Abstract
Human pepsinogen, the inactive precursor of pepsin, comprises two biochemically and immunologically distinct groups of isozymogens; namely PGA and PGC. PGA has been localized to 11ql3 and PGC to 6p21.1→pter.1–4 Previous studies demonstrated that a region of the human pepsinogen C gene contained a restriction fragment length polymorphism by Southern blot analysis of genomic DNA with a PGC cDNA clone. This RFLP involved a 100 bp insertion or deletion of intron sequence located between exons 7 and 8. Analysis of families segregating for this polymorphism indicated that there is a single human PGC gene located on the short arm of chromosome 6.
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© 1991 Plenum Press, New York
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Taggart, R.T., Azuma, T., Wu, S., Bell, G.I., Bowcock, A.M. (1991). A Highly Informative Polymorphism of the Pepsinogen C Gene Detected by Polymerase Chain Reaction. In: Dunn, B.M. (eds) Structure and Function of the Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 306. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6012-4_10
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DOI: https://doi.org/10.1007/978-1-4684-6012-4_10
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