Abstract
The neutrophils normally circulate passively in the blood and are recruited at sites of infection or inflammation by chemotactic agonists that turn them on and direct their migration into the tissues. The adhesion to the venular endothelium, the passage through the vessel wall and the directed movement in the interstitium are complex events involving motile and secretory functions. Three main responses of neutrophils, the shape change, the exocytosis of storage components, and the respiratory burst can be analyzed in real time in vitro, and we shall describe here how these responses are induced by NAP-1 and other chemotactic agonists.
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© 1991 Plenum Press, New York
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Baggiolini, M., Dewald, B., Walz, A. (1991). Activation of Human Neutrophils by NAP-1 and Other Chemotactic Agonists. In: Westwick, J., Lindley, I.J.D., Kunkel, S.L. (eds) Chemotactic Cytokines. Advances in Experimental Medicine and Biology, vol 305. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6009-4_2
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