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NAP-1/IL-8 in Rheumatoid Arthritis

  • Chapter
Chemotactic Cytokines

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 305))

Abstract

Neutrophil activating peptide 1, or interleukin-8 (NAP-1, IL-8), was isolated almost simultaneously by several groups as a neutrophil chemotactic or activating peptide from supernatants of endotoxin stimulated monocytes (1–5). The major form with 72 amino acids, and an approximate molecular weight of 8.4 kD, has since been shown to have activities on a variety of different cell types. It is chemotactic for neutrophils (PMN) and lymphocytes both in vitro and in vivo (6,2,4,7), and has been shown to stimulate PMN in vitro to degranulate and to exhibit respiratory burst (8,9), and thus has the basic attributes of an inflammatory mediator. Further actions which could be of great importance in inflammatory processes are chemotactic attraction of basophils, the triggering of IL-3 primed basophils to release leukotrienes and histamine (10), spasmogenic activity on airway smooth muscle (11), and effects on PMN adherence to endothelial cells (12).

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Authors and Affiliations

  1. Sandoz Forschungsinstitut, Brunner Strasse 59, A-1235, Vienna, Austria

    Ivan J. D. Lindley, Miroslav Ceska & Peter Peichl

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  1. Ivan J. D. Lindley
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  2. Miroslav Ceska
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  3. Peter Peichl
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Editor information

Editors and Affiliations

  1. The University of Bath, Avon, UK

    J. Westwick

  2. Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  3. University of Michigan, Ann Arbor, Michigan, USA

    S. L. Kunkel

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© 1991 Plenum Press, New York

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Lindley, I.J.D., Ceska, M., Peichl, P. (1991). NAP-1/IL-8 in Rheumatoid Arthritis. In: Westwick, J., Lindley, I.J.D., Kunkel, S.L. (eds) Chemotactic Cytokines. Advances in Experimental Medicine and Biology, vol 305. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6009-4_17

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  • DOI: https://doi.org/10.1007/978-1-4684-6009-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6011-7

  • Online ISBN: 978-1-4684-6009-4

  • eBook Packages: Springer Book Archive

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