Abstract
The multigene family human pepsinogen A (PGA) consists of several isozymogens.1,2 DNA sequences for PGA-3, 4, and 5 have previously been reported.3 The substitutions between the various allozymogens (PGA residue numbering according to Evers et al.) are
-
(1)
PGA-3: Glu43, Val77,Gln207, Ala250, Leu338;
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(2)
PGA-4: Glu43, Leu77,Lys207,Thr250,Val338 and
-
(3)
PGA-5: Lys43, Leu77, Gln207, Ala250, Leu338.
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© 1991 Plenum Press, New York
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Bank, R.A., Russell, R.B., Pals, G., James, M.N.G. (1991). Consequences of Intramolecular Ionic Interactions for the Activation Rate of Human Pepsinogens A and C as Revealed by Molecular Modelling. In: Dunn, B.M. (eds) Structure and Function of the Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 306. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6012-4_11
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DOI: https://doi.org/10.1007/978-1-4684-6012-4_11
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