of Ca2+ to one of a heterotrimeric troponin complex. That interaction causes a change in a tropomyosin molecule, which releases actin sites for reaction with myosin.
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© 1991 Plenum Press, New York
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Fozzard, H.A. (1991). Excitation-Contraction Coupling in the Heart. In: Cox, R.H. (eds) Cellular and Molecular Mechanisms in Hypertension. Advances in Experimental Medicine and Biology, vol 308. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6015-5_11
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DOI: https://doi.org/10.1007/978-1-4684-6015-5_11
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